The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Regulation of stemness and stem cell niche of mesenchymal stem cells: Implications in tumorigenesis and metastasis
Abstract
Human mesenchymal stem cells (MSCs) derived from adult tissues have been considered a candidate cell type for cell‐based tissue engineering and regenerative medicine. These multipotent cells have the ability to differentiate along several mesenchymal lineages and possibly along non‐mesenchymal lineages. MSCs possess considerable immunosuppressive properties that can influence the surrounding tissue positively during regeneration, but perhaps negatively towards the pathogenesis of cancer and metastasis. The balance between the naïve stem state and differentiation is highly dependent on the stem cell niche. Identification of stem cell niche components has helped to elucidate the mechanisms of stem cell maintenance and differentiation. Ultimately, the fate of stem cells is dictated by their microenvironment. In this review, we describe the identification and characterization of bone marrow‐derived MSCs, the properties of the bone marrow stem cell niche, and the possibility and likelihood of MSC involvement in cancer progression and metastasis. J. Cell. Physiol. 222: 268–277, 2010. © 2009 Wiley‐Liss, Inc.
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“Time-lapse video microscopy used in conjunction to assay for single-cell clonal expansion has provided the most convincing evidence for stem cell self-renewal (Cao et al., 2004; Dykstra et al., 2006; Lutolf et al., 2009).”
MethodA perivascular origin for mesenchymal stem cells in multiple human organs
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BackgroundLaminin–a glycoprotein from basement membranes
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Cited by
Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche
Mohyeldin, A., Garzón-Muvdi, T., & Quiñones-Hinojosa, A. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.07.007 · Cited by 1,535
Department of Mechanical and Biomedical Engineering, N. U. O. I. G., Birmingham, E., Niebur, G., McHugh, P., Shaw, G., Barry, F., & McNamara, L. (2012) · European Cells and Materials · doi:10.22203/ecm.v023a02 · Cited by 490
Lin, H., Sohn, J., Shen, H., Langhans, M. T., & Tuan, R. S. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.026 · Cited by 445
Self-citation(1926) · The American Journal of Surgery · doi:10.1016/s0002-9610(26)90068-8 · Cited by 293
Current and emerging concepts in tumour metastasis
Coghlin, C., & Murray, G. I. (2010) · The Journal of Pathology · doi:10.1002/path.2727 · Cited by 257
Metadata
- Authors
- Kuhn, N. Z., & Tuan, R. S.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2009-10-21
- Volume
- 222
- Issue
- 2
- Pages
- 268-277
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2131717731
- Cited by
- 270
- References
- 17
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- closed
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