The DOI matches its Crossref record; 83 of the 86 references it cites were found in a registry or an index.
Role of N‐cadherin in bone formation
Abstract
Cell–cell adhesion mediated by cadherins is essential for the function of bone forming cells during osteogenesis. Here, the evidence that N‐cadherin is an important regulator of osteoblast differentiation and osteogenesis is reviewed. Osteoblasts express a limited number of cadherins, including the classic N‐cadherin. The expression profile of N‐cadherin in osteoblasts during bone formation in vivo and in vitro suggests a role of this molecule in osteogenesis. Functional studies using neutralizing antibodies or antisense oligonucleotides indicate that N‐cadherin is involved in the control the expression of osteoblast marker gene expression and differentiation. Cleavage of N‐cadherin during osteoblast apoptosis also suggests a role of N‐cadherin‐mediated‐cell–cell adhesion in osteoblast survival. Hormonal and local factors that regulate osteoblast function also regulate N‐cadherin expression and subsequent cell–cell adhesion associated with osteoblast differentiation or survival. Signaling mechanisms involved in N‐cadherin‐mediated cell–cell adhesion and osteoblast gene expression have also been identified. Alterations of N‐cadherin expression are associated with abnormal osteoblast differentiation and osteogenesis in pathological conditions. These findings indicate that N‐cadherin plays a role in normal and pathological bone formation and provide some insight into the process involved in N‐cadherin‐mediated cell–cell adhesion and differentiation in osteoblasts. J. Cell. Physiol. 190: 297–305, 2002. © 2002 Wiley‐Liss, Inc.
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“Osteoblasts make interactions with bone matrix by integrins, which recognize and bind to RGD and other sequences present in bone matrix proteins including osteopontin, fibronectin, collagen, osteopontin, and bone sialoprotein [130, 131].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [131]
Citations
Cites
Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis
Gumbiner, B. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81279-9 · Cited by 3,471
Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator
Takeichi, M. (1991) · Science · doi:10.1126/science.2006419 · Cited by 3,283
Therapeutic Approaches to Bone Diseases
Rodan, G. A., & Martin, T. J. (2000) · Science · doi:10.1126/science.289.5484.1508 · Cited by 1,767
Protein Kinase C: Structure, Function, and Regulation
Newton, A. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.48.28495 · Cited by 1,656
Morphogenetic roles of classic cadherins
Takeichi, M. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80102-2 · Cited by 1,467
Compston, J. E. (1997) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1997.2431019.x · Cited by 1,383
Stein, G. S., Lian, J. B., & Owen, T. A. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.13.2210157 · Cited by 931
Aplin, A. E., Howe, A. K., Alahari, S. K., & Juliano, R. L. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01359-0 · Cited by 858
Cellular interactions and signaling in cartilage development
DeLise, A. M., Fischer, L., & Tuan, R. S. (2000) · Osteoarthritis and Cartilage · doi:10.1053/joca.1999.0306 · Cited by 789
Developmental Defects in Mouse Embryos Lacking N-Cadherin
Radice, G. L., Rayburn, H., Matsunami, H., Knudsen, K. A., Takeichi, M., & Hynes, R. O. (1997) · Developmental Biology · doi:10.1006/dbio.1996.8443 · Cited by 723
Research works printed but not linked: 8
- Globus RK, 1995, Integrin‐extracellular matrix interactions in connective tissue remodeling and osteoblast differentiation, ASGSB Bull, 8, 19
- 10.1002/(SICI)1097-4644(1998)72:30/31 <168::AID-JCB21>3.0.CO;2-V · DOI
- Le Mée S, 2001, Cloning of the human N‐cadherin promoter: functional analysis of a G.C‐rich region and regulatory elements [abstract], J Bone Miner Res, 16, S489
- Lomri A, 1998, Increased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor‐2 mutations in Apert syndrome, J Clin Invest, 101, 1310
- Marie PJ, 1997, Effects of bone morphogenetic proteins on cells of the osteoblastic lineage, J Cell Eng, 2, 92
- Marie PJ, 1999, Advances in organ biology: molecular and cellular biology of bone, 401
- Suva LJ, 1994, Hormonal regulation of osteoblast‐derived cadherin expression in vitro and in vivo, J Bone Miner Res, 9, S123
- Triffitt JT, 1996, Principles of bone biology, 39
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García, D. F. (2011) · Institutional Repository of the University of Granada (University of Granada)
Hwang, S. K., Kim, M. Y., Lim, Y. J., Jang, S. M., Paik, S. S., Koh, H. C., & Lee, Y. H. (2009) · Imsang soa hyeoraek jong-yang/Imsang soa hyeol'aeg jong'yang/Clinical pediatric hematology-oncology
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Na, M. (2015) · Scholarship@Western (Western University)
Hendawy, H. A. E., Ibrahiem, A. T., Sy, E.-N., & Zedan, W. (2017) · Journal of Solid Tumors · doi:10.5430/jst.v8n1p19
Ratheesh, G. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.210168
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Feng, J. C., Zhang, H., Wu, S., Qi, G., & Wang, J. (2020) · Figshare · doi:10.6084/m9.figshare.13212391
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Feng, J., Zhang, H.-J., Wu, S.-G., Qi, G.-H., & Wang, J. (2020) · Figshare · doi:10.6084/m9.figshare.13212388
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Feng, J., Zhang, H.-J., Wu, S.-G., Qi, G.-H., & Wang, J. (2020) · Figshare · doi:10.6084/m9.figshare.13212409
Feng, J., Zhang, H.-J., Wu, S.-G., Qi, G.-H., & Wang, J. (2020) · Figshare · doi:10.6084/m9.figshare.13212403
Metadata
- Authors
- Marie, P. J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Marie, Pierre J.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2002-01-24
- Volume
- 190
- Issue
- 3
- Pages
- 297-305
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2052361599
- Cited by
- 132
- References
- 86
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 11 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 7 · 2013: 7 · 2012: 7
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- N-cadherin, bone formation, osteogenic differentiation, cell-cell adhesion, osteoblast apoptosis, osteoblast survival, cadherin signaling
- MeSH terms
- Animals, Bone Diseases, Cell Adhesion, Cell Differentiation, Humans, Osteoblasts, Osteogenesis, Cadherins, Chondrogenesis
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