The DOI matches its Crossref record; 266 of the 266 references it cites were found in a registry or an index.
The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges
Open accessAbstract
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due to its emerging role as a pivotal driver of tumorigenesis, targeting EMT is of great therapeutic interest in counteracting metastasis and chemoresistance in cancer patients. The hallmark of EMT is the upregulation of N-cadherin followed by the downregulation of E-cadherin, and this process is regulated by a complex network of signaling pathways and transcription factors. In this review, we summarized the recent understanding of the roles of E- and N-cadherins in cancer invasion and metastasis as well as the crosstalk with other signaling pathways involved in EMT. We also highlighted a few natural compounds with potential anti-EMT property and outlined the future directions in the development of novel intervention in human cancer treatments. We have reviewed 287 published papers related to this topic and identified some of the challenges faced in translating the discovery work from bench to bedside.
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Cites
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HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS
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Cited by
Datta, A., Deng, S., Gopal, V., Yap, K. C.-H., Halim, C. E., Lye, M. L., Ong, M. S., Tan, T. Z., Sethi, G., Hooi, S. C., et al. (2021) · Cancers · doi:10.3390/cancers13081882 · Cited by 184
Self-citationTGF-β signaling networks in the tumor microenvironment
Chan, M. K.-K., Chung, J. Y.-F., Tang, P. C.-T., Chan, A. S.-W., Ho, J. Y.-Y., Lin, T. P.-T., Chen, J., Leung, K.-T., To, K.-F., Lan, H.-Y., et al. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215925 · Cited by 90
Li, S., Li, L., Lin, X., Chen, C., Luo, C., & Huang, Y. (2022) · ACS Nano · doi:10.1021/acsnano.1c06022 · Cited by 78
Drury, J., Rychahou, P. G., Kelson, C. O., Geisen, M. E., Wu, Y., He, D., Wang, C., Lee, E. Y., Evers, B. M., & Zaytseva, Y. Y. (2022) · Cancers · doi:10.3390/cancers14010252 · Cited by 64
Cell adhesion molecules in fibrotic diseases
Hu, Q., Saleem, K., Pandey, J., Charania, A. N., Zhou, Y., & He, C. (2023) · Biomedicines · doi:10.3390/biomedicines11071995 · Cited by 32
Metadata
- Authors
- Loh, C.-Y., Chai, J., Tang, T., Wong, W., Sethi, G., Shanmugam, M., Chong, P., & Looi, C.
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2019-09-20
- Volume
- 8
- Issue
- 10
- Pages
- 1118
- ISSN
- 2073-4409 (ISSN-L)
- OpenAlex
- W2974147039
- Cited by
- 1,315
- References
- 266
- FWCI
- 44.53
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges. https://app.cochat.ai/papers/10.3390/cells8101118
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- Loh, C.-Y., Chai, J., Tang, T., Wong, W., Sethi, G., Shanmugam, M., Chong, P., & Looi, C. (2019). The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges. Cells. https://doi.org/10.3390/cells8101118
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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