The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells
Abstract
Vitamin D is a potent immune system regulator. The active form of vitamin D (1,25(OH)2 D 3) suppresses the development of animal models of human autoimmune diseases. 1,25(OH)2 D 3 decreased the proliferation of all T helper (h) cells and decreased the production of IFN‐γ, IL‐2, and IL‐5. In Th2 cells 1,25(OH)2 D 3 increased the production of IL‐4. Quiescent CD4+ T cells express vitamin D receptors but only at a low level, which increased five‐fold following activation. 1,25(OH)2 D 3 treatment of Th0 cells, but not Th1 or Th2 cells, induced the expression of the transcription factor GATA‐3. Microarray technology identified over 102 targets of 1,25(OH)2 D 3 in CD4+ T cells. Of the 102 genes, 57 genes were down‐regulated and 45 were up‐regulated by 1,25(OH)2 D 3 treatment of the CD4+ T cells. Two of the identified genes are regulators of NFkB. Other genes of interest included the IL‐2Rβ gene and IgE binding factor. Th2 and Th0 cells produced more IgE binding factor after treatment with 1,25(OH)2 D 3 while Th1 cell IgE binding factor expression was unaffected by 1,25(OH)2 D 3 addition. It is unclear why some of the genes identified are expressed in CD4+ T cells and furthermore why 1,25(OH)2 D 3 regulates the expression of these genes. Clearly CD4+ T cells can be direct targets of vitamin D. The targets of vitamin D in CD4+ T cells depend on the state of activation and differentiation status of the cells. J. Cell. Biochem. 89: 922–932, 2003. © 2003 Wiley‐Liss, Inc.
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Heid, C. A., Stevens, J., Livak, K. J., & Williams, P. M. (1996) · Genome Research · doi:10.1101/gr.6.10.986 · Cited by 6,174
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
Bonecchi, R., Bianchi, G., Bordignon, P. P., D'Ambrosio, D., Lang, R., Borsatti, A., Sozzani, S., Allavena, P., Gray, P. A., Mantovani, A., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.1.129 · Cited by 2,014
Barrat, F. J., Cua, D. J., Boonstra, A., Richards, D. F., Crain, C., Savelkoul, H. F., de Waal-Malefyt, R., Coffman, R. L., Hawrylowicz, C. M., & O'Garra, A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011629 · Cited by 1,161
Boonstra, A., Barrat, F. J., Crain, C., Heath, V. L., Savelkoul, H. F. J., & O’Garra, A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.4974 · Cited by 1,123
Cantorna, M. T., Hayes, C. E., & DeLuca, H. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7861 · Cited by 718
Self-citationExpression of 1,25-Dihydroxyvitamin D3 Receptor in the Immune System
Veldman, C. M., Cantorna, M. T., & DeLuca, H. F. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1605 · Cited by 710
Self-citationNavigating gene expression using microarrays — a technology review
Schulze, A., & Downward, J. (2001) · Nature Cell Biology · doi:10.1038/35087138 · Cited by 535
Cantorna, M. T., Munsick, C., Bemiss, C., & Mahon, B. D. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.11.2648 · Cited by 494
Self-citationGregori, S., Giarratana, N., Smiroldo, S., Uskokovic, M., & Adorini, L. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1367 · Cited by 483
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Pludowski, P., Holick, M. F., Pilz, S., Wagner, C. L., Hollis, B. W., Grant, W. B., Shoenfeld, Y., Lerchbaum, E., Llewellyn, D. J., Kienreich, K., et al. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.02.004 · Cited by 836
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Lin, Y.-D., Arora, J., Diehl, K., Bora, S. A., & Cantorna, M. T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00001 · Cited by 601
Self-citationImmunomodulatory effects of Vitamin D in multiple sclerosis
Correale, J., Ysrraelit, M. C., & Gaitan, M. I. (2009) · Brain · doi:10.1093/brain/awp033 · Cited by 538
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Metadata
- Authors
- Mahon, B. D., Wittke, A., Weaver, V., & Cantorna, M. T.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2003-07-15
- Volume
- 89
- Issue
- 5
- Pages
- 922-932
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2106044877
- Cited by
- 466
- References
- 25
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- closed
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