Cited by 247Pharmacogenetics and Drug MetabolismToxic Organic Pollutants ImpactMetal-Catalyzed Oxygenation Mechanisms

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse

Nebert, Daniel W., Robinson, Joseph R., Niwa, Akira, Kumari, Kenji, Poland, Alan P.·1975·Journal of Cellular Physiology

Open this paper in CoChat — free account

Abstract

Monooxygenases require NADPH and molecular oxygen during the metabolism of numerous endogenous hydrophobic substrates and carcinogenic and toxic exogenous chemicals. The complexity of these membrane-bound multicomponent drug-metabolizing enzyme systems is reviewed. What "aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity" actually represents is reviewed and discussed. At least two forms of the hydroxylase activity exist and we suggest that they are associated with different molecular species of membrane-bound CO-binding hemoprotein (i.e., they are associated with different enzyme active-sties). At least two, and probably more than two, nonlinked loci are responsible for the genetic expression of new cytochrome P1450 formation and aryl hydrocarbon hydroxylase induction--and the stimulation of 10 other monooxygenase "activities"--in the mouse treated with certain aromatic hydrocarbons. The individual variability of hydroxylase activity in an inbred and in a random-bred strain of micr is illustrated. The basal hydroxylase activity appears to be inherited differently from the aromatic hydrocarbon-inducible hydroxylase activity. The potent inducer 2,3,7,8-tetrachlorodibenzo-p-dioxin can stimulate increases in these hepatic monooxygenase activities and p1450 formation in so-called "nonresponsive" mice, whereas inducers such as beta-naphthoflavone and 3-methylcholanthrene cannot. Thus, the genetically "nonresponsive" micr apparently possess the structural and regulatory genes ne…

Integrity signals

Registry

Crossref · 10.1002/jcp.1040850407

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

PHARMACOLOGICAL IMPLICATIONS OF MICROSOMAL ENZYME INDUCTION
Conney, A. H. (1967) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07146-7 · Cited by 2,942
Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture
Nebert, D. W., & Gelboin, H. V. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94484-4 · Cited by 1,682
Self-citation
Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide
Sims, P. H., Grover, P. L., Swaisland, A. J., Pal, K., & Hewer, A. J. (1974) · Nature · doi:10.1038/252326a0 · Cited by 1,134
Arene Oxides: A New Aspect of Drug Metabolism
JERINA, D. M., & Daly, J. W. (1974) · Science · doi:10.1126/science.185.4151.573 · Cited by 1,039
Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds
Oesch, F. (1973) · Xenobiotica · doi:10.3109/00498257309151525 · Cited by 824
UPTAKE OF RADIOACTIVE ALANINE IN VITRO INTO THE PROTEINS OF RAT LIVER FRACTIONS
Siekevitz, P. (1952) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55763-x · Cited by 686
Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds
Daly, J. W., JERINA, D. M., & Witkop, B. (1972) · Cellular and Molecular Life Sciences · doi:10.1007/bf01946135 · Cited by 599
Aryl Hydrocarbon Hydroxylase Inducibility and Bronchogenic Carcinoma
Kellermann, G. H., Shaw, C. R., & Luyten-Kellerman, M. (1973) · New England Journal of Medicine · doi:10.1056/nejm197311012891802 · Cited by 592
Benzpyrene hydroxylase activity in the gastrointestinal tract.
Lw, W., Leong, J. L., & STRAND, P. J. (1962) · PubMed · Cited by 331
Genetic Expression of Aryl Hydrocarbon Hydroxylase Activity
Poland, A., Glover, E. A., Robinson, J. R., & Nebert, D. W. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)79769-3 · Cited by 329
Self-citation

Show all 56 references

Research works printed but not linked: 19

Conney, 1967, Pharmacol. Rev., 19, 317
and 1975 Properties of purified cytochrome P-450 and NADPH-cytochrome P-450 reductase from rabbit liver microsomes. Adv. Exp. Med. Biol., in press.
1971 Probit Analysis. Cambridge University Press, London, 333 pp.
Goujon, 1972, Mol. Pharmacol., 8, 667
Kellermann, 1973a, Amer. J. Human Genet., 25, 327
Mason, 1975, Adv. Enzymol., 19, 79
Nebert, 1972, Fed. Proc., 31, 1315
Nebert, 1972a, Mol. Pharmacol., 8, 651
Nebert, 1973b, Genetic specificity resides in the fraction containing cytochromes P448 and P450. J. Biol. Chem., 248, 7631
Oesch, 1973, Mol. Pharmacol., 9, 692
Poland, 1973, Mol. Pharmacol., 9, 736
Poland, 1974, Mol. Pharmacol., 10, 349
Poppers, 1974, Pharmacologist, 16, 262
Rasmussen, 1974, Cancer Res., 34, 2290
and 1975 Pharmacogenetic aspects of drug toxicity and teratogenesis in the newborn. In: Perinatal Pharmacology. F. Sereni, S. Garattini and P. L. Morselli, eds., in press.
Robinson, 1974, Mol. Pharmacol., 10, 484
Staats, 1972, Cancer Res., 32, 1609
Thorgeirsson, 1974, Pharmacologist, 16, 277
Wattenberg, 1962, Cancer Res., 22, 1120

Sorted by citations

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase
Poland, A., Glover, E., & Kende, A. S. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33205-2 · Cited by 1,370
Self-citation
The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression
Beischlag, T. V., Morales, J. L., Hollingshead, B. D., & Perdew, G. H. (2008) · Critical Reviews™ in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v18.i3.20 · Cited by 727
The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor
Nguyen, L. P., & Bradfield, C. A. (2007) · Chemical Research in Toxicology · doi:10.1021/tx7001965 · Cited by 718
Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans
Safe, S. H. (1986) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.26.040186.002103 · Cited by 710
Xenobiotic-Metabolizing Enzymes Involved in Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons
Shimada, T. (2006) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.21.257 · Cited by 606
Aldehyde Dehydrogenases and Their Role in Carcinogenesis
Lindahl, R. G. (1992) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239209082565 · Cited by 402
Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation.
Okey, A. B., Bondy, G., Mason, M. E., Kahl, G. F., Eisen, H. J., Guenthner, T. M., & Nebert, D. W. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86532-8 · Cited by 399
Self-citation
Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds
Safe, S. H. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)00017-b · Cited by 357
TheAhLocus: Genetic Regulation of the Metabolism of Carcinogens, Drugs, and Other Environmental Chemicals by Cytochrome P-450-Mediated Monooxygenase
Nebert, D. W., Jensen, N. M., & Gelboin, H. V. (1979) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409237909105427 · Cited by 314
Self-citation
Radioactive assay for aryl hydrocarbon hydroxylase. Improved method and biological importance
CANTFORT, J. V., GRAEVE, J. D., & GIELEN, J. E. (1977) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(77)90186-3 · Cited by 265
Role of the Aryl Hydrocarbon Receptor in Carcinogenesis and Potential as a Drug Target
Safe, S. H., Lee, S., & Jin, U.-H. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft128 · Cited by 281
An Aryl Hydrocarbon Receptor Odyssey to the Shores of Toxicology: The Deichmann Lecture, International Congress of Toxicology-XI
Okey, A. B. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm096 · Cited by 264
Induction of multiple forms of mouse liver cytochrome P-450. Evidence for genetically controlled de novo protein synthesis in response to treatment with beta-naphthoflavone or phenobarbital.
Haugen, D. A., Coon, M. J., & Nebert, D. W. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33722-5 · Cited by 227
Self-citation
CYP1A Induction and Human Risk Assessment: An Evolving Tale of in Vitro and in Vivo Studies
Ma, Q., & Lu, A. Y. H. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.015826 · Cited by 215
Gradients of O2 concentration in hepatocytes.
Jones, D. P., & Mason, H. S. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34627-6 · Cited by 187
The Ah Locus and the Metabolism of Chemical Carcinogens and Other Foreign Compounds
Thorgeirsson, S. S., & Nebert, D. W. (1977) · Advances in cancer research · doi:10.1016/s0065-230x(08)60634-x · Cited by 183
Self-citation
From Human Genetics and Genomics to Pharmacogenetics and Pharmacogenomics: Past Lessons, Future Directions
Nebert, D. W., Zhang, G., & Vesell, E. S. (2008) · Drug Metabolism Reviews · doi:10.1080/03602530801952864 · Cited by 181
Self-citation
The Ah locus: Correlation of intranuclear appearance of inducer-receptor complex with induction of cytochrome P1-450 mRNA
Tukey, R. H., Hannah, R. R., Negishi, M., Nebert, D. W., & Eisen, H. J. (1982) · Cell · doi:10.1016/0092-8674(82)90427-5 · Cited by 180
Self-citation
Nuclear uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice. Role of the hepatic cytosol receptor protein.
Greenlee, W. F., & Poland, A. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83589-5 · Cited by 174
Self-citation
Microsomal epoxide hydrolase properties, regulation and function
Seidegård, J., & DePierre, J. W. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(83)90014-8 · Cited by 166
Ontogenetic expression of polycyclic aromatic compound-inducible monooxygenase activities and forms of cytochrome P-450 in rabbit. Evidence for temporal control and organ specificity of two genetic regulatory systems.
Atlas, S. A., Boobis, A. R., Felton, J. S., Thorgeirsson, S. S., & Nebert, D. W. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40218-3 · Cited by 164
Self-citation
Regulatory gene product of the Ah locus. Characterization of receptor mutants among mouse hepatoma clones.
Legraverend, C., Hannah, R. R., Eisen, H. J., Owens, I. S., Nebert, D. W., & Hankinson, O. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)65155-9 · Cited by 157
Self-citation
Separation, purification, and properties of multiple forms of cytochrome P-450 from the liver microsomes of phenobarbital-treated mice.
Huang, M., West, S. B., & Lu, A. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33253-2 · Cited by 156
Genetic regulation of UDP-glucuronosyltransferase induction by polycyclic aromatic compounds in mice. Co-segregation with aryl hydrocarbon (benzo(alpha)pyrene) hydroxylase induction.
Owens, I. S. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40437-6 · Cited by 154
The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model
Avilla, M. N., Malecki, K. M. C., Hahn, M. E., Wilson, R. H., & Bradfield, C. A. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00476 · Cited by 148
Differential induction of cytosolic eposide hydrolase, microsomal epoxide hydrolase, and glutathione S-transferase activities
Hammock, B. D., & Ota, K. (1983) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(83)90342-3 · Cited by 133
Mechanisms of Ligand-Induced Aryl Hydrocarbon Receptor-Mediated Biochemical and Toxic Responses
Wilson, C., & Safe, S. H. (1998) · Toxicologic Pathology · doi:10.1177/019262339802600510 · Cited by 132
Inflammatory Signaling and Aryl Hydrocarbon Receptor Mediate Synergistic Induction of Interleukin 6 in MCF-7 Cells
Hollingshead, B. D., Beischlag, T. V., DiNatale, B. C., Ramadoss, P., & Perdew, G. H. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6168 · Cited by 123
Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: Effects on enzyme induction and immunotoxicity
Bannister, R. M., Davis, D., Zacharewski, T. R., Tizard, I. R., & Safe, S. (1987) · Toxicology · doi:10.1016/0300-483x(87)90135-1 · Cited by 120
Polychlorinated biphenyl immunotoxicity: Dependence on isomer planarity and the Ah gene complex
Silkworth, J. B., & Grabstein, E. M. (1982) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(82)90368-4 · Cited by 114
Developmental onset of mixed-function oxidase activity in preimplantation mouse embryos.
Filler, R., & Lew, K. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.6991 · Cited by 111
Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse.
Kumaki, K., Jensen, N. M., Shire, J. G. M., & Nebert, D. W. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32810-7 · Cited by 108
Self-citation
Cellular and Molecular Biology of Aryl Hydrocarbon (Ah) Receptor — Mediated Gene Expression
Safe, S. H., & Krishnan, V. (1995) · Archives of toxicology. Supplement · doi:10.1007/978-3-642-79451-3_8 · Cited by 107
Involvement of Glucocorticoids in the Development of the Secondary Palate
Salomon, D., & Pratt, R. M. (1979) · Differentiation · doi:10.1111/j.1432-0436.1979.tb01577.x · Cited by 101
CYP1A in TCDD Toxicity and in Physiology–with Particular Reference to CYP Dependent Arachidonic Acid Metabolism and other Endogenous Substrates
Rifkind, A. B. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600570107 · Cited by 97
The role of AhR in transcriptional regulation of immune cell development and function
Trikha, P., & Lee, D. A. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.188335 · Cited by 96
The CAT-Tox (L) Assay: A Sensitive and Specific Measure of Stress-Induced Transcription in Transformed Human Liver Cells
Todd, M. (1995) · Fundamental and Applied Toxicology · doi:10.1006/faat.1995.1153 · Cited by 98
[24] Genetic differences in microsomal electron transport: The Ah Locus
Nebert, D. W. (1978) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(78)52026-0 · Cited by 97
Self-citation
Immunosuppression by polycyclic aromatic hydrocarbons: A structure-activity relationship in B6C3F1 and DBA/2 mice
White, K. L., Lysy, H. H., & Holsapple, M. P. (1985) · Immunopharmacology · doi:10.1016/0162-3109(85)90011-6 · Cited by 96
Aryl hydrocarbon receptor response to indigoids in vitro and in vivo
Guengerich, F. P., Martin, M. V., McCormick, W. A., Nguyen, L. P., Glover, E. A., & Bradfield, C. A. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.01.002 · Cited by 99
Cytosolic receptor for aryl hydrocarbon hydroxylase induction by polycyclic aromatic compounds. Evidence for structural and regulatory variants among established cell cultured lines.
Guenthner, T. M., & Nebert, D. W. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38335-7 · Cited by 95
Self-citation
Determination of cytochrome P-448 activity in biological tissues
Phillipson, C. E., Godden, P. M. M., Lum, P. Y., Ioannides, C., & Parke, D. V. W. (1984) · Biochemical Journal · doi:10.1042/bj2210081 · Cited by 95
Long-Term Hazards of Polychlorinated Dibenzodioxins and Polychlorinated Dibenzofurans
Huff, J. E., Moore, J. A., Saracci, R., & Tomatis, L. (1980) · Environmental Health Perspectives · doi:10.1289/ehp.8036221 · Cited by 94
Divergence of metabolic activation systems for short-term mutagenesis assays
Selkirk, J. K. (1977) · Nature · doi:10.1038/270604a0 · Cited by 94
Hydroxylated Benzo[a]pyrene Metabolites Are Responsible for in Vitro Estrogen Receptor-Mediated Gene Expression Induced by Benzo[a]pyrene, but Do Not Elicit Uterotrophic Effects in Vivo
Fertuck, K. C. (2001) · Toxicological Sciences · doi:10.1093/toxsci/59.2.231 · Cited by 93
Regulatory gene product of the Ah complex. Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene binding to several moieties in mouse liver cytosol.
Hannah, R. R., Nebert, D. W., & Eisen, H. J. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69475-5 · Cited by 90
Self-citation
AHR2 Mutant Reveals Functional Diversity of Aryl Hydrocarbon Receptors in Zebrafish
Goodale, B. C., La Du, J. K., Bisson, W. H., Janszen, D. B., Waters, K. M., & Tanguay, R. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029346 · Cited by 89
Aryl hydrocarbon hydroxylase induction and its relationship to the toxicity of halogenated aryl hydrocarbons
Parkinson, A., & Safe, S. H. (1981) · Toxicological & Environmental Chemistry Reviews · doi:10.1080/02772248109356957 · Cited by 89
Comparative induction of aryl hydrocarbon hydroxylase activity in vitro by analogues of dibenzo-p-dioxin
Bradlaw, J. A., Garthoff, L. H., Hurley, N. E., & Firestone, D. (1980) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(80)80011-3 · Cited by 88
Characteristics of benzo(a)pyrene metabolism and cytochrome P-450 heterogeneity in rat liver nuclear envelope and comparison to microsomal membrane.
Fahl, W. E., Jefcoate, C. R. E., & Kasper, C. B. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40809-x · Cited by 87
Effects of structure on binding to the 2,3,7,8-TCDD receptor protein and AHH induction--halogenated biphenyls.
Safe, S. H., Bandiera, S. M., Sawyer, T. W., Zmudzka, B., Mason, G., Romkes, M., Denommé, M. A., Sparling, J., Okey, A. B., & Fujita, T. (1985) · Environmental Health Perspectives · doi:10.1289/ehp.856121 · Cited by 86
Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450.
Felton, J. S., & Nebert, D. W. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40998-8 · Cited by 83
Self-citation
Species differences in the substrate specificity of hepatic cytochrome P-448 From polycyclic hydrocarbon-treated animals
Thorgeirsson, S. S., Atlas, S. A., Boobis, A. R., & Felton, J. S. (1979) · Biochemical Pharmacology · doi:10.1016/0006-2952(79)90507-0 · Cited by 82
Drug metabolism in man and its relationship to that in three rodent species: Monooxygenase, epoxide hydrolase, and glutathione S-transferase activities in subcellular fractions of lung and liver
Lorenz, J., Glatt, H. R., Fleischmann, R., Ferlinz, R., & Oesch, F. (1984) · Biochemical Medicine · doi:10.1016/0006-2944(84)90007-3 · Cited by 79
Characteristics of microsomal enzyme controls in primary cultures of rat hepatocytes
Fahl, W. E., Michalopoulos, G. K., Sattler, G. L., Jefcoate, C. R. E., & Pitot, H. C. (1979) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(79)90071-7 · Cited by 77
Physiological implications of estrogen receptor modulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin
Umbreit, T. H., & Gallo, M. A. (1988) · Toxicology Letters · doi:10.1016/0378-4274(88)90097-5 · Cited by 74
Genetically mediated induction of drug‐metabolizing enzymes associated with congenital defects in the mouse
Lambert, G. H., & Nebert, D. W. (1977) · Teratology · doi:10.1002/tera.1420160206 · Cited by 74
Self-citation
[46] Microsomal epoxide hydrolase
Guenthner, T. M., Bentley, P., & Oesch, F. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77048-4 · Cited by 72
Alterations in cell-mediated immune functions induced in mouse splenic lymphocytes by polycyclic aromatic hydrocarbons.
Wojdani, A., & Alfred, L. J. (1984) · PubMed · Cited by 71
Effects of harman and norharman on the mutagenicity and binding to DNA of benzo[a]pyrene metabolites in vitro and on aryl hydrocarbon hydroxylase induction in cell culture
Levitt, R. C., Legraverend, C., Nebert, D. W., & Pelkonen, O. (1977) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(77)91129-9 · Cited by 69
Self-citation
Aryl hydrocarbon receptor (AhR) ligands as selective AhR modulators: Genomic studies
Safe, S. H., Han, H., Goldsby, J. S., Mohankumar, K., & Chapkin, R. S. (2018) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2018.11.005 · Cited by 70
The Ah Receptor: Controlling Factor in the Induction of Drug-Metabolizing Enzymes by Certain Chemical Carcinogens and Other Environmental Pollutants
Eisen, H. J., Hannah, R. R., Legraverend, C., Okey, A. B., & Nebert, D. W. (1983) · Biochemical Actions of Hormones · doi:10.1016/b978-0-12-452810-9.50012-7 · Cited by 65
Self-citation
Gonadal aryl hydrocarbon hydroxylase in rats and mice.
Mattison, D. R., & Thorgeirsson, S. S. (1978) · PubMed · Cited by 64
Effects of inducers and inhibitors on the metabolism of aflatoxin B, by rat and mouse
Gurtoo, H. L., & Dahms, R. P. (1979) · Biochemical Pharmacology · doi:10.1016/0006-2952(79)90084-4 · Cited by 63
Specificity of mouse liver cytosolic epoxide hydrolase for K-region epoxides derived from polycyclic aromatic hydrocarbons
Oesch, F., & Golan, M. D. (1980) · Cancer Letters · doi:10.1016/0304-3835(80)90083-x · Cited by 59
Enzymes of mercapturate synthesis and other drug-metabolizing reactions-specific localization in the eye
Das, N. D., & Shichi, H. (1981) · Experimental Eye Research · doi:10.1016/s0014-4835(81)80127-3 · Cited by 57
Genetic association of increases in naphthalene, acetanilide, and biphenyl hydroxylations with inducible aryl hydrocarbon hydroxylase in mice
Atlas, S. A., & Nebert, D. W. (1976) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(76)90537-3 · Cited by 57
Self-citation
Elevation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) polychlorinated biphenyls
Denommé, M. A., Leece, B., Li, A., Towner, R. A., & Safe, S. H. (1986) · Biochemical Pharmacology · doi:10.1016/0006-2952(86)90526-5 · Cited by 56
Separation of acetanilide and its hydroxylated metabolites and quantitative determination of “acetanilide 4-hydroxylase activity” by high-pressure liquid chromatography
Guenthner, T. M., Negishi, M., & Nebert, D. W. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90573-6 · Cited by 52
Self-citation
Xenobiotic and steroid-metabolizing monooxygenases catalysed by cytochrome P450 and glutathione S-transferase conjugations in the human placenta and their relationships to maternal cigarette smoking
Pasanen, M., & Pelkonen, O. (1990) · Placenta · doi:10.1016/s0143-4004(05)80445-x · Cited by 50
Birth defects and aplastic anemia: differences in polycyclic hydrocarbon toxicity associated with the Ah locus
Nebert, D. W., Levitt, R. C., Jensen, N. M., Lambert, G. H., & Felton, J. S. (1977) · Archives of Toxicology · doi:10.1007/bf00343280 · Cited by 50
Self-citation
Distribution of aryl hydrocarbon hydroxylase inducibility in cultured human lymphocytes.
Paigen, B. J., Minowada, J., Gurtoo, H. L., Paigen, K., Parker, N. B., Ward, E., Hayner, N. T., Bross, I. D. J., Bock, F. G., & Vincent, R. G. (1977) · PubMed · Cited by 50
Covalent binding in vitro of polychlorinated biphenyls to microsomal macromolecules
Tsutomu, S., & Sato, R. (1978) · Biochemical Pharmacology · doi:10.1016/0006-2952(78)90399-4 · Cited by 48
Polychlorinated dibenzofurans as 2,3,7,8-tcdd antagonists: In vitro inhibition of monooxygenase enzyme induction
Keys, B., Piskorska-Pliszczynska, J., & Safe, S. H. (1986) · Toxicology Letters · doi:10.1016/0378-4274(86)90009-3 · Cited by 48
Genetic differences in the induction of monooxygenase activities by polycyclic aromatic compounds
Nebert, D. W. (1979) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(79)90052-4 · Cited by 47
Self-citation
Origins of Individual Variability in P4501A Induction
Ma, Q., & Lu, A. Y. H. (2003) · Chemical Research in Toxicology · doi:10.1021/tx0200919 · Cited by 46
Hepatic cytochrome P-450-dependent monooxygenase systems of the trout, frog and snake—III. Induction
Schwen, R. J., & Mannering, G. J. (1982) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(82)90407-2 · Cited by 46
The biochemical and genetic characteristics of murine ovarian aryl hydrocarbon (Benzo[a]pyrene) hydroxylase activity and its relationship to primordial oocyte destruction by polycyclic aromatic hydrocarbons
Mattison, D. R., & Nightingale, M. R. (1980) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(80)90074-5 · Cited by 45
Inhibition of Chemical Carcinogenesis
DiGiovanni, J. (1990) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-74778-6_7 · Cited by 45
Differential induction of murine Ah locus-associated monooxygenase activities in rabbit liver and kidney
Atlas, S. A., Thorgeirsson, S. S., Boobis, A. R., Kumaki, K., & Nebert, D. W. (1975) · Biochemical Pharmacology · doi:10.1016/0006-2952(75)90114-8 · Cited by 44
Self-citation
Epoxide hydratase and benzo(A)pyrene monooxygenase activities in liver, kidney and lung after treatment of rats with epoxides of widely varying structures
Schmassmann, H., Sparrow, A. J., Platt, K. L., & Oesch, F. (1978) · Biochemical Pharmacology · doi:10.1016/0006-2952(78)90083-7 · Cited by 44
Effects of Structure on Binding to the 2,3,7,8-TCDD Receptor Protein and AHH Induction. Halogenated Biphenyls
Safe, S. H., Bandiera, S. M., Sawyer, T. Y., Zmudzka, B., MASON, G. G. F., Romkes, M., Denommé, M. A., Sparling, J., Okey, A. B., & Fujita, T. (1985) · Environmental Health Perspectives · doi:10.2307/3430059 · Cited by 43
The Ah Locus: Genetic Regulation of the Enzymes which Metabolize Polycyclic Hydrocarbons and the Risk for Cancer
Nebert, D. W., Atlas, S. A., Guenthner, T. M., & Kouri, R. E. (1978) · Elsevier eBooks · doi:10.1016/b978-0-12-279202-1.50028-2 · Cited by 43
Self-citation
Ah Locus: Genetic Differences in Susceptibility to Cataracts Induced by Acetaminophen
Shichi, H., Gaasterland, D., Jensen, N. M., & Nebert, D. W. (1978) · Science · doi:10.1126/science.644313 · Cited by 42
Self-citation
Population distribution of placental benzo(α)pyrene metabolism in smokers
Gurtoo, H. L., Williams, C. J., Gottlieb, K., Mulhern, A. I., Caballes, L., Vaught, J. B., Marinello, A. J., & Bansal, S. K. (1983) · International Journal of Cancer · doi:10.1002/ijc.2910310106 · Cited by 42
Species and organ specificity of the trans-stilbene oxide induced effects on epoxide hydratase and benzo(a)pyrene monooxygenase activity in rodents
Oesch, F., & Schmassmann, H. (1979) · Biochemical Pharmacology · doi:10.1016/0006-2952(79)90498-2 · Cited by 42
Glutathione in the developing mouse liver—I
Lambert, G. H., & Thorgeirsson, S. S. (1976) · Biochemical Pharmacology · doi:10.1016/0006-2952(76)90415-9 · Cited by 41
Genetically regulated aryl hydrocarbon hydroxylase induction in the eye: Possible significance of the drug-metabolizing enzyme system for the retinal pigmented epithelium-choroid
Shichi, H., Atlas, S. A., & Nebert, D. W. (1975) · Experimental Eye Research · doi:10.1016/0014-4835(75)90038-x · Cited by 41
Self-citation
SU5416, a VEGF Receptor Inhibitor and Ligand of the AHR, Represents a New Alternative for Immunomodulation
Mezrich, J. D., Nguyen, L. P., Kennedy, G., Nukaya, M., Fechner, J. H., Zhang, X., Xing, Y., & Bradfield, C. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044547 · Cited by 40
Amine oxidase in mice—sex differences and developmental aspects
Wirth, P. J., & Thorgeirsson, S. S. (1978) · Biochemical Pharmacology · doi:10.1016/0006-2952(78)90401-x · Cited by 40
The induction of hepatic cytochrome P-450 in C57 BL/10 and DBA/2 mice by isosafrole and piperonyl butoxide. A comparative study with other inducing agents
Fennell, T. R., Sweatman, B. C., & Bridges, J. W. (1980) · Chemico-Biological Interactions · doi:10.1016/0009-2797(80)90005-8 · Cited by 40
Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases
Pellinen, P., Stenb�ck, F., Rautio, A., Pelkonen, O., Lang, M. A., & Pasanen, M. (1993) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00171345 · Cited by 39
Mitogen Induced Proliferative Responses of Lymphocytes from Spot (Leiostomus Xanthurus) Exposed to Polycyclic Aromatic Hydrocarbon Contaminated Environments
Faisal, M., Marzouk, M. S., Smith, C. L., & Huggett, R. J. (1991) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923979109019707 · Cited by 39
INDUCIBLE MONOOXYGENASE ACTIVITIES AND 3-METHYLCHOLANTHRENE-INITIATED TUMORIGENESIS IN MOUSE RECOMBINANT INBRED SUBLINES
Atlas, S. A., Taylor, B. A., Diwan, B. A., & Nebert, D. W. (1976) · Genetics · doi:10.1093/genetics/83.3.537 · Cited by 39
Self-citation
Genetics and cancer
Ponder, B. A. J. (1980) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(80)90007-4 · Cited by 39
Studies on the hepatic microsomal metabolism of [14C]phenanthrene
Chaturapit, S., & Holder, G. M. (1978) · Biochemical Pharmacology · doi:10.1016/0006-2952(78)90034-5 · Cited by 38
Association and dissociation of the Ah locus with the metabolism of aflatoxin B1 by mouse liver. Co-segregation of aflatoxin B1 hydroxylase induction with aryl hydrocarbon (benzo(a)pyrene) hydroxylase induction.
Gurtoo, H. L., Dahms, R. P., Kanter, P. M., & Vaught, J. B. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34783-x · Cited by 38
Human Placental Xenobiotic and Steroid Biotransformations Catalyzed By Cytochrome P450, Epoxide Hydrolase, and Glutathione S-Transferase Activities and Their Relationships to Maternal Cigarette Smoking
Pasanew, M., & Pelkonen, O. (1989) · Drug Metabolism Reviews · doi:10.3109/03602538909030305 · Cited by 36
A new assay for glutathione S-transferase using [3H]-benzo(a)pyrene 4,5-oxide as substrate
CANTFORT, J. V., Manil, L., Gielen, J., Glatt, H. R., & Oesch, F. (1979) · Biochemical Pharmacology · doi:10.1016/0006-2952(79)90235-1 · Cited by 36
Enzyme Induction
GELEHRTER, T. D. (1976) · New England Journal of Medicine · doi:10.1056/nejm197603112941105 · Cited by 34

Authors: Nebert, D. W., Robinson, J. R., Niwa, A., Kumari, K., & Poland, A. P.
Affiliations: National Institutes of Health (US)
University of Rochester Medicine (US)
ORCID: Robinson, Joseph R.
Venue: Journal of Cellular Physiology
Publisher: Wiley
Published: 1975-04
Volume: 85
Issue: S1
Pages: 393-414
ISSN: 0021-9541 (ISSN-L)
1097-4652
DOI: 10.1002/jcp.1040850407
OpenAlex: W1982386536
Cited by: 247
References: 56
Citations by year: 2025: 1 · 2023: 4 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2013: 1 · 2012: 2
FWCI: 5.75
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 14763 d)
Locations: Journal of Cellular Physiology (publishedVersion)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
Keywords: aryl hydrocarbon hydroxylase, mixed function oxidase, benzo[a]pyrene, 2,3,7,8-tetrachlorodibenzo-p-dioxin, genetic polymorphism, inbred mouse strains, hepatic drug metabolism, beta-naphthoflavone, 3-methylcholanthrene
MeSH terms: Polychlorinated Dibenzodioxins, Animals, Aryl Hydrocarbon Hydroxylases, Benzopyrenes, Crosses, Genetic, Cytochrome P-450 Enzyme System, Enzyme Induction, Enzyme Inhibitors, Genes, Genes, Regulator, Hydroxylation, Liver, Mice, Inbred Strains, Microsomes, Liver, Mitomycins, Models, Biological, Multienzyme Complexes, Oxygenases, Receptors, Drug, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks