The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Neoplastic differentiation: Characteristics of cell lines derived from a murine teratocarcinoma
Abstract
Monolayer cultures of a mouse teratocarcinoma were established in vitro. These cultures contained embryonal carcinoma, the malignant stem cell, and its differentiated progeny: parietal yolk sac, neuroepithelial, and mesenchymal cells. Tissues such as squamous epithelium, cartilage, striated muscle, neuroepithelium, and glands were produced from embryonal carcinoma that was maintained under conditions of long term culture. Frequent subcultivation with pancreatin allowed the establishment of cell lines of embryonal carcinoma which have been maintained for more than 18 months in vitro and continue to produce differentiated cells under specific culture conditions. Chromosomally these lines of embryonal carcinoma have a stem line of 39 chromosomes. Two lines of parietal yolk sac cells have been established which produce basement membrane, are not tumorigenic, and chromosomally are hypotetraploid. This system may yield information concerning neoplastic differentiation and its possible use in therapy for cancer.
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Citations
Cites
Cell population kinetics in the intestinal epithelium of the mouse
Quastler, H., & Sherman, F. G. (1959) · Experimental Cell Research · doi:10.1016/0014-4827(59)90063-1 · Cited by 1,417
MULTIPOTENTIALITY OF SINGLE EMBRYONAL CARCINOMA CELLS.
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Self-citationAssay of tyrosine hydroxylase by coupled decarboxylation of dopa formed from 1-14C-l-tyrosine
Waymire, J. C., Bjur, R., & Weiner, N. (1971) · Analytical Biochemistry · doi:10.1016/0003-2697(71)90291-0 · Cited by 459
Spontaneous Testicular Teratomas in an Inbred Strain of Mice
Stevens, L. C., & Little, C. C. (1954) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.40.11.1080 · Cited by 379
Origin of Testicular Teratomas From Primordial Germ Cells in Mice 2
(1967) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/38.4.549 · Cited by 320
Differentiation of malignant to benign cells
Kauffman, S. (1971) · Journal of Theoretical Biology · doi:10.1016/0022-5193(71)90020-8 · Cited by 309
Chapter 8: Teratocarcinoma: Model for A Developmental Concept of Cancer
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Self-citationEXPERIMENTAL PRODUCTION OF TESTICULAR TERATOMAS IN MICE
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Developmental Potentialities of Clonal In Vitro Cultures of Mouse Testicular Teratoma 2
(1970) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/44.5.1015 · Cited by 194
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Cited by
Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma
Rheinwald, J. G., & Green, H. (1975) · Cell · doi:10.1016/0092-8674(75)90183-x · Cited by 1,122
(2008) · Advances in Cancer Research · doi:10.1016/s0065-230x(07)99002-8 · Cited by 203
Metadata
- Authors
- Lehman, J. M., Speers, W. C., Swartzendruber, D. E., & Pierce, G. B.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 1974-08
- Volume
- 84
- Issue
- 1
- Pages
- 13-27
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2067546678
- Cited by
- 353
- References
- 12
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lehman, J. M., Speers, W. C., Swartzendruber, D. E., & Pierce, G. B. (1974). Neoplastic differentiation: Characteristics of cell lines derived from a murine teratocarcinoma. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.1040840103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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