Meldonium decreases the diet‐increased plasma levels of trimethylamine N‐oxide, a metabolite associated with atherosclerosis
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Meldonium decreased plasma TMAO by increasing urinary excretion in humans.
“Meldonium, a drug that has cardioprotective action, decreased plasma concentrations of TMAO by increasing urinary excretion in humans.”
From Trimethylamine <i>N</i> -Oxide, the Microbiome, and Heart and Kidney Disease (2017) · cites this paper as [36]
Meldonium decreased intestinal microbial-dependent production of TMAO from L-carnitine.
“It also decreased intestinal microbial-dependent production of TMAO from L-carnitine (36,67).”
From Trimethylamine <i>N</i> -Oxide, the Microbiome, and Heart and Kidney Disease (2017) · cites this paper as [36]
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References 19 · Cited by 63
- Authors
- Dambrova, M., Skapare‐Makarova, E., Konrade, I., Pugovics, O., Grinberga, S., Tirzite, D., Petrovska, R., Kalvins, I., & Liepins, E.
- Affiliations
- Latvijas Organiskās Sintēzes Institūts (LV)
- Riga Stradins University Riga Latvia
- Latvian Institute of Organic Synthesis Riga Latvia
- Latvian Biomedical Research and Study Centre (LV)
- Corresponding author
- Dambrova, Maija
- Venue
- The Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2013-07-25
- Volume
- 53
- Issue
- 10
- Pages
- 1095-1098
- ISSN
- 0021-9754 (ISSN-L)
- 0091-2700
- 1552-4604
- OpenAlex
- W2128107962
- Cited by
- 63
- References
- 19
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 12 · 2022: 4 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 1
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- meldonium, trimethylamine N-oxide, atherosclerosis, gut microbiota metabolites, dietary cholesterol
- MeSH terms
- Solute Carrier Family 22 Member 5, Adult, Cardiovascular Agents, Carnitine, Diet, Female, Humans, Male, Methylamines, Methylhydrazines, Seafood, Organic Cation Transport Proteins, Atherosclerosis, HEK293 Cells
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