The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Pigment epithelium‐derived factor inhibits retinal and choroidal neovascularization
Abstract
In this study, we investigated whether overexpression of pigment epithelium‐derived factor (PEDF) by gene transfer can inhibit neovascularization by testing its effect in three different models of ocular neovascularization. Intravitreous injection of an adenoviral vector encoding PEDF resulted in expression of PEDF mRNA in the eye measured by RT‐PCR and increased immunohistochemical staining for PEDF protein throughout the retina. In mice with laser‐induced rupture of Bruch's membrane, choroidal neovascularization was significantly reduced after intravitreous injection of PEDF vector compared to injection of null vector or no injection. Subretinal injection of the PEDF vector resulted in prominent staining for PEDF in retinal pigmented epithelial cells and strong inhibition of choroidal neovascularization. In two models of retinal neovascularization (transgenic mice with increased expression of vascular endothelial growth factor (VEGF) in photoreceptors and mice with oxygen‐induced ischemic retinopathy), intravitreous injection of null vector resulted in decreased neovascularization compared to no injection, but intravitreous injection of PEDF vector resulted in further inhibition of neovascularization that was statistically significant. These data suggest that sustained increased intraocular expression of PEDF by gene therapy might provide a promising approach for treatment of ocular neovascularization. © 2001 Wiley‐Liss, Inc.
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Cites
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486
Cited by
Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies
Ambati, J., Ambati, B. K., Yoo, S. H., Ianchulev, S., & Adamis, A. P. (2003) · Survey of Ophthalmology · doi:10.1016/s0039-6257(03)00030-4 · Cited by 959
Animal models of choroidal and retinal neovascularization
Grossniklaus, H. E., Kang, S. J., & Berglin, L. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.05.003 · Cited by 350
Campochiaro, P. A., Nguyen, Q. D., Shah, S. M., Klein, M. L., Holz, E., Frank, R. N., Saperstein, D. A., Gupta, A., Stout, J. T., Macko, J., et al. (2006) · Human Gene Therapy · doi:10.1089/hum.2006.17.167 · Cited by 343
Self-citationSchmidt-Erfurth, U., Schlo¨tzer-Schrehard, U., Cursiefen, C., Michels, S., Beckendorf, A., & Naumann, G. O. H. (2003) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.02-1115 · Cited by 317
Tsutsumi, C., Sonoda, K.-H., Egashira, K., Qiao, H., Hisatomi, T., Nakao, S., Ishibashi, M., Charo, I. F., Sakamoto, T., Murata, T., et al. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0902436 · Cited by 277
Metadata
- Authors
- Mori, K., Duh, E., Gehlbach, P., Ando, A., Takahashi, K., Pearlman, J., Mori, K., Yang, H. S., Zack, D. J., Ettyreddy, D., Brough, D. E., Wei, L. L., & Campochiaro, P. A.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2001-06-11
- Volume
- 188
- Issue
- 2
- Pages
- 253-263
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2042523510
- Cited by
- 337
- References
- 2
- FWCI
- 25.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mori, K., Duh, E., Gehlbach, P., Ando, A., Takahashi, K., Pearlman, J., Mori, K., Yang, H. S., Zack, D. J., Ettyreddy, D., Brough, D. E., Wei, L. L., & Campochiaro, P. A. (2001). Pigment epithelium‐derived factor inhibits retinal and choroidal neovascularization. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.1114
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