Cited by 247Pharmacogenetics and Drug MetabolismToxic Organic Pollutants ImpactMetal-Catalyzed Oxygenation Mechanisms

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Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse

Nebert, Daniel W., Robinson, Joseph R., Niwa, Akira, Kumari, Kenji, Poland, Alan P.·1975·Journal of Cellular Physiology

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Abstract

Monooxygenases require NADPH and molecular oxygen during the metabolism of numerous endogenous hydrophobic substrates and carcinogenic and toxic exogenous chemicals. The complexity of these membrane-bound multicomponent drug-metabolizing enzyme systems is reviewed. What "aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity" actually represents is reviewed and discussed. At least two forms of the hydroxylase activity exist and we suggest that they are associated with different molecular species of membrane-bound CO-binding hemoprotein (i.e., they are associated with different enzyme active-sties). At least two, and probably more than two, nonlinked loci are responsible for the genetic expression of new cytochrome P1450 formation and aryl hydrocarbon hydroxylase induction--and the stimulation of 10 other monooxygenase "activities"--in the mouse treated with certain aromatic hydrocarbons. The individual variability of hydroxylase activity in an inbred and in a random-bred strain of micr is illustrated. The basal hydroxylase activity appears to be inherited differently from the aromatic hydrocarbon-inducible hydroxylase activity. The potent inducer 2,3,7,8-tetrachlorodibenzo-p-dioxin can stimulate increases in these hepatic monooxygenase activities and p1450 formation in so-called "nonresponsive" mice, whereas inducers such as beta-naphthoflavone and 3-methylcholanthrene cannot. Thus, the genetically "nonresponsive" micr apparently possess the structural and regulatory genes ne…

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PHARMACOLOGICAL IMPLICATIONS OF MICROSOMAL ENZYME INDUCTION
Conney, A. H. (1967) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07146-7 · Cited by 2,942
Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture
Nebert, D. W., & Gelboin, H. V. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94484-4 · Cited by 1,682
Self-citation
Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide
Sims, P. H., Grover, P. L., Swaisland, A. J., Pal, K., & Hewer, A. J. (1974) · Nature · doi:10.1038/252326a0 · Cited by 1,134
Arene Oxides: A New Aspect of Drug Metabolism
JERINA, D. M., & Daly, J. W. (1974) · Science · doi:10.1126/science.185.4151.573 · Cited by 1,039
Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds
Oesch, F. (1973) · Xenobiotica · doi:10.3109/00498257309151525 · Cited by 824
UPTAKE OF RADIOACTIVE ALANINE IN VITRO INTO THE PROTEINS OF RAT LIVER FRACTIONS
Siekevitz, P. (1952) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55763-x · Cited by 686
Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds
Daly, J. W., JERINA, D. M., & Witkop, B. (1972) · Cellular and Molecular Life Sciences · doi:10.1007/bf01946135 · Cited by 599
Aryl Hydrocarbon Hydroxylase Inducibility and Bronchogenic Carcinoma
Kellermann, G. H., Shaw, C. R., & Luyten-Kellerman, M. (1973) · New England Journal of Medicine · doi:10.1056/nejm197311012891802 · Cited by 592
Benzpyrene hydroxylase activity in the gastrointestinal tract.
Lw, W., Leong, J. L., & STRAND, P. J. (1962) · PubMed · Cited by 331
Genetic Expression of Aryl Hydrocarbon Hydroxylase Activity
Poland, A., Glover, E. A., Robinson, J. R., & Nebert, D. W. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)79769-3 · Cited by 329
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Research works printed but not linked: 19

Conney, 1967, Pharmacol. Rev., 19, 317
and 1975 Properties of purified cytochrome P-450 and NADPH-cytochrome P-450 reductase from rabbit liver microsomes. Adv. Exp. Med. Biol., in press.
1971 Probit Analysis. Cambridge University Press, London, 333 pp.
Goujon, 1972, Mol. Pharmacol., 8, 667
Kellermann, 1973a, Amer. J. Human Genet., 25, 327
Mason, 1975, Adv. Enzymol., 19, 79
Nebert, 1972, Fed. Proc., 31, 1315
Nebert, 1972a, Mol. Pharmacol., 8, 651
Nebert, 1973b, Genetic specificity resides in the fraction containing cytochromes P448 and P450. J. Biol. Chem., 248, 7631
Oesch, 1973, Mol. Pharmacol., 9, 692
Poland, 1973, Mol. Pharmacol., 9, 736
Poland, 1974, Mol. Pharmacol., 10, 349
Poppers, 1974, Pharmacologist, 16, 262
Rasmussen, 1974, Cancer Res., 34, 2290
and 1975 Pharmacogenetic aspects of drug toxicity and teratogenesis in the newborn. In: Perinatal Pharmacology. F. Sereni, S. Garattini and P. L. Morselli, eds., in press.
Robinson, 1974, Mol. Pharmacol., 10, 484
Staats, 1972, Cancer Res., 32, 1609
Thorgeirsson, 1974, Pharmacologist, 16, 277
Wattenberg, 1962, Cancer Res., 22, 1120

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Authors: Nebert, D. W., Robinson, J. R., Niwa, A., Kumari, K., & Poland, A. P.
Affiliations: National Institutes of Health (US)
University of Rochester Medicine (US)
ORCID: Robinson, Joseph R.
Venue: Journal of Cellular Physiology
Publisher: Wiley
Published: 1975-04
Volume: 85
Issue: S1
Pages: 393-414
ISSN: 0021-9541 (ISSN-L)
1097-4652
DOI: 10.1002/jcp.1040850407
OpenAlex: W1982386536
Cited by: 247
References: 56
Citations by year: 2025: 1 · 2023: 4 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2013: 1 · 2012: 2
FWCI: 5.75
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 14763 d)
Locations: Journal of Cellular Physiology (publishedVersion)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
Keywords: aryl hydrocarbon hydroxylase, mixed function oxidase, benzo[a]pyrene, 2,3,7,8-tetrachlorodibenzo-p-dioxin, genetic polymorphism, inbred mouse strains, hepatic drug metabolism, beta-naphthoflavone, 3-methylcholanthrene
MeSH terms: Polychlorinated Dibenzodioxins, Animals, Aryl Hydrocarbon Hydroxylases, Benzopyrenes, Crosses, Genetic, Cytochrome P-450 Enzyme System, Enzyme Induction, Enzyme Inhibitors, Genes, Genes, Regulator, Hydroxylation, Liver, Mice, Inbred Strains, Microsomes, Liver, Mitomycins, Models, Biological, Multienzyme Complexes, Oxygenases, Receptors, Drug, Mice

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Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse

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