The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The high-output nitric oxide pathway: role and regulation
Abstract
Nitric oxide synthase (NOS) catalyzes the production of nitric oxide (NO), a short-lived radical gas with physiological or pathophysiological roles in nearly every organ system. The inducible NO synthase (iNOS) is a high-output isoform compared to the two constitutive NOSs. The iNOS from murine macrophages tightly binds calmodulin as a subunit, and its activity is not dependent on exogenous calmodulin or elevated calcium. This iNOS is induced at the transcriptional level by bacterial lipopolysaccharide (LPS) and interferon-γ. The promoter region of the murine iNOS gene contains at least 24 oligonucleotide motifs corresponding to elements involved in the binding of transcription factors in the promoters of other cytokine-inducible genes. Nuclear factor NF-xB/c-rel, interacting with cycloheximide-sensitive protein(s) and binding to the NF-xBd site in the iNOS promoter, controls the induction of iNOS by LPS. However, iNOS is also regulated posttranscriptionally. Complex regulation of iNOS at multiple levels may reflect the dual role of iNOS in host defense and autotoxicity. J. Leukoc. Biol. 56: 576–582; 1994.
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The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.
Xie, Q. W., Kashiwabara, Y., & Nathan, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37600-7 · Cited by 2,212 · cited 7×
“II, and X is NF-xBd dependent. In both RAW cells [ 45 ] and”
BackgroundMethodInfluentialSelf-citationDithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.
Schreck, R., Meier, B., Männel, D. N., Dröge, W., & Baeuerle, P. A. (1992) · The Journal of experimental medicine · doi:10.1084/jem.175.5.1181 · Cited by 1,508
Baek, K. J., Thiel, B. A., Lucas, S., & Stuehr, D. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36901-7 · Cited by 389
Translational regulation via iron‐responsive elements by the nitric oxide/NO‐synthase pathway.
Weiss, G., Goossen, B., Doppler, W., Fuchs, D., Pantopoulos, K., Werner‐Felmayer, G., Wachter, H., & Hentze, M. W. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06039.x · Cited by 389
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Lundberg, J. O., Weitzberg, E., Cole, J. A., & Benjamin, N. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro929 · Cited by 739
Biosynthesis and action of nitric oxide in mammalian cells
Mayer, B., & Hemmens, B. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01147-x · Cited by 600
Nitric oxide and wound repair: role of cytokines?
Schwentker, A., Vodovotz, Y., Weller, R., & Billiar, T. R. (2002) · Nitric Oxide · doi:10.1016/s1089-8603(02)00002-2 · Cited by 386
Long-term cerebral consequences of sepsis
Widmann, C. N., & Heneka, M. T. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70017-1 · Cited by 361
Melatonin is a scavenger of peroxynitrite
Gilad, E., Cuzzocrea, S., Zingarelli, B., Salzman, A. L., & Szabó, C. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00008-8 · Cited by 317
Metadata
- Authors
- Xie, Q.-W., & Nathan, C.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-11-01
- Volume
- 56
- Issue
- 5
- Pages
- 576-582
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2101392591
- Cited by
- 510
- References
- 5
- FWCI
- 16.87
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
