The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Heterogeneity of rat liver and spleen macrophages in gadolinium chloride–induced elimination and repopulation
Abstract
Blockade of phagocytosis and selective elimination of macrophages (mφs) are generally accepted procedures for gaining knowledge about the function of mφs in vivo. This study demonstrates that intravenous injection of gadolinium chloride (GdCl3) not only blocks phagocytosis by rat liver mφs (Kupffer cells) but also selectively eliminates the large mφs situated in the periportal zone of the liver acinus. Repopulation of mφs starts at 4 days after injection. During repopulation, mφs are less vulnerable to GdCl3. When repopulation is complete, the new mφs show the same vulnerability as the original ones. Splenic mφs are less vulnerable to GdCl3 because only some of the red pulp mφs transiently disappear. The white pulp mφs are not affected. Repopulation occurs sooner than in liver. These results indicate that administration of GdCl3 is a suitable approach to studying the in vivo function of large Kupffer cells.
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Cites
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
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Metadata
- Authors
- Hardonk, M., Dijkhuis, F., Hulstaert, C., & Koudstaal, J.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-09-01
- Volume
- 52
- Issue
- 3
- Pages
- 296-302
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2169940712
- Cited by
- 358
- References
- 1
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hardonk, M., Dijkhuis, F., Hulstaert, C., & Koudstaal, J. (1992). Heterogeneity of rat liver and spleen macrophages in gadolinium chloride–induced elimination and repopulation. Journal of Leukocyte Biology. https://doi.org/10.1002/jlb.52.3.296
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
