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Cited by 149Nutrition and Health in AgingMuscle Physiology and DisordersRegulation of Appetite and Obesity

Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia

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Morley, John E.·2017·Journal of Cachexia, Sarcopenia and Muscle
DOI 10.1002/jcsm.12192PMC PMC5566640
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Abstract

The anorexia of aging was first recognized as a physiological syndrome 30 years ago. Its major causes are an alteration in fundal compliance with an increase in antral stretch and enhanced cholecystokinin activity leading to increased satiation.This anorexia leads to weight loss in aging persons and is one of the component causes of the aging related sarcopenia. This physiological anorexia also increases the risk of more severe anorexia when an older person has an increase in inflammatory cytokines such as occurs when they have an illness. This results in an increase in the anorexia due to cachexia in older persons.

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Crossref · 10.1002/jcsm.12192

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  • In advanced age and in acute and chronic illness, nutritional problems are widespread, and reduced dietary intake combined with catabolic disease rapidly leads to malnutrition.

    “Particularly in advanced age and in the case of acute and chronic illness, nutritional problems are widespread, and a reduced dietary intake in combination with the effects of catabolic disease rapidly leads to malnutrition (1,2).”

    From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [1]

    The paper’s Abstract (page unavailable) says that food intake decreases with ageing and that illness-associated inflammation can worsen anorexia and weight loss in older people. It does not establish that nutritional problems are widespread across acute and chronic illness, or that reduced intake combined with catabolic disease rapidly causes malnutrition. (LLM, conf=0.84)

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  • Malnutrition is regarded as one important contributing factor in the complex etiology of sarcopenia and frailty.

    “and is regarded as one important contributing factor in the complex etiology of sarcopenia and frailty (1,3,4).”

    From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [1]

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Research works printed but not linked: 59

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Cited by

Sorted by citations

Authors
Morley, J. E.
Affiliations
Saint Louis University (US)
Corresponding author
Morley, John E.
ORCID
Morley, John E.
Venue
Journal of Cachexia, Sarcopenia and Muscle
Publisher
Wiley
Published
2017-04-27
Volume
8
Issue
4
Pages
523-526
ISSN
  • 2190-5991 (ISSN-L)
  • 2190-6009
DOI
10.1002/jcsm.12192
PMC
PMC5566640
OpenAlex
W2612156186
Cited by
149
References
5
Citations by year
2026: 11 · 2025: 12 · 2024: 19 · 2023: 19 · 2022: 17 · 2021: 12 · 2020: 14 · 2019: 25 · 2018: 13 · 2017: 7
FWCI
11.94
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Cachexia Sarcopenia and Muscle (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
anorexia of aging, sarcopenia, cachexia, cholecystokinin, satiation, inflammatory cytokines, pathogenesis
MeSH terms
Aged, Aging, Anorexia, Cachexia, Humans, Satiation, Weight Loss, Sarcopenia

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