The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Human monocytes/macrophages: NO or no NO?
Abstract
The production of nitric oxide (NO) and other reactive nitrogen intermediates by cytokine-activated rodent cells is an important component of antimicrobial and/or antineoplasic activity of these cells. This pathway involves the oxidation of arginine to citrulline, with the concomitant release of NO by an inducible form of NO synthase (iNOS). Numerous cell types express iNOS after stimulation with bacterial products and/or cytokines. The role of NO and its derivatives in host resistance is a subject of intense investigation in mouse models of infections or neoplasia. Although human cells such as hepatocytes and endothelial cells have been shown to express an inducible NO synthase, the presence of such a pathway in human monocytes/macrophages has been questioned by many investigators and is a subject of great controversy. In this short review, we discuss some salient points of this debate. J. Leukoc. Biol. 55: 682–684; 1994.
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Hibbs, J. B., Westenfelder, C., Taintor, R., Vavrin, Z., Kablitz, C., Baranowski, R. L., Ward, J. H., Menlove, R. L., McMurry, M. P., & Kushner, J. P. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115666 · Cited by 485
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“For example, murine neutrophils lack defensins (30), a class of cationic antimicrobial peptides, but appear to have a higher capacity to generate nitric oxide ( 31 ).”
Background
Metadata
- Authors
- Denis, M.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-05-01
- Volume
- 55
- Issue
- 5
- Pages
- 682-684
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2169140191
- Cited by
- 274
- References
- 1
- FWCI
- 18.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Denis, M. (1994). Human monocytes/macrophages: NO or no NO? Journal of Leukocyte Biology. https://doi.org/10.1002/jlb.55.5.682
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
