FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations

Hébert, Jean M.; Rosenquist, Thomas; Götz, Jürgen; Martin, Gail R.

doi:10.1016/0092-8674(94)90276-3

Cited by 604Hair Growth and DisordersFibroblast Growth Factor Researchdental development and anomalies

FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations

Hébert, Jean M., Rosenquist, Thomas, Götz, Jürgen, Martin, Gail R.·1994·Cell

DOI 10.1016/0092-8674(94)90276-3

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Abstract

Fibroblast growth factor 5 (FGF5) is a secreted signaling protein. Mice homozygous for a predicted null allele of the Fgf5 gene, fgf5neo, produced by gene targeting in embryonic stem cells, have abnormally long hair. This phenotype appears identical to that of mice homozygous for the spontaneous mutation angora (go). The fgf5neo and go mutations fail to complement one another, and exon 1 of Fgf5 is deleted in DNA from go homozygotes, demonstrating that go is a mutant allele of Fgf5. Expression of Fgf5 is detected in hair follicles from wild-type mice and is localized to the outer root sheath during the anagen VI phase of the hair growth cycle. These findings provide evidence that FGF5 functions as an inhibitor of hair elongation, thus identifying a molecule whose normal function is apparently to regulate one step in the progression of the follicle through the hair growth cycle.

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Authors: Hébert, J. M., Rosenquist, T., Götz, J., & Martin, G. R.
Affiliations: University of California, San Francisco (US)
ORCID: Hébert, Jean M.
Rosenquist, Thomas
Götz, Jürgen
Venue: Cell
Publisher: Elsevier BV
Published: 1994-09
Volume: 78
Issue: 6
Pages: 1017-1025
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(94)90276-3
OpenAlex: W2056016311
Cited by: 589
References: 67
Citations by year: 2026: 12 · 2025: 14 · 2024: 9 · 2023: 21 · 2022: 24 · 2021: 15 · 2020: 23 · 2019: 15 · 2018: 10 · 2017: 21 · 2016: 22 · 2015: 12 · 2014: 18 · 2013: 16 · 2012: 20
FWCI: 35.68
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: Lucille P. Markey Charitable Trust (8814)
National Institutes of Health (CA 09043, PO1 HL 43821, ROl HD22731)
Topics: Health Sciences › Medicine › Urology › Hair Growth and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
Keywords: FGF5, hair cycle, anagen, outer root sheath, hair follicle, gene targeting, spontaneous mutation, complementation
MeSH terms: Alleles, Animals, Base Sequence, Fibroblast Growth Factors, Genetic Complementation Test, Hair, Homozygote, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Mutant Strains, Molecular Sequence Data, Phenotype, RNA, Messenger, Tissue Distribution, Transforming Growth Factor alpha, In Situ Hybridization, Mice, Knockout, Mice, Fibroblast Growth Factor 5

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FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations

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