The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Cancer/testis‐associated genes: Identification, expression profile, and putative function
Abstract
Cancer/testis‐associated genes (CTAs) are a subgroup of tumor antigens with a restricted expression in testis and malignancies. During the last decade, many of these immunotherapy candidate genes have been discovered using various approaches. Most of these genes are localized on the X‐chromosome, often as multigene families. Methylation status seems to be the main, but not the only regulator of their specific expression pattern. In testis, CTAs are exclusively present in cells of the germ cell lineage, though there is a lot of variation in the moment of expression during different stages of sperm development. Likewise, there is also a lot of heterogeneity in the expression of CTAs in melanoma samples. Clues regarding functionality of CTAs for many of these proteins point to a role in cell cycle regulation or transcriptional control. Better insights in the function of these genes may shed light on the link between spermatogenesis and tumor growth and could be of use in anti‐tumor therapies. This review outlines the CTA family and focuses on their expression and putative function during male germ cell development and melanocytic tumor progression. © 2003 Wiley‐Liss, Inc.
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Cited by
The biology of cancer testis antigens: Putative function, regulation and therapeutic potential
Fratta, E., Coral, S., Covre, A., Parisi, G., Colizzi, F., Danielli, R., Marie Nicolay, H. J., Sigalotti, L., & Maio, M. (2011) · Molecular Oncology · doi:10.1016/j.molonc.2011.02.001 · Cited by 375
Metadata
- Authors
- Zendman, A. J. W., Ruiter, D. J., & Van Muijen, G. N. P.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2003-01-23
- Volume
- 194
- Issue
- 3
- Pages
- 272-288
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2079842158
- Cited by
- 255
- References
- 135
- FWCI
- 24.76
- Type
- journal article
- Language
- en
- Open access
- closed
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