The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Ets proteins in biological control and cancer
Open accessAbstract
The Ets family consists of a large number of evolutionarily conserved transcription factors, many of which have been implicated in tumor progression. Extensive studies on this family of proteins have focused so far mainly on the biochemical properties and cellular functions of individual factors. Since most of the Ets factors can bind to the core consensus DNA sequence GGAA/T in vitro, it has been a challenge to differentiate redundant from specific functions of various Ets proteins in vivo. Recent findings, however, suggest that such apparent redundancy may in fact be a central component of a network of differentially regulated specific Ets factors, resulting in distinct biological and pathological consequences. The programmed “Ets conversion” appears to play a critical role during tumor progression, especially in control of cellular changes during epithelial–mesenchymal transition and metastasis. Coordination of multiple Ets gene functions also mediates interactions between tumor and stromal cells. As such, these new insights may provide a novel view of the Ets gene family as well as a focal point for studying the complex biological control involved in tumor progression. © 2004 Wiley‐Liss, Inc.
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Cites
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Molecular biology of the Ets family of transcription factors
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The organizing principle: microenvironmental influences in the normal and malignant breast
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Clinical, Cellular, and Molecular Aspects of Cancer Invasion
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Cited by
Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
Tomlins, S. A., Rhodes, D. R., Perner, S., Dhanasekaran, S. M., Mehra, R., Sun, X.-W., Varambally, S., Cao, X., Tchinda, J., Kuefer, R., et al. (2005) · Science · doi:10.1126/science.1117679 · Cited by 3,846
Yu, J., Yu, J., Mani, R.-S., Cao, Q., Brenner, C. J., Cao, X., Wang, X., Wu, L., Li, J., Hu, M., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.03.018 · Cited by 850
Genomic and biochemical insights into the specificity of ETS transcription factors
Hollenhorst, P. C., McIntosh, L. P., & Graves, B. J. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.79.081507.103945 · Cited by 490
ETS transcription factors and their emerging roles in human cancer
Seth, A., & Watson, D. K. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.08.013 · Cited by 469
Self-citationYoshimoto, M., Joshua, A. M., Cunha, I. W., Coudry, R. A., Fonseca, F. P., Ludkovski, O., Zielenska, M., Soares, F. A., & Squire, J. A. (2008) · Modern Pathology · doi:10.1038/modpathol.2008.96 · Cited by 279
Metadata
- Authors
- Hsu, T., Trojanowska, M., & Watson, D. K.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2004-02-23
- Volume
- 91
- Issue
- 5
- Pages
- 896-903
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2103555733
- Cited by
- 287
- References
- 33
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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