Ribosome biogenesis: Emerging evidence for a central role in the regulation of skeletal muscle mass

The “Ribosome biogenesis and translation capacity” section (page not provided) says ribosome quantity mainly determines translational capacity. It also says protein-synthesis rate depends on translational efficiency and other machinery, so it does not establish an absolute ceiling set by the ribosomal pool alone. (LLM, conf=0.85)

In “Regulation of ribosome biogenesis in response to high contractile activity” (page not provided), the paper says total RNA is predominantly rRNA and that an increase in total RNA indicates increased translational capacity. But its resistance-exercise discussion reports increased total RNA in rats, only a tendency toward an increase in humans, and says ribosome-biogenesis activation remains to be clearly elucidated. It does not establish that bulk total RNA accumulation definitively demonstrates expansion of the mature rRNA pool after exercise. (LLM, conf=0.88)

In “Ribosome biogenesis and translation capacity” (page unavailable), the paper explains that Pol I transcribes 47S pre-rRNA and that processing, modification, assembly and export are additional steps before mature ribosomes form. This supports the distinction between transcription and maturation, but the paper does not specifically address elevated 45S pre-rRNA abundance or show that such an elevation fails to produce mature functional subunits. (LLM, conf=0.82)

The sections on ribosome biogenesis and high contractile activity (page unavailable) describe coordinated roles for Pol I and Pol II and report increased expression of several ribosomal-protein genes in a muscle-hypertrophy model. They do not report whole-muscle RNA-seq mapping exercise adaptation or show that snoRNAs and ribosomal proteins are dynamically synchronized with Pol I activity. The cited passages also do not establish the claimed cellular-infiltration confounder. (LLM, conf=0.88)

In the section on high contractile activity (page unavailable), the review reports increased total RNA concentration and increased RNA Pol I–transcribed 47S pre-rRNA during skeletal muscle hypertrophy induced by synergist ablation. But it describes evidence from resistance exercise as limited, notes only a tendency toward increased total RNA in humans, and says the role of ribosome biogenesis remains to be clearly elucidated. Thus, the claim that the literature has consistently identified both processes across skeletal muscle hypertrophy overstates the review. (LLM, conf=0.85)

The section on regulation of ribosome biogenesis in response to high contractile activity discusses total RNA measurements and says most hypertrophy studies have focused on translational efficiency. It does not say that bulk-tissue assays or flawed mathematical interpretations systematically confounded the applied hypertrophy literature for decades. Searches for those methodological criticisms found no supporting passage in our copy. (LLM, conf=0.73)

The 'Regulation of ribosome biogenesis in response to high contractile activity' section discusses total RNA and resistance-exercise markers, while 'Perspectives: Ribosome specialization in skeletal muscle' describes microarray findings. Neither passage addresses cellular infiltration as a confounder of whole-muscle RNA-seq; searches for RNA sequencing and infiltration found no passage that does. (LLM, conf=0.73)