The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Fibronectin, integrins, and growth control
Open accessAbstract
Cell proliferation is controlled not only by soluble mitogens but also by components of the extracellular matrix (ECM) such as fibronectin, to which cells adhere via the integrin family of transmembrane receptors. Input from both growth factor receptors and integrins is required to stimulate progression through the G1 phase of the cell cycle, via induction of G1 cyclins and suppression of inhibitors of the G1 cyclin‐dependent kinases. Extensive crosstalk takes place between integrin and growth factor receptor signaling pathways, and mitogenic signaling is weak and transient in the absence of integrin‐mediated cell adhesion. In normal untransformed cells, all of the important mitogenic signal transduction cascades, namely those downstream of the Ras and Rho family small GTPases and the phosphoinositide 3‐OH kinase‐PKB/Akt pathway, are regulated by integrin‐mediated cell adhesion. As a result, these cells are anchorage‐dependent for growth. In contrast, constitutive activity of each of these pathways has been reported in cancer cells, which not only reduces their mitogen dependence but also allows these cells to grow in an anchorage‐independent fashion. © 2001 Wiley‐Liss, Inc.
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Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
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“…both normal and transformed cells are growthinhibited on ®brillar collagen, but not on monomeric collagen, may be due to inef®cient binding or clustering of a2b1 on ®brillar collagen, resulting in growthinhibitory signaling by the unoccupied integrins (Koyama et al., 1996; Henriet et al., 2000).”
BackgroundFormation of actin stress fibers and focal adhesions enhanced by Rho-kinase
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Cited by
Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606
RAS oncogenes: weaving a tumorigenic web
Pylayeva-Gupta, Y., Grabocka, E., & Bar-Sagi, D. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3106 · Cited by 1,789
Sahai, E., & Marshall, C. J. (2002) · Nature Reviews Cancer · doi:10.1038/nrc725 · Cited by 1,261
Matricellular proteins: extracellular modulators of cell function
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Adhesion signaling – crosstalk between integrins, Src and Rho
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Self-citation
Metadata
- Authors
- Danen, E. H. J., & Yamada, K. M.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2001-08-22
- Volume
- 189
- Issue
- 1
- Pages
- 1-13
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2036908471
- Cited by
- 456
- References
- 11
- FWCI
- 17.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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