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Developmental Potentialities of Clonal In Vitro Cultures of Mouse Testicular Teratoma 2
Abstract
A transplantable testicular teratocarcinoma from strain 129/J mice was cloned in vitro. Thirty-five clonal and subclonal cultures were isolated and tested for their ability to differentiate when injected into host mice. All clonal cultures produced tumors containing multiple differentiations; those appearing most frequently were neural tissue, mesenchyme, parietal yolk sac, cartilage, and nonciliated epithelium. The stability of the potentialities of cultured clonal cells during their long-term propagation in vitro was examined. Clonal lines retained the potential to produce multiply differentiated tumors even after continuous in vitro culture for over 10 months (119 generations). Limited in vitro differentiation of teratoma cells was observed, including neural tissue, mesenchyme, and parietal yolk sac.
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Citations
Cited by
Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma
Rheinwald, J. G., & Green, H. (1975) · Cell · doi:10.1016/0092-8674(75)90183-x · Cited by 1,122
Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells.
Jones-Villeneuve, E. M., McBurney, M. W., Rogers, K. A., & Kalnins, V. I. (1982) · The Journal of cell biology · doi:10.1083/jcb.94.2.253 · Cited by 781
Neoplastic differentiation: Characteristics of cell lines derived from a murine teratocarcinoma
Lehman, J. M., Speers, W. C., Swartzendruber, D. E., & Pierce, G. B. (1974) · Journal of Cellular Physiology · doi:10.1002/jcp.1040840103 · Cited by 353
From teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stem cell research
Solter, D. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1827 · Cited by 326
Retinoic acid-induced neural differentiation of embryonal carcinoma cells.
Jones-Villeneuve, E. M., Rudnicki, M. A., Harris, J. F., & McBurney, M. W. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.12.2271 · Cited by 313
Metadata
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1970-05
- Volume
- 44
- Issue
- 5
- Pages
- 1015-36
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W1900275326
- Cited by
- 194
- References
- 0
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Developmental Potentialities of Clonal In Vitro Cultures of Mouse Testicular Teratoma 2. (1970). JNCI: Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/44.5.1015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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