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Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention
Open accessAbstract
Background: Ageing, chronic diseases, prolonged inactivity, and inadequate nutrition pose a severe threat to skeletal muscle health and function. To date, experimental evidence suggests that ageing‐related subclinical inflammation could be an important causative factor in sarcopenia. Although inflammatory signalling has been implicated in the pathogenesis of experimental animal models of sarcopenia, few studies have surveyed the clinical association between circulating factors and muscle mass in patients before and after lifestyle interventions. In this study, we evaluated whether proinflammatory cytokines are associated with the onset of sarcopenia, which circulating factors are associated with the severity of sarcopenia, and how these factors change after lifestyle interventions in sarcopenic elderly persons. Methods: A total of 56 elderly subjects (age ≥ 60 years) with sarcopenia and 56 elderly non‐sarcopenic subjects, who met entry criteria and had given informed consent, were selected from the Peking Union Medical College Hospital multicentre prospective longitudinal sarcopenia study for testing relevant circulating factors. Thirty‐two elderly subjects from the sarcopenic cohort completed a 12 week intensive lifestyle intervention programme with whey supplements (30 g/day) and a personalized resistance training regimen. The levels of proinflammatory cytokines and metabolic hormones, pre‐intensive and post‐intensive lifestyle interventions, were measured. Results: The sarcopenic group was significantly older (72.05 ± 6.54 years; P < 0.001), more likely to be inactive and female (57.1% of all sarcopenic patients), and had a higher prevalence of type 2 diabetes (16% higher risk). Compared with non‐sarcopenic subjects, serum interleukin (IL)‐6, IL‐18, tumour necrosis factor‐α (TNF‐α), TNF‐like weak inducer of apoptosis (TWEAK), and leptin were significantly higher, while insulin growth factor 1, insulin, and adiponectin were significantly lower in sarcopenic patients (all P < 0.05). Logistic regression analyses revealed that high levels of TNF‐α (>11.15 pg/mL) and TWEAK (>1276.48 pg/mL) were associated with a 7.6‐fold and 14.3‐fold increased risk of sarcopenia, respectively. After adjustment for confounding variables, high levels of TWEAK were still associated with a 13.4‐fold increased risk of sarcopenia. Intensive lifestyle interventions led to significant improvements in sarcopenic patients' muscle mass and serum profiles of TWEAK, TNF‐α, IL‐18, insulin, and adiponectin (all P < 0.05). Conclusions: High levels of the inflammatory cytokines TWEAK and TNF‐α are associated with an increased risk of sarcopenia, while the metabolic hormones insulin growth factor 1, insulin, and adiponectin are associated with a decreased risk of sarcopenia in our Chinese patient cohort. Intensive lifestyle interventions could significantly improve muscle mass, reduce inflammation, and restore metabolic hormone levels in sarcopenic patients. This trial was registered at clinicaltrials.gov as NCT02873676.
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“Under pathological conditions, TWEAK also becomes overexpressed and activates the NF‐κB pathway via the FGF‐inducible 14 receptors, leading to increased expression of MuRF1 and activation of the ubiquitin‐proteasome (UPS) pathway as well.[ 69 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [69]
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“Cytokines such as TNF‐α, TNF‐like weak promoter of apoptosis (TWEAK), IL‐18, and IL‐6, are thought to induce muscle atrophy during sarcopenia.[ 69 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [69]
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“Intensive lifestyle interventions lasting 12 weeks (three times a week), including whey supplementation and resistance exercise, can significantly lower the leptin level, restore metabolic hormone levels, and ameliorate muscle mass in sarcopenic patients [85].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [85]
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
Guralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G., Scherr, P. A., & Wallace, R. B. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.m85 · Cited by 9,792
Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia
Chen, L.-K., Liu, L.-K., Woo, J., Assantachai, P., Auyeung, T.-W., Bahyah, K. S., Chou, M.-Y., Chen, L.-Y., Hsu, P.-S., Krairit, O., et al. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.11.025 · Cited by 4,051
Skeletal Muscle Cutpoints Associated with Elevated Physical Disability Risk in Older Men and Women
Janssen, I. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh058 · Cited by 1,190
Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters.
Grünfeld, C., Zhao, C., Fuller, J., Pollack, A., Moser, A. H., Friedman, J. M., & Kr, F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118653 · Cited by 871
Vitamin D Status Predicts Physical Performance and Its Decline in Older Persons
Wicherts, I. S., van Schoor, N. M., Boeke, A. J. P., Visser, M., Deeg, D. J. H., Smit, J., Knol, D. L., & Lips, P. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1525 · Cited by 606
Frisancho, A. R. (1984) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/40.4.808 · Cited by 571
Flagged first, then by citations
1 of the 54 references couldn’t be matched to a known paper.
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Sorted by citations
Tuttle, C. S. L., Thang, L. A. N., & Maier, A. B. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101185 · Cited by 664
Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review
Li, C., Yu, K., Shyh‐Chang, N., Jiang, Z., Liu, T., Ma, S., Luo, L., Guang, L., Liang, K., Ma, W., et al. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12901 · Cited by 626
Self-citationBao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 402
Self-citationInflammation and sarcopenia: A focus on circulating inflammatory cytokines
Pan, L., Xie, W., Fu, X., Lu, W., Jin, H., Lai, J., Zhang, A., Yu, Y., Li, Y., & Xiao, W. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111544 · Cited by 321
Inflammaging: Implications in Sarcopenia
Antuña, E., Cachán-Vega, C., Bermejo-Millo, J. C., Potes, Y., Caballero, B., Vega‐Naredo, I., Coto‐Montes, A. M., & García-González, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315039 · Cited by 234
Inflammaging: The ground for sarcopenia?
Liang, Z., Zhang, T., Liu, H., Li, Z., Peng, L., Wang, C., & Wang, T. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111931 · Cited by 156
Muscle Wasting and Sarcopenia in Heart Failure—The Current State of Science
Lena, A., Anker, M. S., & Springer, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186549 · Cited by 147
Xia, M.-F., Chen, L.-Y., Wu, L., Ma, H., Li, X.-M., Li, Q., Aleteng, Q., Hu, Y., He, W.-Y., Gao, J., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.06.003 · Cited by 133
Sarcopenia: Current treatments and new regenerative therapeutic approaches
Lo, J. C. Y., Kin Pong, U., Yiu, T. L., Ong, M. T., & Lee, W. (2020) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2020.04.002 · Cited by 137
Jiang, M., Ren, X., Han, L., & Zheng, X. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.02.002 · Cited by 114
Chung, S. M., Moon, J. S., & Chang, M. C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.681232 · Cited by 114
Mendoza, K., Smith-Warner, S. A., Rossato, S. L., Khandpur, N., Manson, J. E., Qi, L., Rimm, E. B., Mukamal, K. J., Willett, W. C., Wang, M., et al. (2024) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2024.100859 · Cited by 101
Role of hormones in sarcopenia
Priego, T., Martı́n, A. I., González‐Hedström, D., Granado, M., & López‐Calderón, A. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2020.12.021 · Cited by 103
Searching for the link between inflammaging and sarcopenia
Wang, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101611 · Cited by 90
The relationship between body mass index and stroke: a systemic review and meta-analysis
Wang, X., Huang, Y., Chen, Y., Yang, T., Su, W., Chen, X., Yan, F., Han, L., & Ma, Y. (2022) · Journal of Neurology · doi:10.1007/s00415-022-11318-1 · Cited by 95
Adiponectin and Sarcopenia: A Systematic Review With Meta-Analysis
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Kwon, H., Yun, J. M., Park, J., Cho, B., Han, K., Joh, H., Son, K. Y., & Cho, S. H. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12682 · Cited by 86
Multi-omics research in sarcopenia: Current progress and future prospects
Liu, J., Dong, S., Shen, H., Yang, D.-Y., Chen, B., Ma, X., Peng, Y., Xiao, H., & Deng, H. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101576 · Cited by 83
Li, X., & Ma, L. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102175 · Cited by 83
Ladang, A., Beaudart, C., Reginster, J., Al‐Daghri, N. M., Bruyère, O., Burlet, N., Cesari, M., Cherubini, A., da Silva, M. C., Cooper, C. C., et al. (2023) · Calcified Tissue International · doi:10.1007/s00223-022-01054-z · Cited by 85
Liu, Y., Cui, J., Cao, L., Stubbendorff, A., & Zhang, S. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.10.012 · Cited by 76
Pathophysiology of sarcopenia: Genetic factors and their interplay with environmental factors
Aslam, M. A., Ma, E. B., & Huh, J. Y. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155711 · Cited by 76
Li, Z. Y., Cui, M., Yu, K., Zhang, X., Li, C., Nie, X.-D., & Wang, F. (2020) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2020-0643 · Cited by 66
Self-citationNutritional and lifestyle management of the aging journey: A narrative review
Kassis, A. N., Fichot, M., Horcajada, M.-N., Horstman, A. M. H., Duncan, P. I., Bergonzelli, G. E., Preitner, N., Zimmermann, D., Bosco, N., Vidal, K., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1087505 · Cited by 81
Nutrition in the spotlight in cachexia, sarcopenia and muscle: avoiding the wildfire
Prado, C. M. M., Anker, S. D., Coats, A. J. S., Laviano, A., & von Haehling, S. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12673 · Cited by 65
Paez, H. G., Pitzer, C. R., & Alway, S. E. (2023) · Cells · doi:10.3390/cells12020249 · Cited by 71
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Roy, B., & Palaniyandi, S. S. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00587-4 · Cited by 65
Prokopidis, K., Mazidi, M., Sankaranarayanan, R., Tajik, B., McArdle, A., & Isanejad, M. (2022) · British Journal Of Nutrition · doi:10.1017/s0007114522001787 · Cited by 65
Fochi, S., Giuriato, G., Simone, T. D., Gomez‐Lira, M., Tamburin, S., Piccolo, L. D., Schena, F. F., Venturelli, M., & Romanelli, M. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186732 · Cited by 64
The role and therapeutic potential of stem cells in skeletal muscle in sarcopenia
Cai, Z., Liu, D., Yang, Y., Xie, W., He, M., Yu, D., Wu, Y., Wang, X., Xiao, W., & Li, Y. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02706-5 · Cited by 58
Spatial metabolomics reveals skeletal myofiber subtypes
Luo, L., Ma, W., Liang, K., Wang, Y., Su, J., Liu, R., Liu, T., & Shyh‐Chang, N. (2023) · Science Advances · doi:10.1126/sciadv.add0455 · Cited by 57
Self-citationAutophagy in sarcopenia: Possible mechanisms and novel therapies
Xie, G., Jin, H., Mikhail, H., Pavel, V., Yang, G., Ji, B., Lu, B., & Li, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115147 · Cited by 62
Liu, Z., Guo, Y., & Zheng, C. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1375610 · Cited by 64
Chinese expert consensus on prevention and intervention for elderly with sarcopenia (2023)
Cui, H. L., Wang, Z., Wu, J., Liu, Y., Zheng, J., Xiao, W., He, P., Zhou, Y., Wang, J., Yu, P., et al. (2023) · Aging Medicine · doi:10.1002/agm2.12245 · Cited by 52
Cancer-Associated Muscle Wasting—Candidate Mechanisms and Molecular Pathways
Armstrong, V., Fitzgerald, L. W., & Bathe, O. F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239268 · Cited by 53
Yang, C., Song, Y., Li, T., Chen, X., Zhou, J., Pan, Q., Jiang, W., Wang, M., & Jia, H. (2023) · The journal of nutrition health & aging · doi:10.1007/s12603-023-1911-1 · Cited by 55
Gellhaus, B., Böker, K. O., Schilling, A. F., & Saul, D. (2023) · Cells · doi:10.3390/cells12242787 · Cited by 54
Whey for Sarcopenia; Can Whey Peptides, Hydrolysates or Proteins Play a Beneficial Role?
Gilmartin, S., O’Brien, N. M., & Giblin, L. (2020) · Foods · doi:10.3390/foods9060750 · Cited by 53
Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions
Wang, T., Zhou, D., & Hong, Z. (2025) · MedComm · doi:10.1002/mco2.70030 · Cited by 46
Diagnostics of inflammaging in relation to sarcopenia
Morawin, B., Tylutka, A., Bielewicz, F., & Zembroń-Łacny, A. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1162385 · Cited by 49
Cheng, Y., Lin, S., Cao, Z., Yu, R., Fan, Y., & Chen, J. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114056 · Cited by 55
Gong, H., Liu, Y., Lyu, X., Dong, L., & Zhang, X. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111668 · Cited by 51
Nunes-Pinto, M., de Mello, R. G. B., Pinto, M. N., Moro, C., Vellas, B. J., Martinez, L. O., Rolland, Y., & Barreto, P. D. S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102587 · Cited by 52
Kim, J., Lee, J.-Y., & Kim, C. Y. (2023) · Nutrients · doi:10.3390/nu15112625 · Cited by 45
Immunoregulation in cancer-associated cachexia
Wu, Q., Liu, Z., Li, B., Liu, Y., & Wang, P. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.04.018 · Cited by 42
Ding, J., Yang, G., Sun, W., Li, Y., Wang, N., Wang, J., & Zhao, Y. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2384664 · Cited by 38
He, J., Huang, M., Li, N., Zha, L., & Yuan, J. (2023) · Nutrients · doi:10.3390/nu15133013 · Cited by 36
Tu, S., Hao, X., Xu, S., Jin, X., Liao, W., Xia, H., Wang, S., & Sun, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146740 · Cited by 46
Lin, Y., Zhang, Q., Yang, Y., & Zhou, J. (2022) · International Journal of Endocrinology · doi:10.1155/2022/4026940 · Cited by 36
Ge, Y., Ruan, G., Zhang, Q., Dong, W., Zhang, X., Song, M., Zhang, X., Li, X.-R., Zhang, K., Tang, M., et al. (2022) · Nutrition & Metabolism · doi:10.1186/s12986-022-00667-3 · Cited by 33
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Ali, S. R., Nkembo, A. T., Tipparaju, S. M., Ashraf, M., & Xuan, W. (2024) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2024-0201 · Cited by 37
Son, B., Akishita, M., Yamanaka, T., Toyoshima, K., Tanaka, T., Unyaporn, S., & Iijima, K. (2021) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2021.104481 · Cited by 33
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Yoo, J. E., Han, K., Jung, J., Hur, Y., Kim, Y., Kim, E. S., Son, J. W., Rhee, E., Lee, W., & Nam, G. E. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13138 · Cited by 32
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Sarcopenia versus cancer cachexia: the muscle wasting continuum in healthy and diseased aging
Moreira‐Pais, A., Ferreira, R. M., Oliveira, P. A., & Duarte, J. A. (2021) · Biogerontology · doi:10.1007/s10522-021-09932-z · Cited by 31
Hu, Q., Mao, W., Wu, T., Xu, Z., Yu, J., Wang, C., Chen, S., Chen, S., Xu, B., Xu, Y., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.736640 · Cited by 31
Sarcopenia and perioperative management of elderly surgical patients
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Gao, H.-E., Wu, D.-S., Sun, L., Yang, L., Qiao, Y., Ma, S., Wu, Z., Ruan, L., & Li, F. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111262 · Cited by 29
Hill, M., Třískala, Z., Honců, P., Krejčí, M., Kajzar, J., Bičı́ková, M., Ondřejíková, L., Jandová, D., & Sterzl, I. (2020) · Physiological Research · doi:10.33549/physiolres.934523 · Cited by 31
Barrea, L., Vetrani, C., Caprio, M., Cataldi, M., Ghoch, M. E., Elce, A., Camajani, E., Verde, L., Savastano, S., Colao, A., et al. (2022) · Current Obesity Reports · doi:10.1007/s13679-022-00475-z · Cited by 33
Ginseng and ginsenosides: Therapeutic potential for sarcopenia
Zha, W., Sun, Y., Gong, W., Li, L., Kim, W., & Li, H. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113876 · Cited by 31
Sarcopenia and COVID-19 Outcomes
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Deng, F., Wu, W., Fan, X., Zhong, X., Wang, N., Wang, Y., Pan, T., & Du, Y. (2023) · International Journal of Endocrinology · doi:10.1155/2023/9926462 · Cited by 26
Azizan, A. (2023) · International Journal of Disabilities Sports & Health Sciences · doi:10.33438/ijdshs.1362539 · Cited by 29
López-Gómez, J. J., García-Beneitez, D., Jiménez-Sahagún, R., Izaola-Jáuregui, O., Primo-Martín, D., Ramos-Bachiller, B., Gómez-Hoyos, E., Delgado-García, E., Pérez-López, P., & de Luis-Román, D. D. (2023) · Nutrients · doi:10.3390/nu15183923 · Cited by 22
Guo, J., Shang, Y., Fratiglioni, L., Johnell, K., Welmer, A., Marseglia, A., & Xu, W. (2021) · Age and Ageing · doi:10.1093/ageing/afab045 · Cited by 26
Huang, S.-W., Xu, T., Zhang, C.-T., & Zhou, H.-L. (2020) · The journal of nutrition health & aging · doi:10.1007/s12603-020-1329-0 · Cited by 26
Bian, D., Xuan, C., Li, X., Zhou, W., Lu, Y., Ding, T., Shen, J., Shi, Y., & Li, G. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-03938-7 · Cited by 25
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Liang, Z., & Zhang, L. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1733798 · Cited by 32
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Jiang, W., Zhan, W., Zhou, L., Dong, M., Liu, L., Xu, X. S., & Cao, Z. (2023) · Age and Ageing · doi:10.1093/ageing/afad024 · Cited by 23
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Liu, M., Li, J. J., Xu, J., Chen, Y., Chien, C., Zhang, H., Zhang, Q., & Wang, L. (2024) · Clinical Interventions in Aging · doi:10.2147/cia.s473081 · Cited by 33
Huang, N., Ge, M., Liu, X., Tian, X., Yin, P., Bao, Z., Cao, F., Shyh‐Chang, N., Dong, B., Dai, L., et al. (2024) · Life Medicine · doi:10.1093/lifemedi/lnaf001 · Cited by 27
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Wumaer, A., Maimaitiwusiman, Z., Xiao, W., Xuekelati, S., Liu, J., Musha, T., & Wang, H. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.788178 · Cited by 21
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Zhang, B., Huang, L., Zhu, X., Ran, L., Zhao, H., Zhu, Z., & Wang, Y. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.162814 · Cited by 21
Taheri, M., Chilibeck, P. D., & Cornish, S. M. (2023) · Nutrients · doi:10.3390/nu15132926 · Cited by 23
Sun, R., Wan, J., Tang, J., Deng, Y., Zhang, M., Li, J., Li, J., & Zhang, Q. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105595 · Cited by 27
Xiong, L., Chen, Y., Dong, X., Li, Y., Min De, Z. E. N. G., & Liu, K. (2023) · BioMed Research International · doi:10.1155/2023/4839210 · Cited by 20
RetractedWang, F., Dou, P., Wei, W., & Liu, P. J. (2024) · Nutrition & Diabetes · doi:10.1038/s41387-024-00263-9 · Cited by 20
Research Progress on the Effect and Mechanism of Exercise Intervention on Sarcopenia Obesity
Chen, J., Jia, S., Guo, C., Fan, Z., Yan, W., & Dong, K. (2024) · Clinical Interventions in Aging · doi:10.2147/cia.s473083 · Cited by 22
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Ho, T., Tang, C., Chang, S. L., Tsai, C., Chen, H., & Su, C. (2022) · Cells · doi:10.3390/cells11233936 · Cited by 20
Li, C., Yu, K., Shyh‐Chang, N., Li, G., Yu, S., Liu, H., Yang, B., Li, Z., Zhao, Y., Xu, L., et al. (2021) · Cell Proliferation · doi:10.1111/cpr.12989 · Cited by 19
Self-citationImpact of Osteopenia on Oncologic Outcomes After Curative Resection for Pancreatic Cancer
Motomura, T., Uchiyama, H., Iguchi, T., Ninomiya, M., Yoshida, R., Honboh, T., Sadanaga, N., Akashi, T., & MATSUURA, H. (2020) · In Vivo · doi:10.21873/invivo.12198 · Cited by 18
Yao, J., & Xia, S. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1541373 · Cited by 21
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Huschtscha, Z., Parr, A., Porter, J. A., & Costa, R. J. S. (2021) · Sports Medicine - Open · doi:10.1186/s40798-021-00323-9 · Cited by 17
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Wolf, V. L. W., Breder, I. S. S., de Carvalho, L. S. F., Soares, A., Cintra, R. M. R., Barreto, J., Munhoz, D., Kimura-Medorima, S. T., Nadruz, W., Guerra‐Júnior, G., et al. (2021) · Nutrition and Diabetes · doi:10.1038/s41387-021-00160-5 · Cited by 17
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Yin, G., Qin, J., Wang, Z., Lv, F., & Ye, X. (2023) · Medicine · doi:10.1097/md.0000000000033581 · Cited by 17
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Chen, Y., Hu, Q., Wang, C., & Wang, T. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1132830 · Cited by 16
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Rentflejsz, J., & Wojszel, Z. B. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13041107 · Cited by 18
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Mondal, S., Rathor, R., Singh, S. N., & Suryakumar, G. (2024) · Pharmacology Research & Perspectives · doi:10.1002/prp2.1248 · Cited by 18
Teixeira, L. A. D. C., dos Santos, J., Parentoni, A. N., Lima, L. D., Duarte, T. C., Brant, F. P., Neves, C. D. C., Pereira, F. S. M., de Avelar, N. C. P., Danielewicz, A. L., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11237175 · Cited by 18
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Marmondi, F., Ferrando, V., Filipas, L., Codella, R., Ruggeri, P., Torre, A. L., Faelli, E. L., & Bonato, M. (2025) · Sports · doi:10.3390/sports13120444 · Cited by 21
Metadata
- Authors
- Li, C., Yu, K., Shyh‐Chang, N., Li, G., Jiang, L., Yu, S., Xu, L., Liu, R., Guo, Z., Xie, H., Li, R., Ying, J., Li, K., & Li, D.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese Academy of Sciences (CN)
- Department of General Surgery and Clinical Nutrition TianJin Union Medical Center Hongqiao District Tianjin China
- Department of Central Laboratory Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Dongcheng District Beijing China
- Department of Clinical Laboratory Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Dongcheng District Beijing China
- Department of Health Care Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Dongcheng District Beijing China
- Department of Clinical Nutrition and Department of Health Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Dongcheng District Beijing China
- Corresponding author
- Yu, Kang
- Shyh‐Chang, Ng
- Venue
- Journal of Cachexia, Sarcopenia and Muscle
- Publisher
- Wiley
- Published
- 2019-04-10
- Volume
- 10
- Issue
- 3
- Pages
- 586-600
- ISSN
- 2190-5991 (ISSN-L)
- 2190-6009
- PMC
- PMC6596393
- OpenAlex
- W2938744410
- Cited by
- 280
- References
- 54
- Citations by year
- 2026: 26 · 2025: 46 · 2024: 54 · 2023: 71 · 2022: 41 · 2021: 25 · 2020: 17
- FWCI
- 14.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Cachexia Sarcopenia and Muscle (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Chinese Academy of Sciences (XDA16020301, KJZD-SW-L04)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- sarcopenia, aging, inflammatory cytokines, TWEAK, TNF-α, interleukin-6, IL-18, leptin, insulin-like growth factor I, adiponectin, whey protein supplementation, resistance training, lifestyle intervention, older adults, muscle mass, subclinical inflammation, type 2 diabetes, metabolic hormones, sarcopenia risk
- MeSH terms
- Healthy Lifestyle, Cytokine TWEAK, Aged, Aging, Body Composition, China, Cross-Sectional Studies, Female, Humans, Inflammation, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Severity of Illness Index, Tumor Necrosis Factor-alpha, Treatment Outcome, Muscle, Skeletal, Inflammation Mediators, Resistance Training, Sarcopenia
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