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Soluble 80‐kd fragment of cell‐CAM 120/80 disrupts cell‐cell adhesion
Abstract
Calcium‐dependent cell adhesion molecules (CAMs) mediate intercellular adhesion in epithelial cells and in preimplantation mammalian embryos. One of these molecules, cell‐CAM 120/80, is found on cells as a 120‐kd membrane glycoprotein and as a soluble 80‐kd species in conditioned culture medium [Damsky et al: Cell 34:455, 1983]. We have purified to homogeneity the soluble 80‐kd fragment of cell‐CAM 120/80 by using monoclonal antibody affinity chromatography. We have shown that the purified molecule can disrupt cell‐cell adhesion in cultured epithelial cells, thus indicating that it is directly involved in the adhesive process. In addition, we have further characterized both the 120‐kd cell‐associated molecule and its 80‐kd fragment, including N‐terminal sequence analysis.
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Citations
Cited by
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Loh, C.-Y., Chai, J., Tang, T., Wong, W., Sethi, G., Shanmugam, M., Chong, P., & Looi, C. (2019) · Cells · doi:10.3390/cells8101118 · Cited by 1,315
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Takeichi, M. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.001321 · Cited by 1,306
Zhou, Y., Fisher, S. J., Janatpour, M., Genbacev, O., Dejana, E., Wheelock, M., & Damsky, C. H. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119387 · Cited by 959
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Metadata
- Authors
- Wheelock, M. J., Buck, C. A., Bechtol, K. B., & Damsky, C. H.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 1987-07
- Volume
- 34
- Issue
- 3
- Pages
- 187-202
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2053758478
- Cited by
- 236
- References
- 0
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Soluble 80‐kd fragment of cell‐CAM 120/80 disrupts cell‐cell adhesion. https://app.cochat.ai/papers/10.1002/jcb.240340305
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- Wheelock, M. J., Buck, C. A., Bechtol, K. B., & Damsky, C. H. (1987). Soluble 80‐kd fragment of cell‐CAM 120/80 disrupts cell‐cell adhesion. Journal of Cellular Biochemistry. https://doi.org/10.1002/jcb.240340305
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