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Expression and function of periostin‐isoforms in bone
Abstract
Periostin was originally identified in MC3T3‐E1 osteoblast‐like cells. We have identified an isoform of periostin referred to as periostin‐like‐factor (PLF). It is homologous to other proteins such as fasciclin I (fas I), MPB70, βIG‐H3, and Algal‐CAMs. All of these proteins are implicated in regulating cell adhesion. PLF and the other isoforms of periostin differ in their C‐terminal sequences. PLF and periostin differ in two specific regions, between 673 and 699 amino acids (aa) and 785–812 aa. Periostin isoforms are expressed in vivo and in vitro during the stages of osteoblast differentiation and maturation. Their mRNAs are present in pre‐osteoblast cells as detected by in situ hybridization, and the proteins are between 86 and 93 kD in size as determined by Western blot analysis. Antisense oligonucleotides and antibodies directed against the isoforms of periostin were used to block the activity of these proteins. In both cases, the levels of osteoblast‐specific‐differentiation markers were markedly reduced suggesting a role for these proteins in osteoblast differentiation. © 2004 Wiley‐Liss, Inc.
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Cited by
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Franz‐Odendaal, T. A., Hall, B. K., & Witten, P. E. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20603 · Cited by 795
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Kühn, B., del Monte, F., Hajjar, R. J., Chang, Y.-S., Lebeche, D., Arab, S., & Keating, M. T. (2007) · Nature Medicine · doi:10.1038/nm1619 · Cited by 659
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Acott, T. S., & Kelley, M. J. (2008) · Experimental Eye Research · doi:10.1016/j.exer.2008.01.013 · Cited by 503
Butcher, J. T., Norris, R. A., Hoffman, S., Mjaatvedt, C. H., & Markwald, R. R. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2006.09.048 · Cited by 176
Metadata
- Authors
- Litvin, J., Selim, A., Montgomery, M. O., Lehmann, K., Rico, M. C., Devlin, H., Bednarik, D. P., & Safadi, F. F.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2004-06-14
- Volume
- 92
- Issue
- 5
- Pages
- 1044-1061
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W1985276061
- Cited by
- 178
- References
- 0
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Litvin, J., Selim, A., Montgomery, M. O., Lehmann, K., Rico, M. C., Devlin, H., Bednarik, D. P., & Safadi, F. F. (2004). Expression and function of periostin‐isoforms in bone. Journal of Cellular Biochemistry. https://doi.org/10.1002/jcb.20115
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