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A miRNA Signature in Human Cord Blood Stem and Progenitor Cells as Potential Biomarker of Specific Acute Myeloid Leukemia Subtypes: miRNA PROFILE IN HEMATOPOIETIC STEM CELLS

Cattaneo, M., Pelosi, E., Castelli, G., Cerio, A.M., D′angiò, A., Porretti, L., Rebulla, P., Pavesi, L., Russo, G., Giordano, A., Turri, J., Cicconi, L., Lo-Coco, F., Testa, U., Biunno, Ida·2015·Journal of Cellular Physiology
DOI 10.1002/jcp.24876
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Abstract

MicroRNAs (miRNAs) are important regulators of several cellular processes. During hematopoiesis, specific expression signatures have been reported in different blood cell lineages and stages of hematopoietic stem cell (HSC) differentiation. Here we explored the expression of miRNAs in umbilical cord blood stem (HSC) and progenitor cells (HPC) and compared it to unilineage granulocyte and granulo-monocyte differentiation as well as to primary blasts from patients with acute myeloid leukemia (AML). CD34 + CD38- ad CD34 + CD38 + cells were profiled using a global array consisting of about 2000 miRNAs. An approach combining bioinformatic prediction of miRNA targets with mRNA expression profiling was used to search for putative biologically enriched functions and networks. At least 15 miRNAs to be differentially expressed between HSC and HPC cell population, a cluster of 7 miRNAs are located in the q32 region of human chromosome 14 (miR-377-3p, -136-5p, 376a-3p, 495-3p, 654-3p, 376c-3p and 381-3p) whose expression decreased during the early stages of normal myelopoiesis but were markedly increased in a small set of AML. Interestingly, miR-4739 and -4516, two novel microRNA whose function and targets are presently unknown, showed specific and peculiar expression profile during the hematopoietic stem cells differentiation into unilineages and resulted strongly upregulated in almost all AML subsets. miR-181, -126-5p, -29b-3p and -22-3p resulted dis-regulated in specific leukemias phe…

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Citations

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Research works printed but not linked: 31

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Metadata

Authors
Cattaneo, M., Pelosi, E., Castelli, G., Cerio, A. M., D′angiò, A., Porretti, L., Rebulla, P., Pavesi, L., Russo, G., Giordano, A., Turri, J., Cicconi, L., Lo-Coco, F., Testa, U., & Biunno, I.
Affiliations
  • Institute for Genetic and Biomedical Research; National Council of Research; Milan Italy
  • Department of Hematology; Oncology and Molecular Medicine, Istituto Superiore di Sanita; Rome Italy
  • Department of Regenerative Medicine; IRCCS Ca' Granda Maggiore Policlinico Hospital Foundation; Milan Italy
  • Sbarro Institute for Cancer Research and Molecular Medicine; College of Science and Technology, Temple University; Philadelphia Pennsylvania
  • Department of Biomedicine and Prevention; University Tor Vergata; Rome Italy
Venue
Journal of Cellular Physiology
Publisher
Wiley
Published
2015-04-27
Volume
230
Issue
8
Pages
1770-1780
ISSN
0021-9541
DOI
10.1002/jcp.24876
Cited by
31
References
1
Language
en
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 127 d)
Funders
Agenzia Italiana del Farmaco, Ministero della Salute (RF-MUL-2008-I248034)

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