Doppler examination of uteroplacental circulation in early pregnancy: can it predict adverse outcome?
Abstract
PURPOSE: To determine whether spectral Doppler measurements obtained from bilateral uterine, arcuate, radial, and spiral arteries in early gestation correlate with adverse pregnancy outcome. METHODS: One hundred five pregnant women underwent transvaginal Doppler sonographic examination of uteroplacental circulation at 6-12 weeks' gestation. Resistance index (RI) and pulsatility index (PI) of bilateral uterine, arcuate, radial, and spiral arteries were measured. Diameters of gestational sac (GS) and yolk sac, crown-rump length (CRL), GS-CRL difference, and GS/CRL ratio were also recorded. Correlation was made with pregnancy outcome. RESULTS: Sixteen women developed adverse pregnancy outcome. In these women, right uterine artery PI and RI were significantly higher than in women with normal obstetrical outcome. Spiral artery PI and RI values were also higher, but the difference was not statistically significant. GS-CRL difference, GS/CRL ratio, and yolk sac diameters were significantly lower in this group. CONCLUSION: Transvaginal Doppler examination can detect hemodynamic changes in uteroplacental circulation associated with subsequent adverse pregnancy outcome.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mathematical modelling demonstrates that the vessels most likely to be directly responsible for the changes seen in the uterine artery waveform are the radial arteries and not the spiral arteries.
“This has been modelled mathematically demonstrating that the vessels most likely to be directly responsible for the changes seen in the uterine artery waveform are the radial arteries [50] and not the spiral arteries.”
From Volume and vascularity: Using ultrasound to unlock the secrets of the first trimester placenta (2019) · cites this paper as [50]
Cites
Papageorghiou, A. T., Yu, C.-S., Bindra, R., Pandis, G. K., & Nicolaides, K. H. (2001) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.0960-7692.2001.00572.x · Cited by 538 · see citing works
Martin, A., Bindra, R. R., Curcio, P., Cicero, S., & Nicolaides, K. H. (2001) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.0960-7692.2001.00594.x · Cited by 452 · see citing works
Aardema, M. W., Oosterhof, H., Timmer, A., van Rooy, I., & Aarnoudse, J. G. (2001) · Placenta · doi:10.1053/plac.2001.0676 · Cited by 231 · see citing works
Bewley, S., COOPER, D., & Campbell, S. C. (1991) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1991.tb13508.x · Cited by 221 · see citing works
Prefumo, F. (2003) · Human Reproduction · doi:10.1093/humrep/deh037 · Cited by 211 · see citing works
The role of ultrasound imaging in diagnosing and investigating early pregnancy failure
Jauniaux, E. R. M., Johns, J., & Burton, G. J. (2005) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.1892 · Cited by 186 · see citing works
Vainio, M., Kujansuu, E., Isomustajärvi, M., & Mäenpää, J. (2002) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2002.01046.x · Cited by 180 · see citing works
Harrington, K., Goldfrad, C. H., Carpenter, R. G., & Campbell, S. C. (1997) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1997.09020094.x · Cited by 150 · see citing works
Habara, T. (2002) · Human Reproduction · doi:10.1093/humrep/17.1.190 · Cited by 141 · see citing works
Harrington, K., Carpenter, R. G., Goldfrad, C. H., & Campbell, S. C. (1997) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1997.tb11977.x · Cited by 132 · see citing works
Dugoff, L., Lynch, A. M., Cioffi‐Ragan, D., Hobbins, J. C., Schultz, L. K., Malone, F. D., & D’Alton, M. E. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.06.054 · Cited by 114 · see citing works
Yang, J.-H., Wu, M.-Y., Chen, C.-D., Jiang, M.-C., Ho, H., & Yang, Y.-S. (1999) · Human Reproduction · doi:10.1093/humrep/14.6.1606 · Cited by 108 · see citing works
Schuchter, K., Metzenbauer, M., Hafner, E., & Philipp, K. (2001) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.0960-7692.2001.00596.x · Cited by 95 · see citing works
Longitudinal evaluation of uteroplacental and umbilical blood flow changes in normal early pregnancy
Coppens, M., Loquet, P., Kollen, M., Neubourg, F. D., & Buytaert, P. (1996) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1996.07020114.x · Cited by 92 · see citing works
Goffinet, F., Aboulker, D., Paris-Llado, J., Bucourt, M., Uzan, M., Papiernik, E., & Bréart, G. (2001) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2001.00116.x · Cited by 81 · see citing works
Hollis, B., Mavrides, E., Campbell, S. C., Tekay, A., & Thilaganathan, B. (2001) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.0960-7692.2001.00544.x · Cited by 79 · see citing works
Uteroplacental Circulation Development: Doppler Assessment and Clinical Importance
Carbillon, L., Challier, J.-C., Alouini, S., Uzan, M., & Uzan, S. (2001) · Placenta · doi:10.1053/plac.2001.0732 · Cited by 74 · see citing works
Chien, L. W., Lee, W. S., Au, H., & Tzeng, C. (2004) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.975 · Cited by 73 · see citing works
van den Elzen, H. J., Cohen‐Overbeek, T. E., Grobbee, D. E., Quartero, R. W. P., & Wladimiroff, J. W. (1995) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1995.05050328.x · Cited by 71 · see citing works
Current topic: In Vivo investigation of the placental circulations by doppler echography
Jauniaux, E. R. M., Jurkovic, D., & Campbell, S. (1995) · Placenta · doi:10.1016/0143-4004(95)90089-6 · Cited by 69 · see citing works
First‐trimester uterine artery blood flow and birth weight
Hollis, B., Prefumo, F., Bhide, A., Rao, S., & Thilaganathan, B. (2003) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.231 · Cited by 56 · see citing works
Jaffe, R. B., & Warsof, S. L. (1991) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(91)90515-s · Cited by 53 · see citing works
Jaffe, R. B., Dorgan, A., & Abramowicz, J. S. (1995) · American Journal of Roentgenology · doi:10.2214/ajr.164.5.7717242 · Cited by 53 · see citing works
Prognostic significance of the human yolk sac assessed by ultrasonography
Reece, E. A., Scioscia, A. L., Pinter, E., Hobbins, J. C., Green, J. L., Mahoney, M. J., & Naftolin, F. N. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(88)90445-0 · Cited by 49 · see citing works
Impaired Uterine Arterial Blood Flow in Pregnant Women With Recurrent Pregnancy Loss
Nakatsuka, M., Habara, T., Noguchi, S., Konishi, H., & Kudo, T. (2003) · Journal of Ultrasound in Medicine · doi:10.7863/jum.2003.22.1.27 · Cited by 46 · see citing works
Dickey, R. P., Olar, T. T., Taylor, S., Curole, D. N., & Matulich, E. M. (1992) · PubMed · Cited by 43 · see citing works
Doppler ultrasonography in early pregnancy does not predict adverse pregnancy outcome
Arduini, D., Rizzo, G., & Romaninï, C. (1991) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1991.01030180.x · Cited by 29 · see citing works
Delayed normalisation of uterine artery doppler waveforms is not a benign phenomenon
Kurdi, W., Fayyad, A. M., Thakur, V., & Harrington, K. (2004) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2003.10.038 · Cited by 26 · see citing works
The assessment of normal early pregnancy by transvaginal color Doppler ultrasonography
Kurjak, A., Crvenkovic, G., Salihagić, A., Žalud, I., & Miljan, M. (1993) · Journal of Clinical Ultrasound · doi:10.1002/jcu.1870210103 · Cited by 26 · see citing works
Tadmor, O. P., Achiron, R., Rabinowiz, R., Aboulafia, Y., Mashiach, S., & Diamant, Y. Z. (1994) · PubMed · Cited by 25 · see citing works
First trimester uterine, placental and yolk sac haemodynamics in pre-eclampsia and preterm labour
Mäkikallio, K. (2004) · Human Reproduction · doi:10.1093/humrep/deh106 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ahmed, F., Abbas, S., Athar, A., Shahzad, T., Khan, W. A., Alharbi, M., Khan, M. A., & Ahmed, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-56478-4 · Cited by 71 · see citing works
Li, Y. L., Hyun, D., Abou‐Elkacem, L., Willmann, J. K., & Dahl, J. (2016) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2016.2616112 · Cited by 60 · see citing works
Collins, S. L., Birks, J. S., Stevenson, G. N., Papageorghiou, A. T., Noble, J. A., & Impey, L. (2012) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.10149 · Cited by 55 · see citing works
Sildenafil Increases Uterine Blood Flow in Nonpregnant Nulliparous Women
Hale, S. A., Jones, C., Osol, G., Schonberg, A. L., Badger, G. J., & Bernstein, I. M. (2010) · Reproductive Sciences · doi:10.1177/1933719109354648 · Cited by 42 · see citing works
Gebb, J. S., & Dar, P. (2011) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2011.01.008 · Cited by 41 · see citing works
Spiral artery blood flow during pregnancy: a systematic review and meta-analysis
Schiffer, V. M. M. M., Evers, L., de Haas, S., Ghossein‐Doha, C., Al‐Nasiry, S., & Spaanderman, M. E. A. (2020) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-020-03150-0 · Cited by 40 · see citing works
Collins, S., Stevenson, G. N., Noble, J. A., & Impey, L. W. M. (2012) · Placenta · doi:10.1016/j.placenta.2012.07.005 · Cited by 40 · see citing works
Volume and vascularity: Using ultrasound to unlock the secrets of the first trimester placenta
Mathewlynn, S., & Collins, S. L. (2019) · Placenta · doi:10.1016/j.placenta.2019.06.379 · Cited by 30 · see citing works
Contrast-Enhanced Ultrasound for the Assessment of Placental Development and Function
Roberts, V. H. J., & Frias, A. E. (2020) · BioTechniques · doi:10.2144/btn-2020-0069 · Cited by 30 · see citing works
Schabel, M. C., Roberts, V. H. J., Gibbins, K. J., Rincon, M. P., Gaffney, J. E., Streblow, A. D., Wright, A. M., Lo, J. O.-T., Park, B. S., Kroenke, C. D., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0270360 · Cited by 29 · see citing works
Relationship Between Prepregnancy and Early Pregnancy Uterine Blood Flow and Resistance Index
Hale, S. A., Schonberg, A. L., Badger, G. J., & Bernstein, I. M. (2009) · Reproductive Sciences · doi:10.1177/1933719109341843 · Cited by 25 · see citing works
Özkan, M. B., Özyazıcı, E., Emiroglu, B., & Özkara, E. (2015) · Australasian Journal of Ultrasound in Medicine · doi:10.1002/j.2205-0140.2015.tb00043.x · Cited by 19 · see citing works
Study of the development of uteroplacental and fetal feline circulation by triplex Doppler
Pereira, B. S., Pinto, J. N., Freire, L. M. P., Campello, C. C., Domingues, S. F. S., & da Silva, L. D. M. (2011) · Theriogenology · doi:10.1016/j.theriogenology.2011.10.005 · Cited by 16 · see citing works
Uterine artery Doppler screening as a predictor of pre-eclampsia
Casmod, Y., Dyk, B. V., & Nicolaou, E. (2016) · Health SA Gesondheid · doi:10.1016/j.hsag.2016.06.004 · Cited by 16 · see citing works
Persistent Left Superior Vena Cava: Why is Prenatal Diagnosis Important?
Keleş, A., Yılmaz, O., Dağdeviren, G., CELİK, O. Y., Yücel, A., & Şahın, D. (2021) · Fetal and Pediatric Pathology · doi:10.1080/15513815.2021.1933662 · Cited by 15 · see citing works
Turna, Ö., Gündüz, M. C., Dal, G. E., Uçmak, M., Uçmak, Z. G., Karaçam, E., Kaşıkçı, G., & Kiliçarslan, M. R. (2015) · Theriogenology · doi:10.1016/j.theriogenology.2015.09.010 · Cited by 15 · see citing works
Beneventi, F., Locatelli, E., Ramoni, V. L., Caporali, R. F., Montecucco, C., Simonetta, M., Cavagnoli, C., Ferrari, M. M., & Spinillo, A. (2012) · Prenatal Diagnosis · doi:10.1002/pd.3964 · Cited by 13 · see citing works
Uterine artery Doppler ultrasound in second pregnancy with previous elective cesarean section*
Torabi, S., Sheikh, M., Masrour, F. F., Shamshirsaz, A. A., Bateni, Z. H., Nassr, A. A., Pooransari, P., Talebian, M., & Hantoushzadeh, S. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1430132 · Cited by 10 · see citing works
A mathematical model of vascular and hemodynamics changes in early and late forms of preeclampsia
Sedaghati, F., & Gleason, R. L. (2023) · Physiological Reports · doi:10.14814/phy2.15661 · Cited by 9 · see citing works
Doppler evaluation of maternal vessels in normal gestation and threatened abortion in canines
Gaikwad, S. M., Gulavane, S. U., Kumbhar, U. B., Shelar, R. R., Chaudhari, R. J., & Ann, R. R. (2020) · Irish Veterinary Journal · doi:10.1186/s13620-020-00169-9 · Cited by 8 · see citing works
Gleason, R. L., & Sedaghati, F. (2022) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-021-01555-0 · Cited by 6 · see citing works
Bhoil, R., Kaushal, S., Sharma, R., Kaur, J., Sharma, T., Thakur, R., & Sharma, R. (2019) · Journal of Ultrasonography · doi:10.15557/jou.2019.0038 · Cited by 6 · see citing works
Postpartum Pseudoaneurysm After Cesarean Delivery
DiGiacinto, D. D., Bagley, J. E., Gildon, B. W., & Cantrell, G. (2018) · Journal of diagnostic medical sonography · doi:10.1177/8756479318816985 · Cited by 5 · see citing works
Sammut, L., Bezzina, P., Gibbs, V., & Calleja‐Agius, J. (2024) · Radiography · doi:10.1016/j.radi.2024.07.022 · Cited by 3 · see citing works
Akkuş, T., Emre, B., & Yaprakcı, Ö. (2023) · Animal Health Production and Hygiene · doi:10.53913/aduveterinary.1326273 · Cited by 2 · see citing works
Sodhi, K. S., Kritsaneepaiboon, S., Jana, M., & Bhatia, A. (2023) · Pediatric Radiology · doi:10.1007/s00247-023-05787-3 · Cited by 2 · see citing works
Ultrasonographic Signs of Poor Pregnancy Outcome
Serrano-González, L., Martinez-Moya, M., Platero-Mihi, M., Bajo-Arenas, J., & Pérez‐Medina, T. (2015) · Donald School Journal of Ultrasound in Obstetrics & Gynecology · doi:10.5005/jp-journals-10009-1503 · Cited by 1 · see citing works
Adan, R., Sirinoglu, H. A., Şahin, F., & Özdemir, S. (2024) · Clinical and Experimental Obstetrics & Gynecology · doi:10.31083/j.ceog5106127 · Cited by 1 · see citing works
Reactive Oxygen Species (ROS) and the Uterine Circulation
Stanley, J. L., & Davidge, S. T. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_110 · Cited by 1 · see citing works
Kedilerde Güç Doğum Sırasında Fötal ve Föto-Maternal Damarların Doppler Değerlendirilmesi: Dört Olgu
Turna, Ö., Uçmak, M., Uçmak, Z. G., Karaçam, E., & Erzengin, Ö. M. (2014) · Kafkas Universitesi Veteriner Fakultesi Dergisi · doi:10.9775/kvfd.2014.11352
Reactive Oxygen Species and the Uterine Circulation 122
Stanley, J. L., & Davidge, S. T. (2014)
Coherent flow power Doppler imaging
Li, Y. L. (2017)
OKÇU, N. T., & GÜRBÜZ, T. (2021) · Journal of Surgery and Medicine · doi:10.28982/josam.889709
Current awareness in prenatal diagnosis
(2008) · Prenatal Diagnosis · doi:10.1002/pd.1853
Mishra, S., Gupta, M., Agarwal, N., Agrawal, A., & Shukla, A. K. (2023) · Santosh University Journal of Health Sciences · doi:10.4103/sujhs.sujhs_21_23
Doppler in threatened abortion
Gupta, M., Mishra, S., & Agarwal, N. (2023) · Santosh University Journal of Health Sciences · doi:10.4103/sujhs.sujhs_20_23
Al-Tubaikh, J. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-28575-2_8
Shojaei, K., Elahian, S., Saadati, N., Jafari, R. M., Gharibvand, M. M., Seyedtabib, M., & Mohammadi, S. (2023) · Current Women s Health Reviews · doi:10.2174/1573404820666230823153426
Zakaria, A. M., Diab, Y. M. S. K., & Khatab, A. T. I. (2023) · Al-Azhar International Medical Journal /Al-Azhar International Medical Journal · doi:10.58675/2682-339x.1989
Effect of Physical Activity on Portal Vein Resistance Index
Vinogradov, A. A., Andreeva, I. V., & Simakova, E. S. (2023) · I P Pavlov Russian Medical Biological Herald · doi:10.17816/pavlovj109095
Use of ultrasonography for fetal circulation assessment in canine pregnancy: A review
Fernandes, M. P., Xavier, G. M., Baptista, M. F. B., Loiola, M. V. G., & Filho, A. D. L. R. (2025) · Revista Brasileira de Saúde e Produção Animal · doi:10.1590/20240032
- Authors
- Özkaya, Ü., Özkan, S., Özeren, S., & Çorakçı, A.
- Affiliations
- Kocaeli Üniversitesi (TR)
- Corresponding author
- Özkan, Sebiha
- Venue
- Journal of Clinical Ultrasound
- Publisher
- Wiley
- Published
- 2007-06-05
- Volume
- 35
- Issue
- 7
- Pages
- 382-386
- ISSN
- 0091-2751 (ISSN-L)
- 1097-0096
- OpenAlex
- W2151194667
- Cited by
- 37
- References
- 31
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 3 · 2012: 2
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Ultrasound (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Keywords
- uteroplacental circulation, early pregnancy, adverse pregnancy outcomes, uterine artery, arcuate arteries, radial artery, spiral arteries, resistance index, pulsatility index, gestational sac, crown-rump length, yolk sac, fetal growth restriction
- MeSH terms
- Adult, Female, Humans, Placenta, Predictive Value of Tests, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Pregnancy Trimester, First, Uterus, Ultrasonography, Interventional, Ultrasonography, Doppler, Placental Circulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review