The snail superfamily of zinc-finger transcription factors

The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

Cano, A., Pérez‐Moreno, M., Rodrigo, I., Locascio, A., Blanco, M. J., Barrio, M. G. D., Portillo, F., & Nieto, M. A. (2000) · Nature Cell Biology · doi:10.1038/35000025 · Cited by 3,672 · see citing works

The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

Batlle, E., Sancho, E., Francı́, C., Dominguez-Sola, D., Monfar, M., Baulida, J., & de Herreros, A. G. (2000) · Nature Cell Biology · doi:10.1038/35000034 · Cited by 2,671 · see citing works

Principles of Tissue Engineering

(2014) · Elsevier eBooks · doi:10.1016/c2011-0-07193-4 · Cited by 1,909 · see citing works

An Overview of Epithelio-Mesenchymal Transformation

Hay, E. D. (1995) · Cells Tissues Organs · doi:10.1159/000147748 · Cited by 1,577 · see citing works

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

N�sslein-Volhard, C., Wieschaus, E. F., & Kluding, H. (1984) · Development Genes and Evolution · doi:10.1007/bf00848156 · Cited by 1,550 · see citing works

The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.

Comijn, J., Berx, G., Vermassen, P., Verschueren, K., van Grunsven, L. V., Bruyneel, E., Mareel, M., Huylebroeck, D., & van Roy, F. (2001) · Molecules and Cells · doi:10.1016/s1097-2765(01)00260-x · Cited by 1,464 · see citing works

A causal role for E-cadherin in the transition from adenoma to carcinoma

Perl, A. T., Wilgenbus, P., Dahl, U., Semb, H., & Christofori, G. (1998) · Nature · doi:10.1038/32433 · Cited by 1,419 · see citing works

Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm

Liem, K. F., Tremml, G., Roelink, H., & Jessell, T. M. (1995) · Cell · doi:10.1016/0092-8674(95)90276-7 · Cited by 1,071 · see citing works

Neural Crest and the Origin of Vertebrates: A New Head

Gans, C., & Northcutt, R. G. (1983) · Science · doi:10.1126/science.220.4594.268 · Cited by 1,053 · see citing works

Gene duplications and the origins of vertebrate development

Holland, P. W. H., García‐Fernàndez, J., Williams, N. A., & Sidow, A. (1994) · Development · doi:10.1242/dev.1994.supplement.125 · Cited by 951 · see citing works

Structure of the zebrafish <i>snail1</i> gene and its expression in wild-type, <i>spadetail</i> and <i>no tail</i> mutant embryos

Thisse, C., Thisse, B., Schilling, T. F., & Postlethwait, J. H. (1993) · Development · doi:10.1242/dev.119.4.1203 · Cited by 877 · see citing works

Vertebrate genome evolution and the zebrafish gene map

Postlethwait, J. H., Yan, Y., Gates, M. A., Horne, S., Amores, A., Brownlie, A., Donovan, A., Egan, E. S., Force, A. G., Gong, Z., et al. (1998) · Nature Genetics · doi:10.1038/ng0498-345 · Cited by 829 · see citing works

Control of Cell Behavior During Vertebrate Development by Slug , a Zinc Finger Gene

Nieto, M. A., Sargent, M. G., Wilkinson, D. G., & Cooke, J. (1994) · Science · doi:10.1126/science.7513443 · Cited by 770 · see citing works

Yesterday's polyploids and the mystery of diploidization

Wolfe, K. H. (2001) · Nature Reviews Genetics · doi:10.1038/35072009 · Cited by 767 · see citing works

β-catenin: a key mediator of Wnt signaling

Willert, K., & Nusse, R. (1998) · Current Opinion in Genetics &amp; Development · doi:10.1016/s0959-437x(98)80068-3 · Cited by 753 · see citing works

FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak

Ciruna, B. G., & Rossant, J. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00017-x · Cited by 705 · see citing works

Wnt signalling required for expansion of neural crest and CNS progenitors

Ikeya, M., Lee, S. M. K., Johnson, J. E. B., McMahon, A. P., & Takada, S. (1997) · Nature · doi:10.1038/40146 · Cited by 684 · see citing works

TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis

Oft, M., Heider, K., & Beug, H. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00533-7 · Cited by 624 · see citing works

The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition

Carver, E. A., Jiang, R., Lan, Y., Oram, K. F., & Gridley, T. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.23.8184-8188.2001 · Cited by 624 · see citing works

Correlation of Snail expression with histological grade and lymph node status in breast carcinomas

Blanco, M. J., Moreno‐Bueno, G., Sarrió, D., Locascio, A., Cano, A., Palacios, J., & Nieto, M. A. (2002) · Oncogene · doi:10.1038/sj.onc.1205416 · Cited by 576 · see citing works

twist and snail as positive and negative regulators during Drosophila mesoderm development.Preprint

Leptin, M. (1991) · Genes & Development · doi:10.1101/gad.5.9.1568 · Cited by 571 · see citing works

The Zinc-Finger Protein Slug Causes Desmosome Dissociation, an Initial and Necessary Step for Growth Factor–induced Epithelial–Mesenchymal Transition

Savagner, P., Yamada, K. M., & Thiery, J. P. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.6.1403 · Cited by 520 · see citing works

Control of neural crest cell fate by the Wnt signalling pathway

Dorsky, R. I., Moon, R. T., & Raible, D. W. (1998) · Nature · doi:10.1038/24620 · Cited by 512 · see citing works

Neural crest induction in Xenopus: evidence for a two-signal model

LaBonne, C., & Bronner-Fraser, M. E. (1998) · Development · doi:10.1242/dev.125.13.2403 · Cited by 502 · see citing works

Induction of the prospective neural crest of Xenopus

Mayor, R., Morgan, R., & Sargent, M. G. (1995) · Development · doi:10.1242/dev.121.3.767 · Cited by 471 · see citing works

A New Role for E12/E47 in the Repression ofE-cadherin Expression and Epithelial-Mesenchymal Transitions

Pérez‐Moreno, M., Locascio, A., Rodrigo, I., Dhondt, G., Portillo, F., Nieto, M. A., & Cano, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100827200 · Cited by 440 · see citing works

Ventral and Lateral Regions of the Zebrafish Gastrula, Including the Neural Crest Progenitors, Are Established by abmp2b/swirlPathway of Genes

Nguyen, V., Schmid, B., Trout, J., Connors, S. A., Ekker, M., & Mullins, M. C. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8927 · Cited by 438 · see citing works

DIRECT EVIDENCE FOR A ROLE OF β‐CATENIN/LEF‐1 SIGNALING PATHWAY IN INDUCTION OF EMT

Kim, K., Lu, Z., & Hay, E. D. (2002) · Cell Biology International · doi:10.1006/cbir.2002.0901 · Cited by 428 · see citing works

The Rho GTPase and a Putative RhoGEF Mediate a Signaling Pathway for the Cell Shape Changes in Drosophila Gastrulation

Barrett, K., Leptin, M., & Settleman, J. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80482-1 · Cited by 400 · see citing works

Neural crest emigration from the neural tube depends on regulated cadherin expression

Nakagawa, S., & Takeichi, M. (1998) · Development · doi:10.1242/dev.125.15.2963 · Cited by 388 · see citing works

Neural crest cell-cell adhesion controlled by sequential and subpopulationspecific expression of novel cadherins

Nakagawa, S., & Takeichi, M. (1995) · Development · doi:10.1242/dev.121.5.1321 · Cited by 372 · see citing works

A Genetic Link between Morphogenesis and Cell Division during Formation of the Ventral Furrow in Drosophila

Großhans, J., & Wieschaus, E. F. (2000) · Cell · doi:10.1016/s0092-8674(00)80862-4 · Cited by 344 · see citing works

The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo.Preprint

Ip, Y. T., Park, R., Kosman, D., Bier, E., & Levine, M. (1992) · Genes & Development · doi:10.1101/gad.6.9.1728 · Cited by 324 · see citing works

Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo

Sefton, M., Sánchez, S., & Nieto, M. A. (1998) · Development · doi:10.1242/dev.125.16.3111 · Cited by 315 · see citing works

Mechanisms of Left–Right Determination in Vertebrates

Capdevila, J., Vogan, K. J., Tabin, C. J., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)80619-4 · Cited by 313 · see citing works

The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers

Boulay, J., Dennefeld, C., & Alberga, A. (1987) · Nature · doi:10.1038/330395a0 · Cited by 310 · see citing works

The Inductive Properties of Mesoderm Suggest That the Neural Crest Cells Are Specified by a BMP Gradient

Marchant, L., Linker, C., Ruiz, P., Guerrero, N., & Mayor, R. (1998) · Developmental Biology · doi:10.1016/s0012-1606(98)80008-0 · Cited by 302 · see citing works

Dorsalization of the neural tube by the non-neural ectoderm

Dickinson, M. E., Selleck, M. A. J., McMahon, A. P., & Bronner-Fraser, M. E. (1995) · Development · doi:10.1242/dev.121.7.2099 · Cited by 300 · see citing works

Snail/Slug family of repressors: slowly going into the fast lane of development and cancer

Hemavathy, K. C., Ashraf, S. I., & Ip, Y. T. (2000) · Gene · doi:10.1016/s0378-1119(00)00371-1 · Cited by 299 · see citing works

Loss of E-cadherin Expression in Melanoma Cells Involves Up-regulation of the Transcriptional Repressor Snail

Poser, I., Dominguez-Sola, D., de Herreros, A. G., Varnai, A., Buettner, R., & Bosserhoff, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011224200 · Cited by 280 · see citing works

The Gfi-1 Proto-Oncoprotein Contains a Novel Transcriptional Repressor Domain, SNAG, and Inhibits G 1 Arrest Induced by Interleukin-2 Withdrawal

Grimes, H. L., Chan, T. O., Zweidler‐McKay, P. A., Tong, B. C., & Tsichlis, P. N. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6263 · Cited by 279 · see citing works

Regulation of the onset of neural crest migration by coordinated activity of BMP4 and Noggin in the dorsal neural tube

Sela‐Donenfeld, D., & Kalcheim, C. (1999) · Development · doi:10.1242/dev.126.21.4749 · Cited by 262 · see citing works

The Slug Gene Is Not Essential for Mesoderm or Neural Crest Development in Mice

Jiang, R., Lan, Y., Norton, C. R., Sundberg, J. P., & Gridley, T. (1998) · Developmental Biology · doi:10.1016/s0012-1606(98)80005-5 · Cited by 260 · see citing works

Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastrulation.

Oda, H., Tsukita, S., & Takeichi, M. (1998) · Developmental Biology · doi:10.1006/dbio.1998.9047 · Cited by 259 · see citing works

Tribbles, a cell-cycle brake that coordinates proliferation and morphogenesis during Drosophila gastrulation

Seher, T. C., & Leptin, M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00502-9 · Cited by 254 · see citing works

Snail-Related Transcriptional Repressors Are Required in Xenopus for both the Induction of the Neural Crest and Its Subsequent Migration

LaBonne, C., & Bronner-Fraser, M. E. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9609 · Cited by 253 · see citing works

Inhibition of integrin linked kinase (ILK) suppresses β-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC−/− human colon carcinoma cells

Tan, C., Costello, P., Sanghera, J. S., Dominguez-Sola, D., Baulida, J., de Herreros, A. G., & Dedhar, S. (2001) · Oncogene · doi:10.1038/sj.onc.1204052 · Cited by 248 · see citing works

Establishment and maintenance of the border of the neural plate in the chick: involvement of FGF and BMP activity

Streit, A., & Stern, C. D. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00013-1 · Cited by 245 · see citing works

A role for rhoB in the delamination of neural crest cells from the dorsal neural tube

Liu, J.-P., & Jessell, T. M. (1998) · Development · doi:10.1242/dev.125.24.5055 · Cited by 242 · see citing works

Overexpression of Snail family members highlights their ability to promote chick neural crest formation

Barrio, M. G. D., & Nieto, M. A. (2002) · Development · doi:10.1242/dev.129.7.1583 · Cited by 230 · see citing works

Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene

Cheng, C., Wu, P., Yu, J., Huang, C., Yue, C., Wu, C., & Shen, C. (2001) · Oncogene · doi:10.1038/sj.onc.1204505 · Cited by 221 · see citing works

Neural Crest Formation in Xenopus laevis: Mechanisms of Xslug Induction

Mancilla, A., & Mayor, R. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0187 · Cited by 214 · see citing works

SLUG, a ces-1-Related Zinc Finger Transcription Factor Gene with Antiapoptotic Activity, Is a Downstream Target of the E2A-HLF Oncoprotein

Inukai, T., Inoue, A., Kurosawa, H., Goi, K., Shinjyo, T., Ozawa, K., Mao, M., Inaba, T., & Look, A. T. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80336-6 · Cited by 211 · see citing works

dCtBP mediates transcriptional repression by Knirps, Krüppel and Snail in the Drosophila embryo

Nibu, Y., Zhang, H., Bajor, E., Barolo, S., Small, S., & Levine, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.23.7009 · Cited by 211 · see citing works

The snail gene required for mesoderm formation in Drosophila is expressed dynamically in derivatives of all three germ layers

Alberga, A., Boulay, J., Kempe, E., Dennefeld, C., & Haenlin, M. (1991) · Development · doi:10.1242/dev.111.4.983 · Cited by 210 · see citing works

Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro

Yokoyama, K., Kamata, N., Hayashi, E., et al. (2001) · Oral Oncology · doi:10.1016/s1368-8375(00)00059-2 · Cited by 209 · see citing works

The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak

Burdsal, C. A., Damsky, C. H., & Pedersen, R. A. (1993) · Development · doi:10.1242/dev.118.3.829 · Cited by 207 · see citing works

Dorsoventral patterning of the vertebrate neural tube is conserved in a protochordate

Corbo, J. C., Erives, A. J., Gregorio, A. D., Chang, A., & Levine, M. (1997) · Development · doi:10.1242/dev.124.12.2335 · Cited by 195 · see citing works

Control of Vertebrate Left-Right Asymmetry by a Snail -Related Zinc Finger Gene

Isaac, A., Sargent, M. G., & Cooke, J. (1997) · Science · doi:10.1126/science.275.5304.1301 · Cited by 193 · see citing works

Role of FGF andNogginin Neural Crest Induction

Mayor, R., Guerrero, N., & Martı́nez, C. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8634 · Cited by 190 · see citing works

Conservation and elaboration of Hox gene regulation during evolution of the vertebrate head

Manzanares, M., Wada, H., Itasaki, N., Trainor, P. A., Krumlauf, R. K., & Holland, P. W. H. (2000) · Nature · doi:10.1038/35048570 · Cited by 188 · see citing works

Slug is an Essential Target of TGFβ2 Signaling in the Developing Chicken Heart

Romano, L. A., & Runyan, R. B. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9750 · Cited by 184 · see citing works

Cloning and developmental expression of Sna, a murine homologue of the Drosophila snail gene

Nieto, M. A., Bennett, M. F., Sargent, M. G., & Wilkinson, D. G. (1992) · Development · doi:10.1242/dev.116.1.227 · Cited by 179 · see citing works

Cadherin-mediated cell adhesion and cell motility in Drosophila trachea regulated by the transcription factor Escargot

Tanaka‐Matakatsu, M., Uemura, T., Oda, H., et al. (1996) · Development · doi:10.1242/dev.122.12.3697 · Cited by 173 · see citing works

Expression ofsnail2,a Second Member of the Zebrafish Snail Family, in Cephalic Mesendoderm and Presumptive Neural Crest of Wild-Type andspadetailMutant Embryos

Thisse, C., Thisse, B., & Postlethwait, J. H. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0007 · Cited by 171 · see citing works

Evolution of neural crest and placodes: amphioxus as a model for the ancestral vertebrate?

Holland, L. Z., & Holland, N. D. (2001) · Journal of Anatomy · doi:10.1046/j.1469-7580.2001.19910085.x · Cited by 171 · see citing works

Cloning and Characterization of ThreeXenopus Slug Promoters Reveal Direct Regulation by Lef/β-Catenin Signaling

Vallin, J., Thuret, R., Giacomello, E., Faraldo, M. M., Thiery, J. P., & Broders, F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103167200 · Cited by 170 · see citing works

From egg to embryo : determinative events in early development

Slack, J. M. W. (1983) · Cambridge University Press eBooks · Cited by 167 · see citing works

Inhibition of Neural Crest Migration in Xenopus Using Antisense Slug RNA

Carl, T. F., Dufton, C., Hanken, J., & Klymkowsky, M. W. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9320 · Cited by 154 · see citing works

An amphioxus snail gene: Expression in paraxial mesoderm and neural plate suggests a conserved role in patterning the chordate embryo

Langeland, J. A., Tomsa, J. M., Jackman, W. R., & Kimmel, C. B. (1998) · Development Genes and Evolution · doi:10.1007/s004270050216 · Cited by 145 · see citing works

Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development

Smith, D. E., del Amo, F. F., & Gridley, T. (1992) · Development · doi:10.1242/dev.116.4.1033 · Cited by 145 · see citing works

The expression of a zebrafish gene homologous to Drosophila snail suggests a conserved function in invertebrate and vertebrate gastrulation

Hammerschmidt, M., & Nüsslein‐Volhard, C. (1993) · Development · doi:10.1242/dev.119.4.1107 · Cited by 144 · see citing works

Human Slug Is a Repressor That Localizes to Sites of Active Transcription

Hemavathy, K. C., Guru, S. C., Harris, J., Chen, J. D., & Ip, Y. T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5087-5095.2000 · Cited by 136 · see citing works

MUTATIONS AND CHROMOSOMAL REARRANGEMENTS AFFECTING THE EXPRESSION OF SNAIL, A GENE INVOLVED IN EMBRYONIC PATTERNING IN DROSOPHILA MELANOGASTER

Grau, Y., Carteret, C., & Simpson, P. (1984) · Genetics · doi:10.1093/genetics/108.2.347 · Cited by 128 · see citing works

The Drosophila gene escargot encodes a zinc finger motif found in snail-related genes

Whiteley, M., Noguchi, P. D., Sensabaugh, S. M., et al. (1992) · Mechanisms of Development · doi:10.1016/0925-4773(92)90063-p · Cited by 127 · see citing works

The C. elegans Cell Death Specification Gene ces-1 Encodes a Snail Family Zinc Finger Protein

Metzstein, M. M., & Horvitz, H. R. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80333-0 · Cited by 126 · see citing works

Diploidy of Drosophila imaginal cells is maintained by a transcriptional repressor encoded by escargot.Preprint

Fuse, N., Hirose, S., & Hayashi, S. (1994) · Genes & Development · doi:10.1101/gad.8.19.2270 · Cited by 126 · see citing works

Identification in Xenopus of a structural homologue of the Drosophila gene Snail

Sargent, M. G., & Bennett, M. F. (1990) · Development · doi:10.1242/dev.109.4.967 · Cited by 124 · see citing works

A family of Snail‐related zinc finger proteins regulates two distinct and parallel mechanisms that mediate Drosophila neuroblast asymmetric divisions

Cai, Y., Chia, W., & Yang, X. (2001) · The EMBO Journal · doi:10.1093/emboj/20.7.1704 · Cited by 121 · see citing works

An ancestral whole-genome duplication may not have been responsible for the abundance of duplicated fish genes

Robinson‐Rechavi, M., Marchand, O., Escrivá, H., & Laudet, V. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00280-9 · Cited by 119 · see citing works

The Transition to Endoreduplication in Trophoblast Giant Cells Is Regulated by the mSNA Zinc Finger Transcription Factor

Nakayama, H., Scott, I. C., & Cross, J. C. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8914 · Cited by 117 · see citing works

The increasing complexity of the Snail gene superfamily in metazoan evolution

Manzanares, M. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02232-6 · Cited by 110 · see citing works

The mesoderm determinant Snail collaborates with related zinc‐finger proteins to control Drosophila neurogenesis

Ashraf, S. I., Hu, X., Roote, J., & Ip, Y. T. (1999) · The EMBO Journal · doi:10.1093/emboj/18.22.6426 · Cited by 110 · see citing works

Hyperactivation of the folded gastrulation pathway induces specific cell shape changes

Morize, P., Christiansen, A. E., Costa, M., Parks, S., & Wieschaus, E. F. (1998) · Development · doi:10.1242/dev.125.4.589 · Cited by 104 · see citing works

scratch, a pan-neural gene encoding a zinc finger protein related to snail, promotes neuronal development.Preprint

Roark, M., Sturtevant, M. A., Emery, J. F., Vaessin, H., Grell, E. H., & Bier, E. (1995) · Genes & Development · doi:10.1101/gad.9.19.2384 · Cited by 101 · see citing works

Control of imaginal cell development by the escargot gene of Drosophila

Hayashi, S., Hirose, S., Metcalfe, A. D., & Shirras, A. D. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90004-2 · Cited by 100 · see citing works

Definition of the DNA-binding site repertoire for theDrosophilatranscription factor SNAIL

Mauhin, V., Lutz, Y., Dennefeld, C., & Alberga, A. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.17.3951 · Cited by 97 · see citing works

Role of FGFs in the control of programmed cell death during limb development

Montero, J. A., Gañán, Y., Macias, D., Rodríguez‐León, J., Sanz‐Ezquerro, J. J., Merino, R., Chimal‐Monroy, J., Nieto, M. A., & Hurlé, J. M. (2001) · Development · doi:10.1242/dev.128.11.2075 · Cited by 97 · see citing works

Relationship between Gene Expression Domains of Xsnail, Xslug, and Xtwist and Cell Movement in the Prospective Neural Crest of Xenopus

Linker, C., Bronner-Fraser, M. E., & Mayor, R. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9723 · Cited by 96 · see citing works

The Snail repressor establishes a muscle/notochord boundary in the Ciona embryo

Fujiwara, S., Corbo, J. C., & Levine, M. (1998) · Development · doi:10.1242/dev.125.13.2511 · Cited by 94 · see citing works

A novel Snail-related transcription factor Smuc regulates basic helix-loop-helix transcription factor activities via specific E-box motifs

Kataoka, H. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.2.626 · Cited by 89 · see citing works

The Snail protein family regulates neuroblast expression ofinscuteableandstring, genes involved in asymmetry and cell division inDrosophila

Ashraf, S. I., & Ip, Y. T. (2001) · Development · doi:10.1242/dev.128.23.4757 · Cited by 89 · see citing works

Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene.

Kasai, Y., Nambu, J. R., Lieberman, P. M., & Crews, S. T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3414 · Cited by 88 · see citing works

Control of imaginal cell development by the escargot gene of Drosophila

Hayashi, S., Hirose, S., Metcalfe, T., & Shirras, A. D. (1993) · Development · doi:10.1242/dev.118.1.105 · Cited by 86 · see citing works

Determination of wing cell fate by the escargot and snail genes in Drosophila

Fuse, N., Hirose, S., & Hayashi, S. (1996) · Development · doi:10.1242/dev.122.4.1059 · Cited by 84 · see citing works

Neural Induction in Whole Chick Embryo Cultures by FGF

Álvarez, I. S., de Araújo, M. C. P. M., & Nieto, M. A. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8903 · Cited by 82 · see citing works

BMP4 Plays a Key Role in Left–Right Patterning in Chick Embryos by Maintaining Sonic Hedgehog Asymmetry

Monsoro-Burq, A. H., & Douarin, N. M. L. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00223-4 · Cited by 78 · see citing works

Mammalian Scratch: A neural-specific Snail family transcriptional repressor

Nakakura, E. K., Watkins, D. N., Schuebel, K. E., Sriuranpong, V., Borges, M. W., Nelkin, B. D., & Ball, D. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051014098 · Cited by 76 · see citing works

Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells: Possible involvement of plakoglobin

Navarro, P., Lozano, E., & Cano, A. (1993) · Journal of Cell Science · doi:10.1242/jcs.105.4.923 · Cited by 70 · see citing works

Slug, a zinc finger gene previously implicated in the early patterning of the mesoderm and the neural crest, is also involved in chick limb development

Ros, M. A., Sefton, M., & Nieto, M. A. (1990) · Development · doi:10.1242/dev.124.9.1821 · Cited by 69 · see citing works

Inhibition of MMH (Met murine hepatocyte) cell differentiation by TGFβ is abrogated by pre-treatment with the heritable differentiation effector FGF1

Spagnoli, F. M., Cicchini, C., Tripodi, M., et al. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.20.3639 · Cited by 65 · see citing works

Identification of conserved C2H2 zinc-finger gene families in the Bilateria

Knight, R. D., & Shimeld, S. M. (2001) · Genome biology · doi:10.1186/gb-2001-2-5-research0016 · Cited by 62 · see citing works

A novel function for the Xslug gene: control of dorsal mesendoderm development by repressing BMP-4

Mayor, R., Guerrero, N., Young, R., Gómez-Skármeta, J. L., & Cuellar, C. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00412-3 · Cited by 60 · see citing works

Genomic Organization, Expression, and Chromosome Location of the Human SNAIL Gene (SNAI1) and a Related Processed Pseudogene (SNAI1P)

Paznekas, W. A., Okajima, K., Schertzer, M., et al. (1999) · Genomics · doi:10.1006/geno.1999.6010 · Cited by 56 · see citing works

Snail is an immediate early target gene of parathyroid hormone related peptide signaling in parietal endoderm formation

Veltmaat, J. M., Orelio, C. C., Oostwaard, D. W., van Rooijen, M., Mummery, C. L., & Defize, L. H. K. (2000) · The International Journal of Developmental Biology · doi:10.1387/ijdb.10853826 · Cited by 54 · see citing works

Cloning and embryonic expression of Hrsna, a snail family gene of the ascidian Halocynthia roretzi: Implication in the origins of mechanisms for mesoderm specification and body axis formation in chordates

Wada, S., & Saiga, H. (1999) · Development Growth & Differentiation · doi:10.1046/j.1440-169x.1999.00408.x · Cited by 51 · see citing works

Expression patterns of twist and snail in Tribolium (Coleoptera) suggest a homologous formation of mesoderm in long and short germ band insects

Sommer, R. J., & Tautz, D. (1994) · Developmental Genetics · doi:10.1002/dvg.1020150105 · Cited by 51 · see citing works

Characterisation of the human snail ( SNAI1 ) gene and exclusion as a major disease gene in craniosynostosis

Twigg, S. R. F., & Wilkie, A. O. M. (1999) · Human Genetics · doi:10.1007/s004399900143 · Cited by 29 · see citing works

Mammalian Scratch participates in neuronal differentiation in P19 embryonal carcinoma cells

Nakakura, E. K., Watkins, D. N., Sriuranpong, V., et al. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00246-7 · Cited by 25 · see citing works

Dorsal and Snail homologs in leech development

Goldstein, B., Leviten, M., & Weisblat, D. (2001) · Development, Genes and Evolution · doi:10.1007/s004270100160 · Cited by 22 · see citing works

Expression of the transcription factor slug correlates with growth of the limb bud and is regulated by FGF-4 and retinoic acid

Buxton, P., Kostakopoulou, K., Brickell, P. M., et al. (1997) · The International Journal of Developmental Biology · doi:10.1387/ijdb.9303343 · Cited by 22 · see citing works

Identification and analysis of two snail genes in the pufferfish (Fugu rubripes) and mapping of human SNA to 20q

Smith, S. F., Metcalfe, J. A., & Elgar, G. (2000) · Gene · doi:10.1016/s0378-1119(00)00110-4 · Cited by 16 · see citing works

Snail-type zinc finger proteins prevent neurogenesis in Scutoid and transgenic animals of Drosophila

Fuse, N., Matakatsu, H., Taniguchi, M., et al. (1999) · Development Genes and Evolution · doi:10.1007/s004270050291 · Cited by 14 · see citing works

Localization of a neural crest transcription factor, Slug, to mouse Chromosome 16 and human Chromosome 8

Rhim, H., Savagner, P., Thibaudeau, G., et al. (1997) · Mammalian Genome · doi:10.1007/s003359900601 · Cited by 11 · see citing works

Heterologous Expression of the Transcriptional Regulator Escargot Inhibits Megakaryocytic Endomitosis

Ballester, A., Frampton, J., Vilaboa, N. E., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106006200 · Cited by 7 · see citing works

ORGANIZATION OF CELLS INTO HIGHER ORDERED STRUCTURES

Erickson, C. A. (2000) · Elsevier eBooks · doi:10.1016/b978-012436630-5/50007-6 · Cited by 1 · see citing works

Cellular senescence and cancer

(1999) · doi:10.1002/(sici)1096-9896(199901)187:1

The basics of epithelial-mesenchymal transition

Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196 · see citing works

Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?

Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121 · see citing works

TGF-β-induced epithelial to mesenchymal transition

Xu, J., Lamouille, S., & Derynck, R. (2009) · Cell Research · doi:10.1038/cr.2009.5 · Cited by 2,804 · see citing works

Guidelines and definitions for research on epithelial-mesenchymal transition

Yang, J., Antin, P., Berx, G., Blanpain, C., Brabletz, T., Bronner, M., Campbell, K., Cano, A., Casanova, J., Christofori, G., et al. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0237-9 · Cited by 2,226 · see citing works

Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition

Zhou, B. P., Deng, J., Xia, W., Xu, J., Li, Y. M., Gunduz, M., & Hung, M.-C. (2004) · Nature Cell Biology · doi:10.1038/ncb1173 · Cited by 1,581 · see citing works

Regulation of tight junctions during the epithelium-mesenchyme transition:direct repression of the gene expression of claudins/occludin by Snail

Ikenouchi, J., Matsuda, M., Furuse, M., & Tsukita, S. (2003) · Journal of Cell Science · doi:10.1242/jcs.00389 · Cited by 678 · see citing works

Non-redundant functions of EMT transcription factors

Stemmler, M. P., Eccles, R. L., Brabletz, S., & Brabletz, T. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0196-y · Cited by 524 · see citing works

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

Wang, S.-P., Wang, W.-L., Chang, Y.-L., Wu, C.-T., Chao, Y.-C., Kao, S.-H., Yuan, A., Lin, C.-W., Yang, S.-C., Chan, W.-K., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1875 · Cited by 493 · see citing works

Conserved Patterns of Cell Movements during Vertebrate Gastrulation

Solnica-Krezel, L. (2005) · Current Biology · doi:10.1016/j.cub.2005.03.016 · Cited by 391 · see citing works

Pathogenesis of uterine adenomyosis, invagination or metaplasia?

García-Solares, J., Donnez, J., Donnez, O., & Dolmans, M.-M. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.12.030 · Cited by 339 · see citing works

The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation

Ohkubo, T., & Ozawa, M. (2004) · Journal of Cell Science · doi:10.1242/jcs.01004 · Cited by 322 · see citing works

Regulation of E-cadherin Expression by <i>VHL</i> and Hypoxia-Inducible Factor

Esteban, M. A., Tran, M. G. B., Harten, S. K., Hill, P., Castellanos, M. C., Chandra, A., Raval, R., O'Brien, T. S., & Maxwell, P. H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2670 · Cited by 262 · see citing works

The morphological and molecular features of the epithelial-to-mesenchymal transition

Moreno-Bueno, G., Peinado, H., Molina, P., Olmeda, D., Cubillo, E., Santos, V., Palacios, J., Portillo, F., & Cano, A. (2009) · Nature Protocols · doi:10.1038/nprot.2009.152 · Cited by 221 · see citing works

MDM2 Promotes Cell Motility and Invasiveness by Regulating E-Cadherin Degradation

Yang, J.-Y., Zong, C. S., Xia, W., Wei, Y., Ali-Seyed, M., Li, Z., Broglio, K., Berry, D. A., & Hung, M.-C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00172-06 · Cited by 211 · see citing works

Angiopoietin-2 Stimulates Breast Cancer Metastasis through the α5β1 Integrin-Mediated Pathway

Imanishi, Y., Hu, B., Jarzynka, M. J., Guo, P., Elishaev, E., Bar-Joseph, I., & Cheng, S.-Y. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4100 · Cited by 190 · see citing works

Analysis of forkhead and snail expression reveals epithelial–mesenchymal transitions during embryonic and larval development of Nematostella vectensis

Fritzenwanker, J. H., Saina, M., & Technau, U. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.08.014 · Cited by 165 · see citing works

Bacterial induction of Snail1 contributes to blood-brain barrier disruption

Kim, B. J., Hancock, B. M., Bermudez, A., Cid, N. D., Reyes, E., van Sorge, N. M., Lauth, X., Smurthwaite, C. A., Hilton, B. J., Stotland, A., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci74159 · Cited by 145 · see citing works

A simple plan-Cnidarians and the origins of developmental mechanisms

Ball, E. E., Hayward, D. C., Saint, R., & Miller, D. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1402 · Cited by 123 · see citing works

Mouse Snail Is a Target Gene for HIF

Luo, D., Wang, J., Li, J., & Post, M. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0214 · Cited by 116 · see citing works

The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging

Zhu, P., Zhang, C., Gao, Y., Wu, F., Zhou, Y., & Wu, W.-S. (2019) · Nature Communications · doi:10.1038/s41467-019-10479-4 · Cited by 66 · see citing works

Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium

Gross, K. M., Zhou, W., Breindel, J. L., Ouyang, J., Jin, D. X., Sokol, E. S., Gupta, P. B., Huber, K., Zou, L., & Kuperwasser, C. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.043 · Cited by 58 · see citing works

Estrone, the major postmenopausal estrogen, binds ERa to induce SNAI2, epithelial-to-mesenchymal transition, and ER+ breast cancer metastasis

Qureshi, R., Picon-Ruiz, M., Sho, M., Van Booven, D., Nunes de Paiva, V., Diaz-Ruano, A. B., Ince, T. A., & Slingerland, J. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111672 · Cited by 37 · see citing works

Dihydroartemisinin protects blood–brain barrier permeability during sepsis by inhibiting the transcription factor <scp>SNAI1</scp>

Liu, F., Liu, J., Xiang, H., Sun, Z., Li, Y., Li, X., Liu, Y., & Liu, J. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13683 · Cited by 9 · see citing works

Cellular‐resolution gene expression mapping reveals organization in the head ganglia of the gastropod, <i>Berghia stephanieae</i>

Ramirez, M. D., Bui, T. N., & Katz, P. S. (2024) · Journal of Comparative Neurology · doi:10.1002/cne.25628 · Cited by 10 · see citing works

3SY07-5 Roles of KLF5/BTEB, a Kr ppel-like zinc-finger type transcription factor, in vascular remodeling

Nagai, R. (2003) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(03)90773-2

Progress of Krüppel-like factor 4 in tumorigenesis

Song, E., & Zhang, X. (2013) · Int J Genet · doi:10.3760/cma.j.issn.1673-4386.2013.02.003

OE-114 Kruppel-like Zinc-finger Transcription Factor KLF5/BTEB2 is an Essential Regulator of Cardiovascular Remodeling(Atherosclerosis, Basic 1 (IHD) : OE14)(Oral Presentation (English))

Shindo, T., Manabe, I., Suzuki, T., et al. (2004) · Japanese Circulation Journal-english Edition

Two new species of amphipods of the superfamily aoroidea (Crustacea: Corophiidea) from the strait of Malacca, Malaysia, with a description of a new genus

Abdul, B., Rahim, A. B. A., & Othman, B. H. R. (2012) · Cited by 9 · see citing works

Molecular characterization of the Krüppel-homolog 1 and its role in ovarian development in Sogatella furcifera (Hemiptera: Delphacidae)

Hu, K., Tian, P., Lü, Y., et al. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-05206-7 · Cited by 28 · see citing works