Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

Huang, Wan; Metlakunta, Anantha; Dedousis, Nikolaos; Zhang, Pili; Sipula, Ian; Dube, John J.; Scott, Donald K.; O'Doherty, Robert M.

doi:10.2337/db09-0016

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

OBJECTIVE Increased activity of the innate immune system has been implicated in the pathogenesis of the dyslipidemia and insulin resistance associated with obesity and type 2 diabetes. In this study, we addressed the potential role of Kupffer cells (liver-specific macrophages, KCs) in these metab…