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Impact of creatine supplementation in combination with resistance training on lean mass in the elderly
Abstract
Background: Human ageing is a process characterized by loss of muscle mass, strength, and bone mass. We aimed to examine the efficacy of low‐dose creatine supplementation associated with resistance training on lean mass, strength, and bone mass in the elderly. Methods: This was a 12‐week, parallel‐group, double‐blind, randomized, placebo‐controlled trial. The individuals were randomly allocated into one of the following groups: placebo plus resistance training (PL + RT) and creatine supplementation plus resistance training (CR + RT) . The participants were assessed at baseline and after 12 weeks. The primary outcomes were lean mass and strength, assessed by dual energy X‐ray absorptiometry (DXA) and ten‐repetition maximal tests (10 RM), respectively. Secondary outcomes included the lumbar spine, right and left femoral neck, both femur and whole body bone mineral density (BMD), and whole body bone mineral content (BMC), assessed by DXA. Results: The CR + RT group had superior gains in lean mass when compared with the PL + RT group (P = 0.02). Changes in the 10 RM tests in bench press and leg press exercises, body composition, BMD, and BMC of all assessed sites did not significantly differ between the groups (P > 0.05). Conclusions: Twelve weeks of low‐dose creatine supplementation associated with resistance training resulted in increases in lean mass in the elderly.
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“Subjectively reported side effects include gastrointestinal disturbances [111,214–271], muscle discomfort [111,271,272], overuse trauma [271,273], chest cold [271], and increased sweating/hot flashes [274].”
From Creatine monohydrate supplementation for older adults and clinical populations (2025) · cites this paper as [272]
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Guralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G., Scherr, P. A., & Wallace, R. B. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.m85 · Cited by 9,792
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083 · cited 2×
“Some studies has shown that maintenance, or gain of lean mass was not associated with increases in or maintenance of muscle strength in older adults, demonstrating that muscle strength is not entirely determined by muscle mass.36–38 Goodpaster et al.36 suggests that progressive muscle weakness in the elderly may be re…”
Creatine and Creatinine Metabolism
Wyss, M., & Kaddurah-Daouk, R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1107 · Cited by 2,950
Anthropometric Standardization Reference Manual
Lohman, T. J., Roache, A. F., & Martorell, R. (1992) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199208000-00020 · Cited by 2,764 · cited 1×
“A recognized protocol was followed, as previously documented.(30)”
Longitudinal study of muscle strength, quality, and adipose tissue infiltration
Delmonico, M. J., Harris, T. B., Visser, M., Park, S. W., Conroy, M. B., Velasquez-Mieyer, P., Boudreau, R., Manini, T. M., Nevitt, M., Newman, A. B., et al. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28047 · Cited by 1,446
Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation
Harris, R. C., Söderlund, K., & Hultman, E. (1992) · Clinical Science · doi:10.1042/cs0830367 · Cited by 1,168 · cited 1×
“Existing literature has already demonstrated that creatine supplementation in older and younger individuals can increase muscle creatine and phosphorylcreatine content.(7,44) However, Rawson(45) demonstrated that these increases are smaller in the elderly than in young people.”
Cawthon, P. M., Fox, K. M., Gandra, S. R., Delmonico, M. J., Chiou, C., Anthony, M. S., Sewall, A., Goodpaster, B., Satterfield, S., Cummings, S. R., et al. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02366.x · Cited by 414
Creatine supplementation during resistance training in older adults - a meta-analysis
DEVRIES, M. C., & PHILLIPS, S. M. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000220 · Cited by 239
Creatine supplementation combined with resistance training in older men
CHRUSCH, M. J., CHILIBECK, P. D., CHAD, K. E., SHAWN DAVISON, K., & BURKE, D. G. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200112000-00021 · Cited by 233
Carbohydrate ingestion augments creatine retention during creatine feeding in humans
GREEN, A. L., SIMPSON, E. J., LITTLEWOOD, J. J., MACDONALD, I. A., & GREENHAFF, P. L. (1996) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1996.528300000.x · Cited by 182
In sickness and in health: the widespread application of creatine supplementation
Gualano, B., Roschel, H., Lancha, A. H., Brightbill, C. E., & Rawson, E. S. (2012) · Amino Acids · doi:10.1007/s00726-011-1132-7 · Cited by 172
Effects of 30 days of creatine ingestion in older men
Rawson, E. S., Wehnert, M. L., & Clarkson, P. M. (1999) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/s004210050570 · Cited by 128
Creatine supplementation improves muscular performance in older women
Gotshalk, L. A., Kraemer, W. J., Mendonca, M. A. G., Vingren, J. L., Kenny, A. M., Spiering, B. A., Hatfield, D. L., Fragala, M. S., & Volek, J. S. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0580-y · Cited by 106
Rawson, E. S., Clarkson, P. M., Price, T. B., & Miles, M. P. (2002) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2002.00924.x · Cited by 94
Antonio, J., & Ciccone, V. (2013) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-10-36 · Cited by 83
Creatine supplementation does not improve cognitive function in young adults
Rawson, E. S., Lieberman, H. R., Walsh, T. M., Zuber, S. M., Harhart, J. M., & Matthews, T. C. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.05.009 · Cited by 77
Potential of creatine supplementation for improving aging bone health
Candow, D. G., & Chilibeck, P. D. (2010) · The Journal of nutrition, health and aging · doi:10.1007/s12603-009-0224-5 · Cited by 22
Research works printed but not linked: 26
- Araújo AP, 2014, Morphophysiologial alterations resulted from the process of musculoskeletal system aging and its consequences for the human body, Perspectivas: biológicas e saúde, 4, 22
- 10.1093/ageing/afq034 · DOI · Paper page
- 10.1007/s00726-009-0263-6 · DOI · Paper page
- 10.2165/00007256-199519020-00003 · DOI
- 10.1055/s-2000-8859 · DOI · Paper page
- 10.1097/00005768-200203000-00023 · DOI · Paper page
- Stout JR, 2007, Effects of creatine supplementation on the onset of neuromuscular fatigue threshold and muscle strength in elderly men and women (64–86 years), J Nutr Health Aging, 11, 459
- 10.1007/s12020-013-0070-4 · DOI · Paper page
- 10.1046/j.1365-201X.2003.01050.x · DOI · Paper page
- 10.2165/00007256-200434050-00005 · DOI · Paper page
- 10.1016/j.metabol.2013.09.016 · DOI
- 10.1152/jappl.1996.81.1.232 · DOI · Paper page
- 10.1152/ajpendo.1996.271.5.E821 · DOI · Paper page
- Garber CE, 2014, ACSM's Guidelines for Exercise Testing and Prescription, 162
- Galante AP, 2007, Development and validation of a computerized method for assessment of dietary intake, filled by adults using the Web [dissertation], 1
- 10.1152/jappl.1996.80.2.452 · DOI · Paper page
- 10.1519/JSC.0b013e318278f0db · DOI
- 10.1100/2012/913271 · DOI
- 10.1152/japplphysiol.00246.2003 · DOI · Paper page
- 10.1093/ajcn/65.4.1220S · DOI · Paper page
- 10.1046/j.1365-201X.1998.00427.x · DOI · Paper page
- 10.1152/japplphysiol.00891.2002 · DOI · Paper page
- 10.1519/00139143-200508000-00002 · DOI
- 10.1249/MSS.0000000000000571 · DOI · Paper page
- 10.1007/s00726-011-0855-9 · DOI · Paper page
- 10.1152/jappl.1999.87.2.598 · DOI · Paper page
Cited by
Skeletal muscle aging: influence of oxidative stress and physical exercise
Gomes, M. J., Martinez, P. F., Pagan, L. U., Damatto, R. L., Mariano Cezar, M. D., Ruiz Lima, A. R., Okoshi, K., & Okoshi, M. P. (2017) · Oncotarget · doi:10.18632/oncotarget.14670 · Cited by 285
Gielen, E., Beckwée, D., Delaere, A., De Breucker, S., Vandewoude, M., Bautmans, I., the Sarcopenia Guidelines Development Group of the Belgian Society of Gerontology and Geriatrics (BSGG), Bautmans, I., Beaudart, C., Beckwée, D., et al. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuaa011 · Cited by 269
Chilibeck, P., Kaviani, M., Candow, D., & Zello, G. A. (2017) · Open Access Journal of Sports Medicine · doi:10.2147/oajsm.s123529 · Cited by 235
Candow, D. G., Forbes, S. C., Chilibeck, P. D., Cornish, S. M., Antonio, J., & Kreider, R. B. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8040488 · Cited by 149
Skeletal muscle wasting in chronic heart failure
Suzuki, T., Palus, S., & Springer, J. (2018) · ESC Heart Failure · doi:10.1002/ehf2.12387 · Cited by 134
Metadata
- Authors
- Pinto, C. L., Botelho, P. B., Carneiro, J. A., & Mota, J. F.
- Affiliations
- Laboratory of Research in Clinical Nutrition and Sports (Labince) Faculty of Nutrition Federal University of Goiás St 227, block 68, Setor Leste Universitário Goiânia Goiás 74.605‐080 Brazil
- Faculty of Physical Education Federal University of Goiás Esperança Avenue, Campus Samambaia Goiânia Goiás 74.690‐900 Brazil
- Venue
- Journal of Cachexia, Sarcopenia and Muscle
- Publisher
- Wiley
- Published
- 2016-01-18
- Volume
- 7
- Issue
- 4
- Pages
- 413-421
- ISSN
- 2190-5991
- 2190-6009
- Cited by
- 79
- References
- 18
- Language
- en
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