Type I interferons in infectious disease

McNab, Finlay; Mayer-Barber, Katrin; Sher, Alan; Wack, Andreas; O'Garra, Anne

doi:10.1038/nri3787

Cited by 2,780interferon and immune responsesImmune Response and InflammationCytokine Signaling Pathways and Interactions

Type I interferons in infectious disease

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McNab, Finlay, Mayer-Barber, Katrin, Sher, Alan, Wack, Andreas, O'Garra, Anne·2015·Nature Reviews Immunology

DOI 10.1038/nri3787PMC PMC7162685

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Abstract

Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the induction of other mediators. Type I IFNs are important for host defence against viruses. However, recently, they have been shown to cause immunopathology in some acute viral infections, such as influenza virus infection. Conversely, they can lead to immunosuppression during chronic viral infections, such as lymphocytic choriomeningitis virus infection. During bacterial infections, low levels of type I IFNs may be required at an early stage, to initiate cell-mediated immune responses. High concentrations of type I IFNs may block B cell responses or lead to the production of immunosuppressive molecules, and such concentrations also reduce the responsiveness of macrophages to activation by IFNγ, as has been shown for infections with Listeria monocytogenes and Mycobacterium tuberculosis. Recent studies in experimental models of tuberculosis have demonstrated that prostaglandin E2 and interleukin-1 inhibit type I IFN expression and its downstream effects, demonstrating that a cross-regulatory network of cytokines operates during infectious diseases to provide protection with minimum damage to the host.

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If type I interferons are present early and properly localized to infection sites, they can limit viral propagation and support macrophage activation, dendritic cell antigen presentation and enhanced antiviral effector T cell responses.
“If type I IFNs are present early and properly localized to sites of infection, they can effectively limit viral propagation, as type I IFNs are responsible for optimal activation of macrophages, antigen presentation by DCs, and enhanced anti-viral effector T cell responses106.”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [106]

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Influenza A Virus Impairs Control of Mycobacterium tuberculosis Coinfection Through a Type I Interferon Receptor–Dependent Pathway
Redford, P. S., Mayer-Barber, K. D., McNab, F. W., Stavropoulos, E., Wack, A., Sher, A., & O’Garra, A. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit424 · Cited by 136 · see citing works
Self-citation
Legionella pneumophila Induces IFNβ in Lung Epithelial Cells via IPS-1 and IRF3, Which Also Control Bacterial Replication
Opitz, B., Vinzing, M., van Laak, V., Schmeck, B., Heine, G., Günther, S., Preißner, R., Slevogt, H., N’Guessan, P. D., Eitel, J., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604638200 · Cited by 135 · see citing works
Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes
Carrero, J. A., Calderón, B., & Unanue, E. R. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060045 · Cited by 135 · see citing works
Glucocorticoids drive human CD8+ T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production
Richards, D. F., Fernandez, M., Caulfield, J., & Hawrylowicz, C. M. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(2000)30:8 · Cited by 133 · see citing works
Expression of the Nitric Oxide Synthase 2 Gene Is Not Essential for Early Control ofMycobacterium tuberculosisin the Murine Lung
Cooper, A. M., Pearl, J. E., Brooks, J. V., Ehlers, S., & Orme, I. M. (2000) · Infection and Immunity · doi:10.1128/iai.68.12.6879-6882.2000 · Cited by 133 · see citing works
Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10
Kelly‐Scumpia, K. M., Scumpia, P. O., Delano, M. J., Weinstein, J. S., Cuenca, A. G., Wynn, J. L., & Moldawer, L. L. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091959 · Cited by 132 · see citing works
Potent Immune Response against HIV-1 and Protection from Virus Challenge in hu-PBL-SCID Mice Immunized with Inactivated Virus-pulsed Dendritic Cells Generated in the Presence of IFN-α
Lapenta, C., Santini, S. M., Logozzi, M., Spada, M., Andreotti, M., Pucchio, T. D., Parlato, S., & Belardelli, F. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021924 · Cited by 128 · see citing works
IFN-αβ-Dependent, IFN-γ Secretion by Bone Marrow-Derived Macrophages Controls an Intracellular Bacterial Infection
Rothfuchs, A. G., Gigliotti, D., Palmblad, K., Andersson, U., Wigzell, H., & Rottenberg, M. E. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6453 · Cited by 128 · see citing works
Type I IFNs Enhance Susceptibility to Chlamydia muridarum Lung Infection by Enhancing Apoptosis of Local Macrophages
Qiu, H., Fan, Y., Joyee, A. G., Wang, S., Han, X., Bai, H., Jiao, L., van Rooijen, N., & Yang, X. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.2092 · Cited by 123 · see citing works
Cutting Edge: Mycobacterium tuberculosis but Not Nonvirulent Mycobacteria Inhibits IFN-β and AIM2 Inflammasome–Dependent IL-1β Production via Its ESX-1 Secretion System
Shah, S., Bohsali, A., Ahlbrand, S. E., Srinivasan, L., Rathinam, V. A. K., Vogel, S. N., Fitzgerald, K. A., Sutterwala, F. S., & Briken, V. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301331 · Cited by 123 · see citing works
Cutting Edge: A Murine, IL-12-Independent Pathway of IFN-γ Induction by Gram-Negative Bacteria Based on STAT4 Activation by Type I IFN and IL-18 Signaling
Freudenberg, M. A., Merlin, T., Kalis, C., Chvatchko, Y., STÜBIG, H., & Galanos, C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1665 · Cited by 121 · see citing works
Interferon-α sensitizes human hepatoma cells to TRAIL-induced apoptosis through DR5 upregulation and NF-κB inactivation
Shigeno, M., Nakao, K., Ichikawa, T., Suzuki, K., Kawakami, A., Abiru, S., Miyazoe, S., Nakagawa, Y., Ishikawa, H., Hamasaki, K., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206139 · Cited by 117 · see citing works
Conventional Dendritic Cells Mount a Type I IFN Response against <i>Candida</i> spp. Requiring Novel Phagosomal TLR7-Mediated IFN-β Signaling
Bourgeois, C., Majer, O., Frohner, I. E., Lesiak-Markowicz, I., Hildering, K.-S., Glaser, W., Stockinger, S., Decker, T., Akira, S., Müller, M., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002599 · Cited by 116 · see citing works
Early type I interferon‐mediated signals on B cells specifically enhance antiviral humoral responses
Fink, K., Lang, K. S., Manjarrez‐Orduño, N., Junt, T., Senn, B. M., Holdener, M., Akira, S., Zinkernagel, R. M., & Hengartner, H. (2006) · European Journal of Immunology · doi:10.1002/eji.200635993 · Cited by 114 · see citing works
Viral Infection Augments Nod1/2 Signaling to Potentiate Lethality Associated with Secondary Bacterial Infections
Kim, Y., Park, J., Reimer, T., Baker, D. P., Kawai, T., Kumar, H., Akira, S., Wobus, C. E., & Núñez, G. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.05.006 · Cited by 113 · see citing works
Type I interferons suppress CD4+ T‐cell‐dependent parasite control during blood‐stage Plasmodium infection
Haque, A., Best, S. E., Ammerdorffer, A., Desbarrieres, L., de, M. M., Amante, F. H., Rivera, F. D. L., Hertzog, P. J., Boyle, G. M., Hill, G. R., et al. (2011) · European Journal of Immunology · doi:10.1002/eji.201141539 · Cited by 111 · see citing works
The Role of Host Genetics in Susceptibility to Influenza: A Systematic Review
Horby, P., Nguyen, N., Dunstan, S. J., & Baillie, J. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033180 · Cited by 111 · see citing works
Modulation of STAT1 protein levels: a mechanism shaping CD8 T-cell responses in vivo
Gil, M. P., Salomon, R., Louten, J., & Biron, C. A. (2005) · Blood · doi:10.1182/blood-2005-07-2834 · Cited by 110 · see citing works
Characterization of the Interferon-Producing Cell in Mice Infected with Listeria monocytogenes
Stockinger, S., Kastner, R., Kernbauer, E., Pilz, A., Westermayer, S., Reutterer, B., Soulat, D., Stengl, G., Vogl, C., Frenz, T., et al. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000355 · Cited by 109 · see citing works
A Temporal Role Of Type I Interferon Signaling in CD8+ T Cell Maturation during Acute West Nile Virus Infection
Pinto, A. K., Daffis, S., Brien, J. D., Gainey, M. D., Yokoyama, W. M., Sheehan, K. C. F., MURPHY, K. M. M., Schreiber, R. D., & Diamond, M. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002407 · Cited by 107 · see citing works
Alpha and Lambda Interferon Together Mediate Suppression of CD4 T Cells Induced by Respiratory Syncytial Virus
Chi, B., Dickensheets, H. L., Spann, K. M., Alston, M. A., Luongo, C., Dumoutier, L., Huang, J., Renauld, J., Kotenko, S. V., Roederer, M., et al. (2006) · Journal of Virology · doi:10.1128/jvi.80.10.5032-5040.2006 · Cited by 106 · see citing works
B7-1/2 (CD80/CD86) Direct Signaling to B Cells Enhances IgG Secretion
Rau, F. C., Dieter, J. A., Luo, Z., Priest, S. O., & Baumgarth, N. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803783 · Cited by 105 · see citing works
Beta Interferon Controls West Nile Virus Infection and Pathogenesis in Mice
Lazear, H. M., Pinto, A. K., Vogt, M. R., Gale, M., & Diamond, M. (2011) · Journal of Virology · doi:10.1128/jvi.00396-11 · Cited by 104 · see citing works
Differential Responses of Immune Cells to Type I Interferon Contribute to Host Resistance to Viral Infection
Baranek, T., Manh, T. V., Alexandre, Y. O., Maqbool, M. A., Cabeza, J. Z., Tomasello, E., Crozat, K., Bessou, G., Zucchini, N., Robbins, S. H., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.09.002 · Cited by 103 · see citing works
Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis
van Grevenynghe, J., Cubas, R. A., Noto, A., DaFonseca, S., He, Z., Peretz, Y., Filali-Mouhim, A., Dupuy, F. P., Procopio, F. A., Chomont, N., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59211 · Cited by 100 · see citing works
Signal 3 Cytokines as Modulators of Primary Immune Responses during Infections: The Interplay of Type I IFN and IL-12 in CD8 T Cell Responses
Keppler, S. J., Rosenits, K., Kögl, T., Vucikuja, S., & Aichele, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040865 · Cited by 99 · see citing works
TPL-2–ERK1/2 Signaling Promotes Host Resistance against Intracellular Bacterial Infection by Negative Regulation of Type I IFN Production
McNab, F. W., Ewbank, J., Rajsbaum, R., Stavropoulos, E., Մարտիրոսյան, Ա., Redford, P. S., Wu, X., Graham, C. M., Saraiva, M., Tsichlis, P. N., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300146 · Cited by 96 · see citing works
Self-citation
Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration
Tschurtschenthaler, M., Wang, J., Fricke, C., Fritz, T. M. J., Niederreiter, L., Adolph, T. E., Sarcevic, E., Künzel, S., Offner, F. A., Kalinke, U., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-305863 · Cited by 96 · see citing works
Resident bone marrow macrophages produce type 1 interferons that can selectively inhibit interleukin-7-driven growth of B lineage cells
Wang, J. O., Lin, Q., Langston, H. P., & Cooper, M. D. (1995) · Immunity · doi:10.1016/1074-7613(95)90176-0 · Cited by 94 · see citing works
Recognition of yeast nucleic acids triggers a host‐protective type I interferon response
Biondo, C., Signorino, G., Costa, A., Midiri, A., Gerace, E., Galbo, R., Bellantoni, A., Malara, A., Beninati, C., Teti, G., et al. (2011) · European Journal of Immunology · doi:10.1002/eji.201141490 · Cited by 93 · see citing works
Virus-Induced Transient Immune Suppression and the Inhibition of T Cell Proliferation by Type I Interferon
Marshall, H. D., Urban, S. L., & Welsh, R. M. (2011) · Journal of Virology · doi:10.1128/jvi.02516-10 · Cited by 93 · see citing works
Cutting Edge: IL-15-Independent NK Cell Response to Mouse Cytomegalovirus Infection
Sun, J. C.-Y., Ma, A., & Lanier, L. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901872 · Cited by 93 · see citing works
INTERFERON α AUGMENTS ACTIVATION-INDUCED T CELL DEATH BY UPREGULATION OF FAS (CD95/APO-1) AND FAS LIGAND EXPRESSION
Kaser, A., Nagata, S., & Tilg, H. (1999) · Cytokine · doi:10.1006/cyto.1998.0484 · Cited by 91 · see citing works
Type I IFN Receptor Regulates Neutrophil Functions and Innate Immunity to Leishmania Parasites
Xin, L., Vargas‐Inchaustegui, D. A., Raimer, S., Kelly, B. C., Hu, J., Zhu, L., Sun, J., & Soong, L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903273 · Cited by 91 · see citing works
Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function
Gil, M. P., Ploquin, M. J.-Y., Watford, W. T., Lee, S., Kim, K., Wang, X., Kanno, Y., O’Shea, J. J., & Biron, C. A. (2012) · Blood · doi:10.1182/blood-2012-05-428672 · Cited by 90 · see citing works
IFN-β Impairs Superoxide-Dependent Parasite Killing in Human Macrophages: Evidence for a Deleterious Role of SOD1 in Cutaneous Leishmaniasis
Khouri, R., Báfica, A. L. B., da Silva, M. D. P. P., Noronha, A., Kolb, J., Wietzerbin, J., Barral, A. M. P., Barral‐Netto, M., & Weyenbergh, J. V. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802860 · Cited by 88 · see citing works
Monocyte-Derived Dendritic Cells Generated After a Short-Term Culture with IFN-α and Granulocyte-Macrophage Colony-Stimulating Factor Stimulate a Potent Epstein-Barr Virus-Specific CD8+ T Cell Response
Santodonato, L., D’Agostino, G., Nisini, R., Mariotti, S., Monque, D. M., Spada, M., Lattanzi, L., Perrone, M. P., Andreotti, M., Belardelli, F., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.10.5195 · Cited by 86 · see citing works
TLR-Dependent Induction of IFN-β Mediates Host Defense against Trypanosoma cruzi
Koga, R., Hamano, S., Kuwata, H., Atarashi, K., Ogawa, M., Hisaeda, H., Yamamoto, M., Akira, S., Himeno, K., Matsumoto, M., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7059 · Cited by 86 · see citing works
Prostaglandin E2 Suppresses Lipopolysaccharide-Stimulated IFN-β Production
Xu, X. J., Reichner, J. S., Mastrofrancesco, B., Henry, W. L., & Albina, J. E. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2125 · Cited by 85 · see citing works
Type 1 Interferon Induction of Natural Killer Cell Gamma Interferon Production for Defense during Lymphocytic Choriomeningitis Virus Infection
Mack, E. A., Kallal, L. E., Demers, D. A., & Biron, C. A. (2011) · mBio · doi:10.1128/mbio.00169-11 · Cited by 84 · see citing works
MyD88 and STING Signaling Pathways Are Required for IRF3-Mediated IFN-β Induction in Response to Brucella abortus Infection
de Almeida, L. A., Carvalho, N. B., Oliveira, F. S., Lacerda, T. L. S., Vasconcelos, A. C., Nogueira, L. D. L., Báfica, A. L. B., Silva, A. M., & Oliveira, S. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023135 · Cited by 83 · see citing works
Classical CD11c+ dendritic cells, not plasmacytoid dendritic cells, induce T cell responses to Plasmodium chabaudi malaria
Voisine, C., Mastelic, B., Sponaas, A., & Langhorne, J. (2009) · International Journal for Parasitology · doi:10.1016/j.ijpara.2009.11.005 · Cited by 81 · see citing works
Early B-Cell Activation after West Nile Virus Infection Requires Alpha/Beta Interferon but Not Antigen Receptor Signaling
Purtha, W. E., Chachu, K. A., Virgin, H. W., & Diamond, M. (2008) · Journal of Virology · doi:10.1128/jvi.01646-08 · Cited by 81 · see citing works
Interferons Direct an Effective Innate Response to Legionella pneumophila Infection
Plumlee, C. R., Lee, C., Beg, A. A., Decker, T., Shuman, H. A., & Schindler, C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.018283 · Cited by 80 · see citing works
Type I IFN Protects Permissive Macrophages from Legionella pneumophila Infection through an IFN-γ-Independent Pathway
Schiavoni, G., Mauri, C., Carlei, D., Belardelli, F., Pastoris, M. C., & Proietti, E. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.1266 · Cited by 79 · see citing works
Recombinant Human IFN-α Inhibits Cerebral Malaria and Reduces Parasite Burden in Mice
Vigário, A. M., Belnoue, E., Grüner, A. C., Mauduit, M., Kayibanda, M., Deschemin, J., Marussig, M., Snounou, G., Mazier, D., Gresser, I., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6416 · Cited by 77 · see citing works
Reciprocal responsiveness to interleukin-12 and interferon-α specifies human CD8+ effector versus central memory T-cell fates
Ramos, H. J., Davis, A. M., Cole, A. G., Schatzle, J. D., Forman, J., & Farrar, J. D. (2009) · Blood · doi:10.1182/blood-2008-11-188458 · Cited by 75 · see citing works
Poly I:C Enhances Susceptibility to Secondary Pulmonary Infections by Gram-Positive Bacteria
Tian, X., Xu, F., Lung, W. Y., Meyerson, C., Ghaffari, A. A., Cheng, G., & Deng, J. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041879 · Cited by 75 · see citing works
Local Blockade of Epithelial PDL-1 in the Airways Enhances T Cell Function and Viral Clearance during Influenza Virus Infection
McNally, B. A., Ye, F., Willette, M., & Flaño, E. (2013) · Journal of Virology · doi:10.1128/jvi.02423-13 · Cited by 72 · see citing works
Activation Mechanisms of Natural Killer Cells during Influenza Virus Infection
Hwang, I., Scott, J. M., Kakarla, T., Duriancik, D. M., Choi, S., Cho, C., Lee, T., Park, H., French, A. R., Beli, E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051858 · Cited by 72 · see citing works
Natural and recombinant interferons inhibit epithelial cell invasion by Shigella spp
Niesel, D. W., Hess, C. B., Cho, Y. J., Klimpel, K. D., & Klimpel, G. R. (1986) · Infection and Immunity · doi:10.1128/iai.52.3.828-833.1986 · Cited by 70 · see citing works

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Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
Immunogenic cell death in cancer and infectious disease
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119 · see citing works
CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer
McLane, L. M., Abdel-Hakeem, M. S., & Wherry, E. J. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055318 · Cited by 1,973 · see citing works
RIG-I-like receptors: their regulation and roles in RNA sensing
Rehwinkel, J., & Gack, M. U. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0288-3 · Cited by 1,703 · see citing works
Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice
Channappanavar, R., Fehr, A. R., Vijay, R., Mack, M., Zhao, J., Meyerholz, D. K., & Perlman, S. M. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.01.007 · Cited by 1,400 · see citing works
Type I interferons in anticancer immunity
Zitvogel, L., Galluzzi, L., Kepp, O., Smyth, M. J., & Kroemer, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3845 · Cited by 1,305 · see citing works
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
Galluzzi, L., Vitale, I., Warren, S., Adjemian, S., Agostinis, P., Buqué, A., Chan, T. A.-T., Coukos, G., Demaria, S., Deutsch, É., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000337 · Cited by 1,151 · see citing works
Detection of immunogenic cell death and its relevance for cancer therapy
Fucikova, J., Kepp, O., Kasikova, L., Petroni, G., Yamazaki, T., Liu, P., Zhao, L., Spisek, R., Kroemer, G., & Galluzzi, L. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-03221-2 · Cited by 1,138 · see citing works
Mitochondrial DNA in innate immune responses and inflammatory pathology
West, A. P., & Shadel, G. S. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.21 · Cited by 1,115 · see citing works
IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation
Ouyang, W., & O’Garra, A. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.020 · Cited by 1,084 · see citing works
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The senescence-associated secretory phenotype and its physiological and pathological implications
Wang, B., Han, J., Elisseeff, J. H., & Demaria, M. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00727-x · Cited by 948 · see citing works
Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses
Qi, F., Qian, S., Zhang, S., & Zhang, Z. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.03.044 · Cited by 905 · see citing works
Autophagy in inflammation, infection, and immunometabolism
Deretic, V. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.018 · Cited by 862 · see citing works
Control of Metastasis by NK Cells
López‐Soto, A., Gonzalez, S. R., Smyth, M. J., & Galluzzi, L. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.06.009 · Cited by 730 · see citing works
Therapeutic strategies for COVID-19: progress and lessons learned
Li, G., Hilgenfeld, R., Whitley, R. J., & Clercq, E. D. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00672-y · Cited by 691 · see citing works
The dual nature of type I and type II interferons
Lee, A. J., & Ashkar, A. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02061 · Cited by 690 · see citing works
The Role of Astrocytes in CNS Inflammation
Giovannoni, F., & Quintana, F. J. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.007 · Cited by 651 · see citing works
The hallmarks of successful anticancer immunotherapy
Galluzzi, L., Chan, T. A., Kroemer, G., Wolchok, J. D., & López-Soto, A. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat7807 · Cited by 575 · see citing works
Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease
Roy, E. R., Wang, B., Wan, Y.-W., Chiu, G., Cole, A., Yin, Z., Propson, N. E., Xu, Y., Jankowsky, J. L., Liu, Z., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133737 · Cited by 563 · see citing works
Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny
Huang, L., Nazarova, E. V., Tan, S., Liu, Y., & Russell, D. G. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172020 · Cited by 550 · see citing works
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison
Galani, I.-E., Rovina, N., Lampropoulou, V., Triantafyllia, V., Manioudaki, M., Pavlos, E., Koukaki, E., Fragkou, P. C., Panou, V., Rapti, V., et al. (2021) · Nature Immunology · doi:10.1038/s41590-020-00840-x · Cited by 503 · see citing works
LINE1 Derepression in aged wild-type and SIRT6-deficient mice drives inflammation
Simon, M., Van Meter, M., Ablaeva, J., Ke, Z., Gonzalez, R. S., Taguchi, T., De Cecco, M., Leonova, K. I., Kogan, V., Helfand, S. L., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.02.014 · Cited by 498 · see citing works
TORC1 inhibition enhances immune function and reduces infections in the elderly
Mannick, J. B., Morris, M., Hockey, H.-U. P., Roma, G., Beibel, M., Kulmatycki, K., Watkins, M., Shavlakadze, T., Zhou, W., Quinn, D., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aaq1564 · Cited by 496 · see citing works
Type I and III interferons disrupt lung epithelial repair during recovery from viral infection
Major, J., Crotta, S., Llorian, M., McCabe, T. M., Gad, H. H., Priestnall, S. L., Hartmann, R., & Wack, A. (2020) · Science · doi:10.1126/science.abc2061 · Cited by 488 · see citing works
Self-citation
Ubiquitin signaling in immune responses
Hu, H., & Sun, S. (2016) · Cell Research · doi:10.1038/cr.2016.40 · Cited by 481 · see citing works
Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
Lee, Y., Jeong, M., Park, J., Jung, H., & Lee, H. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01086-x · Cited by 477 · see citing works
Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness
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Authors: McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A.
Affiliations: GlaxoSmithKline (United Kingdom) (GB)
National Institutes of Health (US)
National Institute for Medical Research (GB)
ORCID: Mayer-Barber, Katrin
Sher, Alan
Wack, Andreas
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2015-01-23
Volume: 15
Issue: 2
Pages: 87-103
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3787
PMC: PMC7162685
OpenAlex: W2091129202
Cited by: 2,780
References: 238
Citations by year: 2026: 263 · 2025: 333 · 2024: 364 · 2023: 330 · 2022: 330 · 2021: 307 · 2020: 194 · 2019: 160 · 2018: 166 · 2017: 169 · 2016: 119 · 2015: 44 · 2013: 1
FWCI: 15.67
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Wellcome Trust (FC001126)
Francis Crick Institute (10206, 10126)
Cancer Research UK (FC001126)
National Institutes of Health
Medical Research Council (U117597139, U117565642)
National Institute of Allergy and Infectious Diseases
FP7 Ideas: European Research Council (294682)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords: type I interferon, innate immunity, viral infection, bacterial infection, parasitic infection, fungal infection, immunopathology, influenza virus, lymphocytic choriomeningitis virus, chronic viral infection, immunosuppression, B cell response, macrophage activation, Listeria monocytogenes, Mycobacterium tuberculosis, prostaglandin E2, interleukin-1, host defense
MeSH terms: Animals, Bacterial Infections, Communicable Diseases, Humans, Interferon Type I, Mycoses, Parasitic Diseases, Virus Diseases, Signal Transduction

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