Cited by 1,803Cancer Cells and MetastasisMathematical Biology Tumor GrowthCancer, Hypoxia, and Metabolism

Cell and environment interactions in tumor microregions: the multicell spheroid model.

Sutherland, Robert M.·1988·Science

Abstract

Abnormal vascularization of malignant tumors is associated with the development of microregions of heterogeneous cells and environments. Experimental models such as multicell spheroids and a variety of new techniques are being used to determine the characteristics of these microregions and to study the interactions of the cells and microenvironments. The special cellular microecology of tumors influences responsiveness to therapeutic agents and has implications for future directions in cancer research.

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Crossref · 10.1126/science.2451290

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130 of 130 references verified0 citation errors · 0 not checkable

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Authors
Sutherland, R. M.
Affiliations
University of Rochester Medicine (US)
Corresponding author
Sutherland, Robert M.
Venue
Science
Published
1988-04-08
Volume
240
Issue
4849
Pages
177-184
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2041585886
Cited by
1,803
References
130
Citations by year
2026: 28 · 2025: 30 · 2024: 40 · 2023: 32 · 2022: 47 · 2021: 54 · 2020: 54 · 2019: 68 · 2018: 54 · 2017: 70 · 2016: 72 · 2015: 64 · 2014: 64 · 2013: 70 · 2012: 49
FWCI
24.52
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (CA1 1198, CA 11051, CA20329)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords
multicell spheroids, tumor microenvironment, tumor heterogeneity, tumor vascularization, cell-microenvironment interactions, cancer therapy response
MeSH terms
Antineoplastic Agents, Cell Adhesion, Cell Differentiation, Cell Division, Humans, Hydrogen-Ion Concentration, Immunity, Neoplasms, Experimental, Neovascularization, Pathologic, Radiotherapy Dosage, Culture Techniques

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