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Increased Resistance of Breast, Prostate, and Embryonic Carcinoma Cells against Herpes Simplex Virus in Three-Dimensional Cultures

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Organotypic Human Skin Cultures Incorporating Primary Melanocytes

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Development of three-dimensional (3D) spheroid culture system from rainbow trout kidney cell line (RTK) for in vitro production of fish viral pathogen

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Recent Advances in Graphene Oxide-Based on Organoid Culture as Disease Model and Cell Behavior – A Systematic Literature Review

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Identification and functional validation of therapeutic targets for malignant melanoma

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3D cancer tumor models for evaluating chemotherapeutic efficacy

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Hyaluronan-Based Hydrogels for 3D Modeling of Tumor Tissues

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CHD1 loss negatively influences metastasis-free survival in R0-resected prostate cancer patients and promotes spontaneous metastasis in vivo

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Inhibitor of DNA Binding 4 (ID4) Is Highly Expressed in Human Melanoma Tissues and May Function to Restrict Normal Differentiation of Melanoma Cells

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Bladder cancer: therapeutic challenges and role of 3D cell culture systems in the screening of novel cancer therapeutics

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Morphological and cytoskeletal alterations of nervous system tumor cells with different culturing methods

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3D multicellular models to study the regulation and roles of acid–base transporters in breast cancer

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Fluorescent multiplexing of 3D spheroids: Analysis of biomarkers using automated immunohistochemistry staining platform and multispectral imaging

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3D culture of fibroblasts and neuronal cells on microfabricated free-floating carriers

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Imaging cell spheroid clusters: An MRI protocol for non-invasive standardized characterization

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Preparation, Drug Treatment, and Immunohistological Analysis of Tri-Culture Spheroid 3D Melanoma-Like Models

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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

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Advances in cryostructures and their applications in biomedical and pharmaceutical products

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Bioengineered Cystinotic Kidney Tubules Recapitulate a Nephropathic Phenotype

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Increased Resistance of Vasculogenic Mimicry-Forming Uveal Melanoma Cells against Cytotoxic Agents in Three-Dimensional Cultures

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Concentration-Dependent Dual Effects of Ciprofloxacin on SB-590885-Resistant BRAFV600E A375 Melanoma Cells

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Three-dimensional bioprinted hepatorganoids in liver failure

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Spheroid-formation 3D engineering model assay for in vitro assessment and expansion of cancer cells

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Growth environment influences B16.F10 mouse melanoma cell response to gene electrotransfer

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Three-dimensional scaffolds: an in vitro strategy for the biomimetic modelling of in vivo tumour biology

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3D bioprinting strategies for recapitulation of hepatic structure and function in bioengineered liver: A state-of-the-art review

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Extrapolation of In Vitro Results to Predict Human Toxicity

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Lung tumor organoids migrate as cell clusters containing cancer stem cells under hypoxic condition

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Patient-derived melanoma models

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Alternative Culture Systems for Bovine Oocyte In Vitro Maturation: Liquid Marbles and Differentially Shaped 96-Well Plates

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Biodistribution and toxicity assessment of methoxyphenyl phosphonium carbosilane dendrimers in 2D and 3D cell cultures of human cancer cells and zebrafish embryos

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3D Cardiac Cell Culture on Nanofiber Bundle Substrates for the Investigation of Cell Morphology and Contraction

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A new approach to assess drug sensitivity in cells for novel drug discovery

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Materials and assay systems used for three‐dimensional cell culture

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Redox-responsive micellar-like nanoparticles can overcome intrinsic multi-drug resistance in tumour spheroids of triple negative breast cancer

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Engineering in vitro complex pathophysiologies for drug discovery purposes

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Identification of therapeutic sensitivities in a spheroid drug combination screen of Neurofibromatosis Type I associated High Grade Gliomas

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Three-Dimensional Spheroid Cell Culture Model for Target Identification Utilizing High-Throughput RNAi Screens

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Culture of Tumorigenic Cells on Protein Fibers Reveals Metastatic Cell Behaviors

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Assessment of Genotoxic Effects by Constructing a 3D Cellular System with Highly Sensitive Mutagenic Human–Hamster Hybrid Cells

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Enhanced growth and myogenic differentiation of spheroid-derived C2C12 cells

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Transcriptome-Wide Association Study Reveals New Molecular Interactions Associated with Melanoma Pathogenesis

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Bioimprinting: Bringing Together 2D and 3D in Dissecting Cancer Biology

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Epidermal growth factor and three‐dimensional scaffolds provide conducive environment for differentiation of mouse embryonic stem cells into oocyte‐like cells

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Cutting-edge technologies in neural regeneration

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Mimicking the immunosuppressive impact of fibroblasts in a 3D multicellular spheroid model

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Developmental Biology-Based 3D Bioprinting: An Off-the-Shelf Strategy to Induce Tissue Regeneration

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Recent advances in tumors-on-chips

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Colorectal cysts as a validating tool for CAR therapy

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Fabrication of pseudo three-dimensional PADC cell culture substrates for dosimetric studies

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Molecular basis for cytokine biomarkers of complex 3D microtissue physiology in vitro

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Human Microtumors Generated in 3D: Novel Tools for Integrated In Situ Studies of Cancer Immunotherapies

Hambach, L., Buser, A. S., Vermeij, M., Pouw, N. M. C., van der Kwast, T., & Goulmy, E. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3338-9_15 · Cited by 3

Cytokine profiling of MCF‐7 cell line 2D, progressive 3D, and 3D revert cultures

Subramaniyan, A., & Ravi, M. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26349 · Cited by 3

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Unraveling the complexity of glioblastoma microenvironment: A comparative study of 3D and 2D cultures in response to combination drug therapy

Rashidi, R., Hadjighassem, M., & Negahdari, B. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149783 · Cited by 2

Global Proteome Analysis of a Three-Dimensional Human Chondrocyte Cell Culture System Infected with Chikungunya Virus (CHIKV) Reveals Distinct Immune and Inflammatory Signatures

Hasan, A., Sharma, G., Majumder, N., Chaudhary, S., Mehta, D., Vaishya, R., Ghosh, S., & Sunil, S. (2025) · ACS Omega · doi:10.1021/acsomega.5c02832 · Cited by 2

An early-stage 3D fibroblast-featured tumor model mimics the gene expression of the naïve tumor microenvironment, including genes involved in cancer progression and drug resistance

Costabile, F., George, S. S., Facciabene, A., Filaci, G., & Mastrogiacomo, M. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1572315 · Cited by 2

The Influence of Human Astrocyte-Conditioned Media on Glioblastoma Multiforme Response to Temozolomide and Bay 11-7082

Pustchi, S. E., Waits, C. M. K., Avci, N. G., McGill, L. D., Akay, Y. M., & Akay, M. (2022) · IEEE Access · doi:10.1109/access.2022.3146887 · Cited by 2

3D cell subculturing pillar dish for pharmacogenetic analysis and high-throughput screening

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A robust, flow-based, microfluidic device for siRNA-mediated gene knockdown in glioblastoma spheroids

Hosni, I., Iles, A., Greenman, J., & Wade, M. (2023) · Innovation and Emerging Technologies · doi:10.1142/s2737599423400054 · Cited by 4

Advancing cancer therapeutics: Integrating scalable 3D cancer models, extracellular vesicles, and omics for enhanced therapy efficacy

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Human Organotypic Respiratory Models

Svensson, M., & Chen, P. (2018) · Current topics in microbiology and immunology · doi:10.1007/82_2018_91 · Cited by 2

Stellenwert der Zellkulturmodelle in kutaner Tumorbiologie

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Current Scenario of Regenerative Medicine: Role of Cell, Scaffold and Growth Factor

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Overview of Primary Cell Culture Models in Preclinical Research of Prostate and Bladder Cancer

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The Transmission and Toxicity of Polymer-Bound Doxorubicin-Containing Exosomes Derived from Human Adenocarcinoma Celxdls

Gunár, K., Kotrchová, L., Filipová, M., Krunclová, T., Dydowiczová, A., Pola, R., Randárová, E., Etrych, T., & Janoušková, O. (2022) · Nanomedicine · doi:10.2217/nnm-2022-0081 · Cited by 3

Rounding Up Apoptosis Resistance Targets in Lung Cancer

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Unraveling the mechanism of the anticancer potential of emodin using 2D and spheroid models of A549 cells

Sangseekew, W., Ornnork, N., Sornprachum, T., Sirirak, J., Lirdprapamongkol, K., Boonsombat, J., Svasti, J., & Keeratichamroen, S. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150908 · Cited by 1

Three-Dimensional Hydrogel Culture Reveals Novel Differentiation Potential of Human Bone Marrow-Derived Stem Cells

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TSG6 affects anti cancer drug resistance and angiogenesis in 3D spheroid model of canine mammary gland tumor cells

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Engineering biocompatible polylactic acid (PLA) microcarriers for enhanced 3D cell culture

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Bioengineered In Vitro 3D Cancer Models: A New Paradigm in Ethical and Predictive Oncology Research Toward Successful Pre‐Clinical Drug Screening

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SURVEY AND SUMMARY Single-cell RNA-seq: advances and future challenges

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Epithelial-To-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma: Fiction or Fact?

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Popular three-dimensional models: Advantages for cancer, Alzheimer’s and cardiovascular diseases

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3D culture systems as models for solid tumors and cancer metabolism

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Caracterização funcional das isoformas de splicing do gene ADAM23

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Stellenwert der Zellkulturmodelle in kutaner Tumorbiologie

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Culture of Melanoma Cells in 3-Dimensional Architectures Results in Impaired Immunorecognition by Cytotoxic T Lymphocytes Specific for Melan-A/MART-1 Tumor-Associated Antigen

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