The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Mechanisms of metastasis: Epithelial‐to‐mesenchymal transition and contribution of tumor microenvironment
Abstract
Every year about 500,000 people in the United States die as a result of cancer. Among them, 90% exhibit systemic disease with metastasis. Considering this high rate of incidence and mortality, it is critical to understand the mechanisms behind metastasis and identify new targets for therapy. In recent years, two broad mechanisms for metastasis have received significant attention: epithelial‐to‐mesenchymal transition (EMT) and tumor microenvironment interactions. EMT is believed to be a major mechanism by which cancer cells become migratory and invasive. Various cancer cells—both in vivo and in vitro—demonstrate features of epithelial‐to‐mesenchymal‐like transition. In addition, many steps of metastasis are influenced by host contributions from the tumor microenvironment, which help determine the course and severity of metastasis. Here we evaluate the diverse mechanisms of EMT and tumor microenvironment interactions in the progression of cancer, and construct a rational argument for targeting these pathways to control metastasis. J. Cell. Biochem. 101: 816–829, 2007. © 2007 Wiley‐Liss, Inc.
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Self-citationFunctional interaction of β-catenin with the transcription factor LEF-1
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Background
Cited by
The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196
Self-citationFate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis
Humphreys, B. D., Lin, S.-L., Kobayashi, A., Hudson, T. E., Nowlin, B. T., Bonventre, J. V., Valerius, M. T., McMahon, A. P., & Duffield, J. S. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090517 · Cited by 1,442
Cancer as an overhealing wound: an old hypothesis revisited
Schäfer, M., & Werner, S. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2455 · Cited by 956
Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth
Shiga, K., Hara, M., Nagasaki, T., Sato, T., Takahashi, H., & Takeyama, H. (2015) · Cancers · doi:10.3390/cancers7040902 · Cited by 774
The role of endothelial-to-mesenchymal transition in cancer progression
Potenta, S., Zeisberg, E., & Kalluri, R. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604662 · Cited by 554
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Metadata
- Authors
- Tse, J. C., & Kalluri, R.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2007-01-22
- Volume
- 101
- Issue
- 4
- Pages
- 816-829
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2172083228
- Cited by
- 370
- References
- 8
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- closed
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