Negative regulation of type I IFN signaling
Abstract
Type I IFNs (α, β, and others) are a family of cytokines that are produced in physiological conditions as well as in response to the activation of pattern recognition receptors. They are critically important in controlling the host innate and adaptive immune response to viral and some bacterial infections, cancer, and other inflammatory stimuli. However, dysregulation of type I IFN production or response can contribute to immune pathologies termed “interferonopathies”, pointing to the importance of balanced activating signals with tightly regulated mechanisms of tuning this signaling. Here, we summarize the recent advances of how type I IFN production and response are controlled at multiple levels of the type I IFN signaling cascade.
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This may help explain the poor prediction of in vivo TF occupancy from in vitro binding affinities, often using only DNA binding domains.
“This may help explain the poor prediction of in vivo TF occupancy from in vitro binding affinities (often using only DNA binding domains)48.”
From Single-molecule states link transcription factor binding to gene expression (2024) · cites this paper as [48]
Cites
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Interferon-Stimulated Genes: What Do They All Do?
Schoggins, J. W. (2019) · Annual Review of Virology · doi:10.1146/annurev-virology-092818-015756 · Cited by 1,036 · see citing works
Type I interferons and endoplasmic reticulum stress in health and disease
(2020) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.10.004 · Cited by 83 · see citing works
Single-molecule states link transcription factor binding to gene expression
Doughty, B. R., Hinks, M. M., Schaepe, J. M., Marinov, G. K., Thurm, A. R., Rios-Martinez, C., Parks, B. E., Tan, Y., Marklund, E., Dubocanin, D., et al. (2024) · Nature · doi:10.1038/s41586-024-08219-w · Cited by 42 · see citing works
- Authors
- Arimoto, K.-I., Miyauchi, S., Stoner, S. A., Fan, J.-B., & Zhang, D.-E.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Zhang, Dong-Er
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-01-22
- Volume
- 103
- Issue
- 6
- Pages
- 1099-1116
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2789519809
- Cited by
- 117
- References
- 10
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 19 · 2023: 15 · 2022: 15 · 2021: 17 · 2020: 10 · 2019: 16 · 2018: 5
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Leukocyte Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- type I interferon, interferon signaling, negative regulation, interferonopathies, innate immunity, antiviral immunity, pattern recognition receptors, immune regulation, viral infection, cancer
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