The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training: Muscle wasting and exercise training
Open accessAbstract
Skeletal muscle provides a fundamental basis for human function, enabling locomotion and respiration. Transmission of external stimuli to intracellular effector proteins via signalling pathways is a highly regulated and controlled process that determines muscle mass by balancing protein synthesis and protein degradation. An impaired balance between protein synthesis and breakdown leads to the development of specific myopathies. Sarcopenia and cachexia represent two distinct muscle wasting diseases characterized by inflammation and oxidative stress, where specific regulating molecules associated with wasting are either activated (e.g. members of the ubiquitin-proteasome system and myostatin) or repressed (e.g. insulin-like growth factor 1 and PGC-1α). At present, no therapeutic interventions are established to successfully treat muscle wasting in sarcopenia and cachexia. Exercise training, however, represents an intervention that can attenuate or even reverse the process of muscle wasting, by exerting anti-inflammatory and anti-oxidative effects that are able to attenuate signalling pathways associated with protein degradation and activate molecules associated with protein synthesis. This review will therefore discuss the molecular mechanisms associated with the pathology of muscle wasting in both sarcopenia and cachexia, as well as highlighting the intracellular effects of exercise training in attenuating the debilitating loss of muscle mass in these specific conditions.
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Cites
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Cited by
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The Role of Inflammation in Age-Related Sarcopenia
Dalle, S., Rossmeislova, L., & Koppo, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01045 · Cited by 668
Skeletal Muscle Regulates Metabolism via Interorgan Crosstalk: Roles in Health and Disease
Argilés, J. M., Campos, N., Lopez-Pedrosa, J. M., Rueda, R., & Rodriguez-Mañas, L. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.04.019 · Cited by 581
Molecular Choreography of Acute Exercise
Contrepois, K., Wu, S., Moneghetti, K. J., Hornburg, D., Ahadi, S., Tsai, M.-S., Metwally, A. A., Wei, E., Lee-McMullen, B., Quijada, J. V., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.043 · Cited by 502
von Haehling, S., Anker, M. S., & Anker, S. D. (2016) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12167 · Cited by 330
Metadata
- Authors
- Bowen, T. S., Schuler, G., & Adams, V.
- Venue
- Journal of Cachexia, Sarcopenia and Muscle
- Publisher
- Wiley
- Published
- 2015-06-03
- Volume
- 6
- Issue
- 3
- Pages
- 197-207
- ISSN
- 2190-5991 (ISSN-L)
- OpenAlex
- W2401761488
- Cited by
- 426
- References
- 32
- FWCI
- 13.51
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bowen, T. S., Schuler, G., & Adams, V. (2015). Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training: Muscle wasting and exercise training. Journal of Cachexia, Sarcopenia and Muscle. https://doi.org/10.1002/jcsm.12043
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