Nitric oxide and wound repair: role of cytokines?
Abstract
Wound healing involves platelets, inflammatory cells, fibroblasts, and epithelial cells. All of these cell types are capable of producing nitric oxide (NO), either constitutively or in response to inflammatory cytokines, through the activity of nitric oxide synthases (NOSs): eNOS (NOS3; endothelial NOS) and iNOS (NOS2; inducible NOS), respectively. Indeed, pharmacological inhibition or gene deletion of these enzymes impairs wound healing. The wound healing mechanisms that are triggered by NO appear to be diverse, involving inflammation, angiogenesis, and cell proliferation. All of these processes are controlled by defined cytokine cascades; in many cases, NO appears to modulate these cytokines. In this review, we summarize the history and present state of research on the role of NO in wound healing within the framework of modulation of cytokines.
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Nitric oxide is believed to control inflammatory cell recruitment in the early stages of the foreign body response.
“NO is also believed to control inflammatory cell recruitment in the early stages of the FBR.215”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [215]
Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525 · see citing works
Nitric oxide as a secretory product of mammalian cells
Nathan, C. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.12.1381691 · Cited by 4,350 · see citing works
NITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,184 · see citing works
Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U., Liotta, L. A., Falanga, V., & Kehrl, J. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4167 · Cited by 2,867 · see citing works
Caterina, R. D., Libby, P., Peng, H., Thannickal, V. J., Rajavashisth, T. B., Gimbrone, M. A., Shin, W. S., & Liao, J. K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118074 · Cited by 1,781 · see citing works
Opal, S. M., & DePalo, V. A. (2000) · Chest · doi:10.1378/chest.117.4.1162 · Cited by 1,752 · see citing works
Regulation of biosynthesis of nitric oxide.
Nathan, C., & Xie, Q. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36703-0 · Cited by 1,669 · see citing works
The Molecular and Cellular Biology of Wound Repair
Clark, R. A. F., & Henson, P. M. (1988) · Springer eBooks · doi:10.1007/978-1-4615-1795-5 · Cited by 1,524 · see citing works
Role of nitric oxide synthesis in macrophage antimicrobial activity
Nathan, C. F., & Hibbs, J. B. (1991) · Current Opinion in Immunology · doi:10.1016/0952-7915(91)90079-g · Cited by 1,523 · see citing works
Biosynthesis And Metabolism Of Endothelium-Derived Nitric Oxide
Ignarro, L. J. (1990) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.30.040190.002535 · Cited by 1,300 · see citing works
Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.
Wahl, S. M., Hunt, D. A., Wakefield, L. M., McCartney-Francis, N. L., Wahl, L. M., Roberts, A. B., & Sporn, M. B. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5788 · Cited by 1,273 · see citing works
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
Murohara, T., Asahara, T., Silver, M., Bauters, C., Masuda, H., Kalka, C., Kearney, M., Chen, D., Symes, J. F., Fishman, M. C., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1560 · Cited by 1,201 · see citing works
Papapetropoulos, A., García‐Cardeña, G., Madri, J. A., & Sessa, W. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119868 · Cited by 1,192 · see citing works
Ziche, M., Morbidelli, L., Choudhuri, R., Zhang, H. T., Donnini, S., Granger, H. J., & Bicknell, R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119451 · Cited by 914 · see citing works
Brown, L. F., Yeo, K. T., Berse, B., Yeo, T. K., Senger, D. R., Dvorak, H. F., & van de Water, L. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.5.1375 · Cited by 878 · see citing works
Ziche, M., Morbidelli, L., Masini, E., Amerini, S., Granger, H. J., Maggi, C. A., Geppetti, P., & Ledda, F. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117557 · Cited by 861 · see citing works
Angiogenesis: regulators and clinical applications
Liekens, S., De Clercq, E., & Neyts, J. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00529-3 · Cited by 748 · see citing works
Transforming Growth Factor‐β: Major Role in Regulation of Extracellular Matrix
ROBERTS, A. B., HEINE, U. I., FLANDERS, K. C., & SPORN, M. B. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb17931.x · Cited by 696 · see citing works
VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
Hood, J. D., Meininger, C. J., Ziche, M., & Granger, H. J. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.3.h1054 · Cited by 696 · see citing works
The molecular and cellular biology of wound repair
Naylor, I. L. (1996) · British Journal of Plastic Surgery · doi:10.1016/s0007-1226(96)90047-8 · Cited by 668 · see citing works
The role of nitric oxide in innate immunity
Bogdan, C., Röllinghoff, M., & Diefenbach, A. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.917307.x · Cited by 665 · see citing works
Zachary, I. C. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00268-6 · Cited by 659 · see citing works
Growth factors: importance in wound healing and maintenance of transparency of the cornea
Imanishi, J., Kamiyama, K., Iguchi, I., Kita, M., Sotozono, C., & Kinoshita, S. (2000) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(99)00007-5 · Cited by 534 · see citing works
The high-output nitric oxide pathway: role and regulation
Xie, Q. W., & Nathan, C. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.56.5.576 · Cited by 512 · see citing works
The Nitric Oxide Synthase Family of Proteins
Sessa, W. C. (2008) · Journal of Vascular Research · doi:10.1159/000159039 · Cited by 458 · see citing works
Arginine enhances wound healing and lymphocyte immune responses in humans.
Barbul, A., Lazarou, S. A., Efron, D. T., Wasserkrug, H. L., & Efron, G. (1990) · PubMed · Cited by 438 · see citing works
Yamasaki, K., Edington, H. D. J., McClosky, C., Tzeng, E., Lizonová, A., Kovesdi, I., Steed, D. L., & Billiar, T. R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2067 · Cited by 434 · see citing works
Self-citationParenti, A., Morbidelli, L., Cui, X.-L., Douglas, J. G., Hood, J. D., Granger, H. J., Ledda, F., & Ziche, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.4220 · Cited by 434 · see citing works
Tissue injury caused by deposition of immune complexes is L-arginine dependent.
Mulligan, M. S., Hevel, J. M., Marletta, M. A., & Ward, P. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.14.6338 · Cited by 422 · see citing works
Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium
Morbidelli, L., Chang, C.-H., Douglas, J. G., Granger, H. J., Ledda, F., & Ziche, M. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.1.h411 · Cited by 417 · see citing works
van der Zee, R., Murohara, T., Luo, Z., Zollmann, F. S., Passeri, J. J., Lekutat, C., & Isner, J. M. (1997) · Circulation · doi:10.1161/01.cir.95.4.1030 · Cited by 399 · see citing works
Pietenpol, J. A., Holt, J. T., Stein, R. W., & Moses, H. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3758 · Cited by 397 · see citing works
Ziche, M., & Morbidelli, L. (2000) · Journal of Neuro-Oncology · doi:10.1023/a:1006431309841 · Cited by 391 · see citing works
Li, H. Z., Meininger, C. J., Hawker, J. R., Haynes, T. E., Kepka‐Lenhart, D., Mistry, S. K., Morris, S. M., & Wu, G. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.1.e75 · Cited by 389 · see citing works
Impaired wound healing and angiogenesis in eNOS-deficient mice
Lee, P. C., Salyapongse, A. N., Bragdon, G. A., Shears, L. L., Watkins, S. C., Edington, H. D. J., & Billiar, T. R. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.4.h1600 · Cited by 369 · see citing works
Self-citationReciprocal relation between VEGF and NO in the regulation of endothelial integrity
Tsurumi, Y., Murohara, T., Krasinski, K. L., Chen, D., Witzenbichler, B., Kearney, M., Couffinhal, T., & Isner, J. M. (1997) · Nature Medicine · doi:10.1038/nm0897-879 · Cited by 356 · see citing works
Thiemermann, C., Szabó, C., Mitchell, J. A., & Vane, J. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.267 · Cited by 352 · see citing works
Temporal expression of different pathways of 1-arginine metabolism in healing wounds.
Albina, J. E., Mills, C. D., Henry, W. L., & Caldwell, M. D. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.10.3877 · Cited by 351 · see citing works
Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds
Lander, H. M., Sehajpal, P. K., Levine, D. M., & Novogrodsky, A. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.4.1509 · Cited by 340 · see citing works
Coffey, R. J., Bascom, C. C., Sipes, N. J., Graves‐Deal, R., Weissman, B. E., & Moses, H. L. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.8.3088 · Cited by 320 · see citing works
Molecular mechanisms of UV-induced apoptosis
Kulms, D., & Schwarz, T. (2000) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1034/j.1600-0781.2000.160501.x · Cited by 319 · see citing works
Characterization of the l ‐arginine: nitric oxide pathway in human platelets
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb12709.x · Cited by 312 · see citing works
Arginine stimulates wound healing and immune function in elderly human beings.
Kirk, S., Hurson, M., Regan, M., Holt, D. R., Wasserkrug, H. L., & Barbul, A. (1993) · PubMed · Cited by 310 · see citing works
Production of Vascular Endothelial Growth Factor by Murine Macrophages
Xiong, M., Elson, G., Legarda, D., & Leibovich, S. J. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65601-5 · Cited by 306 · see citing works
Bioactive Interleukin-8 Is Expressed in Wounds and Enhances Wound Healing
Rennekampff, H., Hansbrough, J. F., Kiessig, V., Doré, C., Sticherling, M., & Schröder, J. (2000) · Journal of Surgical Research · doi:10.1006/jsre.2000.5892 · Cited by 301 · see citing works
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.
Werner‐Felmayer, G., Werner, E. R., Fuchs, D., Hausen, A., Reibnegger, G. J., & WACHTER, H. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1599 · Cited by 287 · see citing works
Nitric Oxide Regulates Wound Healing
Schäffer, M. R., Tantry, U. S., Gross, S. S., Wasserkrug, H. L., & Barbul, A. (1996) · Journal of Surgical Research · doi:10.1006/jsre.1996.0254 · Cited by 279 · see citing works
Heck, D. E., Laskin, D. L., Gardner, C. R., & Laskin, D. L. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36601-3 · Cited by 278 · see citing works
Nitric oxide, an autocrine regulator of wound fibroblast synthetic function
Schäffer, M. R., Efron, P. A., Thornton, F. J., Klingel, K., Gross, S. S., & Barbul, A. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.5.2375 · Cited by 260 · see citing works
Arginine: an essential amino acid for injured rats.
SEIFTER, E. J., Rettura, G., Barbul, A., & Levenson, S. Μ. (1978) · PubMed · Cited by 245 · see citing works
VEGF induces NO-dependent hyperpermeability in coronary venules
Wu, H. M., Huang, Q., Yuan, Y., & Granger, H. J. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.6.h2735 · Cited by 243 · see citing works
Stallmeyer, B., Kämpfer, H., Kolb, N., Pfeilschifter, J. M., & Frank, S. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00784.x · Cited by 237 · see citing works
Frank, S., Stallmeyer, B., Kämpfer, H., Kolb, N., & Pfeilschifter, J. M. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.14.2002 · Cited by 232 · see citing works
Wiseman, D. M., Polverini, P. J., Kamp, D. W., & Leibovich, S. J. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80319-x · Cited by 232 · see citing works
Schäffer, M. R., Tantry, U. S., Efron, P. A., Ahrendt, G. M., Thornton, F. J., & Barbul, A. (1997) · Surgery · doi:10.1016/s0039-6060(97)90105-7 · Cited by 227 · see citing works
Interleukin-8 Stimulates Calcium Transients and Promotes Epidermal Cell Proliferation
Tuschil, A. F., Lam, C., Haslberger, A. G., & Lindley, I. J. D. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12616634 · Cited by 224 · see citing works
Reibman, J., Meixler, S., Lee, T. C., Gold, L. I., Cronstein, B. N., HAINES, K. A., Kolasinski, S. L., & Weissmann, G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.15.6805 · Cited by 218 · see citing works
Krischel, V., Bruch‐Gerharz, D., Suschek, C. V., Kröncke, K., Ruzicka, T., & Kolb-Bachofen, V. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00268.x · Cited by 210 · see citing works
Leibovich, S. J., Polverini, P. J., Fong, T., Harlow, L. A., & Koch, A. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4190 · Cited by 195 · see citing works
Calmodulin-independent nitric oxide synthase from rat polymorphonuclear neutrophils
Yui, Y., Hattori, R., Kosuga, K., Eizawa, H., Hiki, K., Ohkawa, S., Ohnishi, K., Terao, S., & Kawai, C. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67800-2 · Cited by 190 · see citing works
Role of growth factors in inflammation and repair
Wahl, S. M., Wong, H., & McCartney-Francis, N. L. (1989) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240400208 · Cited by 188 · see citing works
Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers
Konturek, S. J., Brzozowski, T., Majka, J., Pytko-Polończyk, J., & Stachura, J. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90997-v · Cited by 185 · see citing works
Kim, Y., Talanian, R. V., Li, J., & Billiar, T. R. (1998) · PubMed · Cited by 181 · see citing works
Self-citationPodokinesis in endothelial cell migration: role of nitric oxide
Noiri, E., Lee, E., Testa, J. E., Quigley, J. P., Colflesh, D. E., Keese, C. R., Giæver, I., & Goligorsky, M. S. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.1.c236 · Cited by 181 · see citing works
Shizukuda, Y., Tang, S., Yokota, R., & Ware, J. A. (1999) · Circulation Research · doi:10.1161/01.res.85.3.247 · Cited by 174 · see citing works
Histamine increases venular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade
Yuan, Y., Granger, H. J., Zawieja, D. C., DeFily, D. V., & Chilian, W. M. (1993) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1993.264.5.h1734 · Cited by 173 · see citing works
Nitric oxide modulation of human leukemia cell differentiation and gene expression
Magrinat, G., Mason, S. N., Shami, P., & Weinberg, J. (1992) · Blood · doi:10.1182/blood.v80.8.1880.1880 · Cited by 170 · see citing works
Kim, Y., Talanian, R. V., Li, J., & Billiar, T. R. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.8.4122 · Cited by 168 · see citing works
Self-citationWang, R., Ghahary, A., Shen, Y. J., Scott, P. G., & Tredget, E. E. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12343428 · Cited by 167 · see citing works
Clark, R. S. B., Kochanek, P. M., Schwarz, M. A., Schiding, J. K., Turner, D. S., Chen, M., Carlos, T. M., & Watkins, S. C. (1996) · Pediatric Research · doi:10.1203/00006450-199605000-00007 · Cited by 164 · see citing works
Shi, H., Efron, D. T., Most, D., Tantry, U. S., & Barbul, A. (2000) · Surgery · doi:10.1067/msy.2000.107372 · Cited by 163 · see citing works
Interactions of the Skin and Nervous System
Ansel, J. C., Armstrong, C. A., Song, I., Quinlan, K. L., Olerud, J. E., Caughman, S. W., & Bunnett, N. W. (1997) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.1997.6 · Cited by 159 · see citing works
Permissive Role of Nitric Oxide in Endothelin-induced Migration of Endothelial Cells
Noiri, E., Hu, Y., Bahou, W. F., Keese, C. R., Giæver, I., & Goligorsky, M. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.3.1747 · Cited by 157 · see citing works
Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis
Tzeng, E., Kim, Y.-M., Pitt, B. R., Lizonová, A., Kovesdi, I., & Billiar, T. R. (1997) · Surgery · doi:10.1016/s0039-6060(97)90016-7 · Cited by 153 · see citing works
Self-citationThornton, F. J., Schäffer, M. R., Witte, M. B., Moldawer, L. L., MacKay, S. L. D., Abouhamze, A. S., Tannahill, C. L., & Barbul, A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8681 · Cited by 146 · see citing works
Regulation of cytokine gene expression by reactive oxygen and reactive nitrogen intermediates
Remick, D. G., & Villarete, L. H. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.59.4.471 · Cited by 145 · see citing works
Nitric oxide up‐regulates the release of inflammatory mediators by mouse macrophages
Marcinkiewicz, J., Grabowska, A. K., & Chain, B. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250414 · Cited by 142 · see citing works
Regulation of transforming growth factor beta1 by nitric oxide.
Yoram Vodovotz, B., Chesler, L., Chong, H., Kim, S. J., Simpson, J. T., DeGraff, W., Cox, G. W., Roberts, A. B., Wink, D. A., & Barcellos‐Hoff, M. H. (1999) · PubMed · Cited by 139 · see citing works
Nitric Oxide Inhibition of Transforming Growth Factor-β and Collagen Synthesis in Mesangial Cells
Craven, P. A., Studer, R. K., Felder, J., Phillips, S. L., & DeRubertis, F. R. (1997) · Diabetes · doi:10.2337/diab.46.4.671 · Cited by 137 · see citing works
Schäffer, U. T. M. R. (1999) · The European Journal of Surgery · doi:10.1080/110241599750007153 · Cited by 135 · see citing works
Rao, K. M. K., Padmanabhan, J., Dl, K., Cohen, H. J., Currie, M. S., & Weinberg, J. B. (1992) · Journal of Leukocyte Biology · doi:10.1002/jlb.51.5.496 · Cited by 133 · see citing works
Jude, E. B., Boulton, A. J. M., Ferguson, M. W. J., & Appleton, I. (1999) · Diabetologia · doi:10.1007/s001250051224 · Cited by 132 · see citing works
Ziche, M., Morbidelli, L., Masini, E., Granger, H. J., Geppetti, P., & Ledda, F. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1543 · Cited by 126 · see citing works
Enhancement of Fibroblast Collagen Synthesis by Nitric Oxide
Witte, M. B., Thornton, F. J., Efron, D. T., & Barbul, A. (2000) · Nitric Oxide · doi:10.1006/niox.2000.0307 · Cited by 122 · see citing works
Papapetropoulos, A., Desai, K. M., Rudic, R. D., Mayer, B., Zhang, R., Ruiz‐Torres, M. P., García‐Cardeña, G., Madri, J. A., & Sessa, W. C. (1997) · Europe PMC (PubMed Central) · Cited by 119 · see citing works
Wound collagen deposition in rats: effects of an NO‐NSAID and a selective COX‐2 inhibitor
Muscará, M. N., McKnight, W., Asfaha, S., & Wallace, J. L. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703112 · Cited by 119 · see citing works
Deliconstantinos, G., Villiotou, V., & Stravrides, J. C. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb13341.x · Cited by 116 · see citing works
Kuhn, A., Fehsel, K., Lehmann, P. M., Krutmann, J., Ruzicka, T., & Kolb-Bachofen, V. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00253.x · Cited by 115 · see citing works
Frank, S., Pfeilschifter, J. M., Madlener, M., & Werner, S. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00434.x · Cited by 114 · see citing works
Glucocorticoid-regulated gene expression during cutaneous wound repair
BEER, H.-D., Fässler, R., & Werner, S. (2000) · Vitamins & Hormones · doi:10.1016/s0083-6729(00)59008-6 · Cited by 113 · see citing works
Reactive Oxygen Species in Biological Systems: An Interdisciplinary Approach
Kennedy, J. F., & Knill, C. J. (2001) · Carbohydrate Polymers · doi:10.1016/s0144-8617(01)00197-7 · Cited by 113 · see citing works
Yoram Vodovotz, B., Geiser, A. G., Chesler, L., Letterio, J. J., Campbell, A., Lucia, M. S., Sporn, M. B., & Roberts, A. B. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.5.2337 · Cited by 112 · see citing works
Activation of Latent Transforming Growth Factor ß
Flaumenhaft, R. C., Kojima, S., Abé, M., & Rifkin, D. B. (1993) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60933-3 · Cited by 111 · see citing works
Shimizu, Y., Sakai, M., Umemura, Y., & Ueda, H. (1997) · The Journal of Dermatology · doi:10.1111/j.1346-8138.1997.tb02748.x · Cited by 111 · see citing works
Endothelial nitric oxide synthase modulates gastric ulcer healing in rats
Ma, L., & Wallace, J. L. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.2.g341 · Cited by 110 · see citing works
Nitric Oxide Metabolism in Wounds
Schäffer, M. R., Tantry, U. S., Wesep, R. A. V., & Barbul, A. (1997) · Journal of Surgical Research · doi:10.1006/jsre.1997.5137 · Cited by 109 · see citing works
Reactive Oxygen Species in Biological Systems: An Interdisciplinary Approach
Daniel, L. G., & Colton, C. A. (2013) · Cited by 108 · see citing works
Deakin, A. M., Payne, A. N., Whittle, B. J. R., & Moncada, S. (1995) · Cytokine · doi:10.1006/cyto.1995.0056 · Cited by 108 · see citing works
Eigler, A., Moeller, J., & Endres, S. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.8.4048 · Cited by 106 · see citing works
Yoram Vodovotz, B. (1997) · Nitric Oxide · doi:10.1006/niox.1996.0105 · Cited by 104 · see citing works
IL-8/IL-8 receptor expression in psoriasis and the response to systemic tacrolimus (FK506) therapy
Lemster, B. H., Carroll, P. B., Rilo, H., Johnson, N., Nikaein, A., & Thomson, A. W. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb05525.x · Cited by 103 · see citing works
The Chemical Biology of Nitric Oxide
Wink, D. A., Feelisch, M., Yoram Vodovotz, B., Fukuto, J. M., & Grisham, M. B. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-46806-9_10 · Cited by 102 · see citing works
Chen, L., & Mehta, J. L. (1996) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199601000-00024 · Cited by 100 · see citing works
Retreatment Tuberculosis Cases
Kritski, A. L., de Jesus, L. S. R., Werneck-Barroso, E., Vieira, M. A. M. S., Andrade, M. K. D. N., de Jesus, L. S. R., Werneck-Barroso, E., Vieira, M. A. M. S., Andrade, M. K. D. N., Haffner, A., et al. (1997) · CHEST Journal · doi:10.1378/chest.111.5.1162 · Cited by 97 · see citing works
Reichner, J. S., Meszaros, A. J., Louis, C. A., Henry, W. L., Mastrofrancesco, B., Martin, B., & Albina, J. E. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65362-x · Cited by 97 · see citing works
Nitric oxide synthase inhibitors attenuate human monocyte chemotaxis in vitro
Belenky, S. N., Robbins, R., & Rubinstein, I. (1993) · Journal of Leukocyte Biology · doi:10.1002/jlb.53.5.498 · Cited by 94 · see citing works
Enhancement of wound repair with a topically applied nitric oxide‐releasing polymer
Shabani, M., Pulfer, S. K., Bulgrin, J. P., & Smith, D. J. B. (1996) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1996.40312.x · Cited by 93 · see citing works
Role of nitric oxide in wound healing
Efron, D. T., Most, D., & Barbul, A. (2000) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200005000-00006 · Cited by 93 · see citing works
Nitric Oxide Regulates IL-8 Expression in Melanoma Cells at the Transcriptional Level
Andrew, P. J., Harant, H., & Lindley, I. J. D. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2378 · Cited by 92 · see citing works
FRANK, S., Kämpfer, H., Wetzler, C., Stallmeyer, B., & Pfeilschifter, J. M. (2000) · Biochemical Journal · doi:10.1042/bj3470265 · Cited by 85 · see citing works
Arany, I., Brysk, M. M., Brysk, H., & Tyring, S. K. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0452 · Cited by 82 · see citing works
Nitric Oxide Regulation of IL-8 Expression in Human Endothelial Cells
Villarete, L. H., & Remick, D. G. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1864 · Cited by 81 · see citing works
Wound healing in the transforming growth factor‐β1—deficient mouse
Brown, R. L., Ormsby, I., Doetschman, T., & Greenhalgh, D. G. (1995) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1995.30108.x · Cited by 80 · see citing works
Nitric oxide production is intensely and persistently increased in tissue by thermal injury
Carter, E. A., deRojas-Walker, T., Tamir, S., Tannenbaum, S. R., Yu, Y., & Tompkins, R. G. (1994) · Biochemical Journal · doi:10.1042/bj3040201 · Cited by 79 · see citing works
Schäffer, M. R., Tantry, U. S., Gm, A., Wasserkrug, H. L., & Barbul, A. (1997) · PubMed · Cited by 75 · see citing works
Yoram Vodovotz, B., & Bogdan, C. (1994) · Progress in Growth Factor Research · doi:10.1016/0955-2235(94)00004-5 · Cited by 74 · see citing works
Self-citationNitric oxide inhibits wound collagen synthesis
Shukla, A., Rasik, A. M., & Shankar, R. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006977513146 · Cited by 70 · see citing works
The Spatial and Temporal Quantification of Myofibroblasts
McGrath, M. H., & Hundahl, S. A. (1982) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-198206000-00012 · Cited by 70 · see citing works
Eigler, A., Sinha, B. N. M., & Endres, S. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2277 · Cited by 69 · see citing works
Interleukin-8 inhibits the induction of nitric oxide synthase in rat peritoneal neutrophils
McCall, T., Palmer, R. M. J., & Moncada, S. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90800-z · Cited by 66 · see citing works
Konstantinova, N. V., Duong, D.-M. T., Remenyik, É., Hazarika, P., Chuang, A. Z., & Duvic, M. A. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12584215 · Cited by 62 · see citing works
Wang, R., Ghahary, A., Shen, Y. J., Scott, P. G., & Tredget, E. E. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12289708 · Cited by 57 · see citing works
Gamma-irradiation potentiates L-arginine-dependent nitric oxide formation in mice
Voevodskaya, N. V., & Vanin, A. F. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81565-7 · Cited by 57 · see citing works
Nitric Oxide Regulates Interleukin 1 Bioactivity Released from Murine Macrophages
Hill, J. R., Corbett, J. A., Kwon, G., Marshall, C. A., & McDaniel, M. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22672 · Cited by 55 · see citing works
Excessive scarring as a consequence of healing
Ladin, D. A., Garner, W. L., & Smith, D. J. (1995) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1995.30106.x · Cited by 53 · see citing works
Wetzler, C., Kämpfer, H., Pfeilschifter, J. M., & Frank, S. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3170 · Cited by 53 · see citing works
Masihi, K. N. (1994) · M. Dekker eBooks · Cited by 52 · see citing works
Parnham, M. J. (1995) · Inflammation Research · doi:10.1007/bf01782972 · Cited by 50 · see citing works
Willis, R. A., Nussler, A. K., Fries, K. M., Geller, D. A., & Phipps, R. P. (1994) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1994.1077 · Cited by 46 · see citing works
Chu, A. J., & Prasad, J. K. (1999) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(98)00303-2 · Cited by 45 · see citing works
Kp, X., Huang, S., DONG, Z., & FIDLER, I. (1993) · International Journal of Oncology · doi:10.3892/ijo.3.6.1043 · Cited by 43 · see citing works
Nitric Oxide Production by Human Peripheral Blood Polymorphonuclear Leucocytes
Goode, H. F., Webster, N. R., Howdle, P. D., & WALKER, B. E. (1994) · Clinical Science · doi:10.1042/cs0860411 · Cited by 43 · see citing works
Expression and function of inducible nitric oxide synthase during rat colon anastomotic healing
Efron, D. T., Thornton, F. J., Steulten, C., Tantry, U. S., Witte, M. B., Kiyama, T., & Barbul, A. (1999) · Journal of Gastrointestinal Surgery · doi:10.1016/s1091-255x(99)80080-8 · Cited by 41 · see citing works
Induction of nitric oxide synthase in rat intestine and its association with tissue injury
Boughton-Smith, N. K., Evans, S., Whittle, B. J. R., & Moncada, S. (1993) · Inflammation Research · doi:10.1007/bf01991159 · Cited by 40 · see citing works
Nickoloff, B. J., & Mitra, R. S. (1989) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12284427 · Cited by 36 · see citing works
Chemotaxis of freshly separated and cultured human keratinocytes
Gyulai, R., Hunyadi, J., Kenderessy, A. S., Kemény, L. V., & DOBOZY, A. (1994) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.1994.tb01201.x · Cited by 36 · see citing works
Endogenous nitric oxide production by human monocytic cells regulates LPS-induced TNF production.
Zinetti, M., Fantuzzi, G., Delgado, R., Santo, E. D., Ghezzi, P., & Fratelli, M. (1995) · PubMed · Cited by 36 · see citing works
Sepsis Impairs Anastomotic Collagen Gene Expression and Synthesis: A Possible Role for Nitric Oxide
Thornton, F. J., Ahrendt, G. M., Schäffer, M. R., Tantry, U. S., & Barbul, A. (1997) · Journal of Surgical Research · doi:10.1006/jsre.1997.5034 · Cited by 35 · see citing works
Schmid, P., Cox, D., McMaster, G. K., & Itin, P. H. (1993) · Archives of Dermatological Research · doi:10.1007/bf00371833 · Cited by 31 · see citing works
Nitric oxide inhibition of transforming growth factor-beta and collagen synthesis in mesangial cells
Craven, P. A., Studer, R. K., Felder, J., Phillips, S. L., & DeRubertis, F. R. (1997) · Diabetes · doi:10.2337/diabetes.46.4.671 · Cited by 31 · see citing works
Effect of Nitric Oxide Synthase Inhibitor on Experimentally Induced Burn Wounds
Akçay, M. N., zcan, N., Gündoğdu, C., ay, G. N. R. A., Balk, A., se, K. K., & ren, D. (2000) · doi:10.1097/00005373-200008000-00022 · Cited by 29 · see citing works
Evidence for a NO synthase in porcine platelets which is stimulated during activation/aggregation
Berkels, R., BERTSCH, A., Zuther, T., Dhein, S., Stockklauser, K., Rosen, P., & Rösen, R. (1997) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1997.tb01676.x · Cited by 28 · see citing works
Increased expression of inducihie nitric oxide (NO) synthase
Weller, R., & Ormerod, A. D. (1997) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1997.tb08768.x · Cited by 27 · see citing works
Self-citationArbos, M. A., J.M, Ferrando, Vidal, J., Quiles, M., Huguet, P., Castells, J., Segarra, A., Armengol, M., & Schwartz, S. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00836-5 · Cited by 26 · see citing works
A comparison of the stimulatory effects of cytokines on normal and psoriatic keratinocytes in vitro
Olaniran, A. K., Baker, B. S., Garioch, J., Powles, A. V., & Fry, L. (1995) · Archives of Dermatological Research · doi:10.1007/bf01105071 · Cited by 24 · see citing works
Remote Tissue Injury Primes Hepatocytes for Nitric Oxide Synthesis
Freeswick, P. D., Wan, Y., Geller, D. A., Nussler, A. K., & Billiar, T. R. (1994) · Journal of Surgical Research · doi:10.1006/jsre.1994.1132 · Cited by 24 · see citing works
Self-citation(2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8241-5 · Cited by 22 · see citing works
Arginine-free diet suppresses nitric oxide production in wounds
Bulgrin, J. P., Shabani, M., & Smith, D. J. (1993) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(93)90027-t · Cited by 21 · see citing works
Vasoactive intestinal peptide and nitric oxide in the acute phase following burns and trauma
Onuoha, G. N., Alpar, K., & Jones, I. (2001) · Burns · doi:10.1016/s0305-4179(00)00073-5 · Cited by 20 · see citing works
Kang‐Rotondo, C. H., Major, S., Chiang, T. M., Myers, L. K., & Kang, E. S. (1996) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.1996.tb00176.x · Cited by 20 · see citing works
Regulation of the Expression of the Inducible Isoform of Nitric Oxide Synthase by Glucocorticoidsa
Szabó, C. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09007.x · Cited by 19 · see citing works
Brown, Z., Robson, R. L., & Westwick, J. K. (1993) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2952-1_8 · Cited by 17 · see citing works
THE INFLUENCE OF WOUND HEALING OF URINARY NITRATE LEVELS IN RATS
Smith, D. J. B., & Dunphy, M. (1991) · Cited by 13 · see citing works
Vallette, G., Jarry, A., Branka, J., & LABOISSE, C. L. (1996) · Biochemical Journal · doi:10.1042/bj3130035 · Cited by 12 · see citing works
Yoram Vodovotz, B., & Barccellos-Hoff, M. H. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8241-5_3 · Cited by 5 · see citing works
Self-citationDOWNREGULATION OF INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION IN KELOIDS
Lim, T., Moochhala, S., Waller, T. L. T., Chhatwal, V. J. S., Suhumaran, S., Hon, W., & Khoo, H. E. (1996) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199610000-00052 · Cited by 4 · see citing works
Bauer, J. A., Harr, M. E., & Smith, D. J. B. (1999) · Nitric Oxide · doi:10.1006/niox.1999.0252 · Cited by 4 · see citing works
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Franz, S., Rammelt, S., Scharnweber, D., & Simon, J. C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.078 · Cited by 1,391 · see citing works
Therapeutic strategies for enhancing angiogenesis in wound healing
Veith, A. P., Henderson, K., Spencer, A., Sligar, A. D., & Baker, A. B. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.09.010 · Cited by 1,030 · see citing works
Nitric oxide and redox mechanisms in the immune response
Wink, D. A., Hines, H. B., Cheng, R. Y. S., Switzer, C. H., Flores-Santana, W., Vitek, M. P., Ridnour, L. A., & Colton, C. A. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1010550 · Cited by 765 · see citing works
Biomaterials: Foreign Bodies or Tuners for the Immune Response?
Mariani, E., Lisignoli, G., Borzì, R. M., & Pulsatelli, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030636 · Cited by 706 · see citing works
Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications
Hamdan, S., Pastar, I., Drakulich, S., Dikici, E., Tomic‐Canic, M., Deo, S. K., & Daunert, S. (2017) · ACS Central Science · doi:10.1021/acscentsci.6b00371 · Cited by 526 · see citing works
Nitric Oxide Therapy for Diabetic Wound Healing
Malone‐Povolny, M. J., Maloney, S. E., & Schoenfisch, M. H. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801210 · Cited by 509 · see citing works
The Role of Chemokines in Wound Healing
Ridiandries, A., Tan, J. T. M., & Bursill, C. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103217 · Cited by 479 · see citing works
Nitric oxide: a newly discovered function on wound healing
Luo, J., & Chen, A. F. (2005) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2005.00058.x · Cited by 410 · see citing works
Role of nitric oxide, nitroxidative and oxidative stress in wound healing.
Soneja, A., Drews, M., & Maliñski, T. (2005) · PubMed · Cited by 349 · see citing works
Biocompatible Materials for Continuous Glucose Monitoring Devices
Nichols, S. P., Koh, A., Storm, W. L., Shin, J. H., & Schoenfisch, M. H. (2013) · Chemical Reviews · doi:10.1021/cr300387j · Cited by 347 · see citing works
Molecular Mechanisms That Link Oxidative Stress, Inflammation, and Fibrosis in the Liver
Ramos‐Tovar, E., & Muriel, P. (2020) · Antioxidants · doi:10.3390/antiox9121279 · Cited by 348 · see citing works
Nitric oxide function in the skin
Cals-Grierson, M. M., & Ormerod, A. D. (2004) · Nitric Oxide · doi:10.1016/j.niox.2004.04.005 · Cited by 328 · see citing works
Factors That Impair Wound Healing
Anderson, K., & Hamm, R. L. (2012) · Journal of the American College of Clinical Wound Specialists · doi:10.1016/j.jccw.2014.03.001 · Cited by 327 · see citing works
A Review on Free Radicals and Antioxidants
Alkadi, H. (2018) · Infectious Disorders - Drug Targets · doi:10.2174/1871526518666180628124323 · Cited by 318 · see citing works
The Toxicity of Silica Nanoparticles to the Immune System
Chen, L., Liu, J., Zhang, Y., Zhang, G., Kang, Y., Chen, A., Feng, X., & Shao, L. (2018) · Nanomedicine · doi:10.2217/nnm-2018-0076 · Cited by 322 · see citing works
Honey for Wound Healing, Ulcers, and Burns; Data Supporting Its Use in Clinical Practice
Al-Waili, N., Salom, K., & Al-Ghamdi, A. (2011) · The Scientific World JOURNAL · doi:10.1100/tsw.2011.78 · Cited by 316 · see citing works
Analytical Chemistry of Nitric Oxide
Hetrick, E. M., & Schoenfisch, M. H. (2009) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-060908-155146 · Cited by 316 · see citing works
Arginine Supplementation and Wound Healing
Stechmiller, J. K., Childress, B. B., & Cowan, L. J. (2005) · Nutrition in Clinical Practice · doi:10.1177/011542650502000152 · Cited by 260 · see citing works
Low-Energy Laser Irradiation Promotes Cellular Redox Activity
Lubart, R., Eichler, M., Lavi, R., Friedman, H., & Shainberg, A. (2005) · Photomedicine and Laser Surgery · doi:10.1089/pho.2005.23.3 · Cited by 248 · see citing works
The biphasic nature of nitric oxide responses in tumor biology
Ridnour, L. A., Thomas, D. D., Donzelli, S., Espey, M. G., Roberts, D. D., Wink, D. A., & Isenberg, J. S. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.1329 · Cited by 247 · see citing works
Managing Diabetic Foot Ulcers: Pharmacotherapy for Wound Healing
Dixon, D. J., & EDMONDS, M. E. (2020) · Drugs · doi:10.1007/s40265-020-01415-8 · Cited by 228 · see citing works
Honey and Microbial Infections: A Review Supporting the Use of Honey for Microbial Control
Al-Waili, N. S. D., Salom, K., Butler, G. J., & Ghamdi, A. A. A. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.0161 · Cited by 227 · see citing works
Dinitrosyl iron complexes with thiolate ligands: physico-chemistry, biochemistry and physiology
Vanin, A. F. (2009) · Nitric Oxide · doi:10.1016/j.niox.2009.03.005 · Cited by 217 · see citing works
Komatsu, D. E., & Hadjiargyrou, M. (2004) · Bone · doi:10.1016/j.bone.2003.12.024 · Cited by 212 · see citing works
Molecular mechanisms for discrete nitric oxide levels in cancer
Ridnour, L. A., Thomas, D. D., Switzer, C., Flores‐Santana, W., Isenberg, J. S., Ambs, S., Roberts, D. D., & Wink, D. A. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.04.006 · Cited by 196 · see citing works
Polymer‐Based Nitric Oxide Therapies: Recent Insights for Biomedical Applications
Jen, M. C., Serrano, M. C., van Lith, R., & Ameer, G. A. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201101707 · Cited by 194 · see citing works
Geisel, R. E., Sakamoto, K., Russell, D. G., & Rhoades, E. R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.5007 · Cited by 190 · see citing works
A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective
Trinh, T. X., Long, N. V., Anh, L. T. V., Nga, P. T., Giang, N. N., Chien, P. N., Nam, S., & Heo, C. Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179573 · Cited by 193 · see citing works
Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing
Kaur, G., Narayanan, G., Garg, D., Sachdev, A., & Matai, I. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00035 · Cited by 185 · see citing works
Cho, C., Sung, H., Kim, K.-T., Cheon, H. G., Oh, G. T., Hong, H. J., Yoo, O., & Koh, G. Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506352103 · Cited by 173 · see citing works
Mi, Q., Rivière, B. M., Clermont, G., Steed, D. L., & Yoram Vodovotz, B. (2007) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00271.x · Cited by 166 · see citing works
Shahid, M. M., Rameshkumar, P., Pandikumar, A., Lim, . N., Ng, Y. H., & Huang, N. M. (2015) · Journal of Materials Chemistry A · doi:10.1039/c5ta02608c · Cited by 164 · see citing works
Reduced foreign body response at nitric oxide-releasing subcutaneous implants
Hetrick, E. M., Prichard, H. L., Klitzman, B., & Schoenfisch, M. H. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.06.036 · Cited by 158 · see citing works
Non-cytotoxic, in situ gelable hydrogels composed of N-carboxyethyl chitosan and oxidized dextran
Weng, L., Romanov, A. B., Rooney, J., & Chen, W. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.06.025 · Cited by 155 · see citing works
Signaling and stress: The redox landscape in NOS2 biology
Thomas, D. D., Heinecke, J. L., Ridnour, L. A., Cheng, R. Y., Kesarwala, A. H., Switzer, C. H., McVicar, D. W., Roberts, D. D., Glynn, S., Fukuto, J. M., et al. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.002 · Cited by 150 · see citing works
Anti-inflammation biomaterial platforms for chronic wound healing
Xu, Z., Liang, B., Tian, J., & Wu, J. (2021) · Biomaterials Science · doi:10.1039/d1bm00637a · Cited by 151 · see citing works
Zhou, X., Wang, H., Zhang, J., Li, X., Wu, Y., Wei, Y.-Z., Ji, S.-L., Kong, D.-L., & Zhao, Q. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.03.011 · Cited by 130 · see citing works
Ponrasu, T., Kannan, R., Ramachandran, B., Ganeshkumar, M., Suguna, L., & Muthuvijayan, V. (2018) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2018.01.110 · Cited by 147 · see citing works
A physiologically active polysaccharide hydrogel promotes wound healing
Luo, Y., Diao, H., Xia, S., Dong, L., Chen, J., & Zhang, J. (2010) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32711 · Cited by 132 · see citing works
Nanomaterials for application in wound Healing: current state-of-the-art and future perspectives
Shalaby, M. A., Anwar, M. M., & Saeed, H. M. S. (2022) · Journal of Polymer Research · doi:10.1007/s10965-021-02870-x · Cited by 129 · see citing works
Honey: A Potential Therapeutic Agent for Managing Diabetic Wounds
Alam, F., Islam, M. A., Gan, S. H., & Khalil, M. I. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/169130 · Cited by 124 · see citing works
Anti-aging effects of l-arginine
Gad, M. Z. (2010) · Journal of Advanced Research · doi:10.1016/j.jare.2010.05.001 · Cited by 121 · see citing works
Isenberg, J. S., Ridnour, L. A., Espey, M. G., Wink, D. A., & Roberts, D. A. (2005) · Microsurgery · doi:10.1002/micr.20168 · Cited by 121 · see citing works
Champeau, M., Póvoa, V., Militão, L., Cabrini, F. M., Picheth, G. F., Meneau, F., Jara, C. P., ARAUJO, E. P. D., & de Oliveira, M. G. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.05.025 · Cited by 118 · see citing works
Al-Waili, N., & Haq, A. (2004) · Journal of Medicinal Food · doi:10.1089/jmf.2004.7.491 · Cited by 115 · see citing works
Whey protein enhances normal inflammatory responses during cutaneous wound healing in diabetic rats
Ebaid, H., Salem, A., Sayed, A. A., & Metwalli, A. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-235 · Cited by 115 · see citing works
Park, J., Choi, S.-H., Park, S.-J., Lee, Y. J., Park, J. S., Song, P. H., Cho, C.-M., Ku, S., & Song, C. (2017) · Marine Drugs · doi:10.3390/md15040112 · Cited by 114 · see citing works
Bağdaş, D., Etöz, B. Ç., Gül, Z., Ziyanok, S., İnan, S., Turacozen, O., Gül, N. Y., Topal, A., Çinkılıç, N., Taş, S., et al. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.04.001 · Cited by 113 · see citing works
Opioids heal ischemic wounds in the rat
Poonawala, T., Levay‐Young, B. K., Hebbel, R. P., & Gupta, K. (2005) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2005.130207.x · Cited by 112 · see citing works
González, C., Corbacho, A. M., Eiserich, J. P., García, C., López-Barrera, F., Morales‐Tlalpan, V., Barajas‐Espinosa, A. R., Díaz‐Muñoz, M., Rubio, R., Lin, S.-H., et al. (2004) · Endocrinology · doi:10.1210/en.2004-0647 · Cited by 112 · see citing works
Mechanisms of action for light therapy: A review of molecular interactions
Prindeze, N. J., Moffatt, L. T., & Shupp, J. W. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.012180 · Cited by 111 · see citing works
Sindelar, J. J., & Milkowski, A. L. (2011) · Cited by 111 · see citing works
Nitric Oxide Is a Key Component in Inflammation-Accelerated Tumorigenesis
Hussain, S. P., He, P., Subleski, J. J., Hofseth, L. J., Trivers, G. E., Mechanic, L. E., Hofseth, A. B., Bernard, M., Schwank, J., Nguyen, G. H., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0410 · Cited by 108 · see citing works
S‐nitrosoglutathione‐containing hydrogel accelerates rat cutaneous wound repair
Amadeu, T. P., Seabra, A. B., Oliveira, M. D., & Monte‐Alto‐Costa, A. (2007) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2006.02032.x · Cited by 105 · see citing works
Diao, H., Li, X., Chen, J., Luo, Y., Chen, X., Dong, L., Wang, C., Zhang, C., & Zhang, J. (2008) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.105.85 · Cited by 101 · see citing works
Supplemental L‐arginine enhances wound healing in diabetic rats
Shi, H., Most, D., Efron, D. T., Witte, M. B., & Barbul, A. (2003) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2003.11308.x · Cited by 100 · see citing works
Oxidative and Nitrosative Stress and Fibrogenic Response
Urtasun, R., de la Rosa, L. C., & Nieto, N. (2008) · Clinics in Liver Disease · doi:10.1016/j.cld.2008.07.005 · Cited by 99 · see citing works
Nitric oxide enhances collagen synthesis in cultured human tendon cells
Xia, W., Szomor, Z. L., Wang, Y., & Murrell, G. A. C. (2005) · Journal of Orthopaedic Research® · doi:10.1002/jor.20060 · Cited by 97 · see citing works
Transcriptome analysis of the salivary glands of Dermacentor andersoni Stiles (Acari: Ixodidae)
Alarcón-Chaidez, F. J., Sun, J., & Wikel, S. K. (2006) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2006.10.002 · Cited by 98 · see citing works
Nitric Oxide Donor Improves Healing if Applied on Inflammatory and Proliferative Phase
Amadeu, T. P., Seabra, A. B., de Oliveira, M. G., & Monte‐Alto‐Costa, A. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2007.10.015 · Cited by 96 · see citing works
Environmental and Societal Impact of Nanotechnology
Babatunde, D. E., Denwigwe, I. H., Babatunde, O. M., Gbadamosi, S. L., Babalola, I. P., & Agboola, O. (2019) · IEEE Access · doi:10.1109/access.2019.2961513 · Cited by 95 · see citing works
The Effects of Systemic Hypoxia on Colon Anastomotic Healing: An Animal Model
Attard, J.-A. P., Raval, M. J., Martin, G. R., Kolb, J. C., Afrouzian, M., Buie, D. W., & Sigalet, D. L. (2005) · Diseases of the Colon & Rectum · doi:10.1007/s10350-005-0047-3 · Cited by 94 · see citing works
Eisenbud, D. E. (2012) · Clinics in Plastic Surgery · doi:10.1016/j.cps.2012.05.001 · Cited by 93 · see citing works
Influences of opioids and nanoparticles on in vitro wound healing models
Wolf, N. B., Hedtrich, S., Radowski, M. R., Blaschke, T., Kramer, K. D., Weindl, G., Kleuser, B., Haag, R., & Schäfer‐Korting, M. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2009.03.009 · Cited by 93 · see citing works
Electrospun nitric oxide releasing bandage with enhanced wound healing.
Lowe, A., Bills, J. D., Verma, R., Lavery, L., Davis, K., & Balkus, K. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.11.032 · Cited by 86 · see citing works
The link between advanced glycation end products and apoptosis in delayed wound healing
Shaikh‐Kader, A., Houreld, N. N., Rajendran, N. K., & Abrahamse, H. (2019) · Cell Biochemistry and Function · doi:10.1002/cbf.3424 · Cited by 91 · see citing works
Cellular, Biochemical, and Clinical Aspects of Wound Healing
Hackam, D. J., & Ford, H. R. (2002) · Surgical Infections · doi:10.1089/sur.2002.3.s1-23 · Cited by 90 · see citing works
Haque, S. T., Saha, S. K., Haque, M. E., & Biswas, N. (2021) · Biomaterials Science · doi:10.1039/d1bm01211h · Cited by 87 · see citing works
Ebaid, H., Ahmed, O. M., Mahmoud, A. M., & Ahmed, R. R. (2013) · BMC Immunology · doi:10.1186/1471-2172-14-31 · Cited by 88 · see citing works
In Vivo Chemical Sensors: Role of Biocompatibility on Performance and Utility
Soto, R. J., Hall, J. R., Brown, M. D., Taylor, J. B., & Schoenfisch, M. H. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b04251 · Cited by 85 · see citing works
Amri, B., Martino, E., Vitulo, F., Corana, F., Kâab, L. B. B., Rui, M., Rossi, D., Mori, M., Rossi, S., & Collina, S. (2017) · Molecules · doi:10.3390/molecules22111851 · Cited by 86 · see citing works
Nitric Oxide Accelerates the Recovery from Burn Wounds
Zhu, H., Bian, K., & Murad, F. (2007) · World Journal of Surgery · doi:10.1007/s00268-007-0727-3 · Cited by 85 · see citing works
Tang, W., Xie, J., Xu, S., Lv, H., Lin, M., Yuan, S., Bai, J., Hou, Q., & Yu, S. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm5007534 · Cited by 85 · see citing works
Topical S-nitrosoglutathione-releasing hydrogel improves healing of rat ischaemic wounds
Georgii, J. L., Amadeu, T. P., Seabra, A. B., de Oliveira, M. G., & Monte‐Alto‐Costa, A. (2010) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.353 · Cited by 83 · see citing works
Transition‐Metal Nitrosyls for Photocontrolled Nitric Oxide Delivery
Xiang, H., Guo, M., & Liu, J. (2016) · European Journal of Inorganic Chemistry · doi:10.1002/ejic.201601135 · Cited by 83 · see citing works
Pereira, L. D. P., Mota, M. R. L., Brizeno, L. A. C., Nogueira, F. C., Ferreira, E. G. M., Pereira, M. G., & Assreuy, A. M. S. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.04.043 · Cited by 82 · see citing works
S-nitrosated keratin composite mats with NO release capacity for wound healing
Wan, X., Liu, S., Xin, X., Li, P., Dou, J., Han, X., Kang, I., Yuan, J., Chi, B., & Shen, J. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.125964 · Cited by 82 · see citing works
Matrix metalloproteinase 13 mediates nitric oxide activation of endothelial cell migration
López-Rivera, E., Lizarbe, T. R., Martínez‐Moreno, M., López-Novoa, J. M., Rodríguez‐Barbero, A., Rodrigo, J., Fernández, A. P., Alvarez, A. M., Lamas, S., & Zaragoza, C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408217102 · Cited by 82 · see citing works
Nie, X., Zhang, H., Shi, X., Zhao, J., Chen, Y., Wu, F., Yang, J., & Li, X. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106109 · Cited by 81 · see citing works
Fitzsimmons, R. J., Gordon, S. L., Kronberg, J., Ganey, T. M., & Pilla, A. A. (2008) · Journal of Orthopaedic Research® · doi:10.1002/jor.20590 · Cited by 81 · see citing works
Ramadass, S. K., Nazir, L. S., Thangam, R., Kannan, P. R., Manjubala, I., Madhan, B., & Shanmuganathan, S. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.12.025 · Cited by 80 · see citing works
Immunotoxicity of zinc oxide nanoparticles with different size and electrostatic charge
An, S. S. A., Kim, C.-S., Nguyen, H.-D., Ignacio, R. M. C., Kim, J.-H., Cho, H.-C., Meang, E.-H., Kim, Y., Kim, M.-K., Park, B.-K., et al. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s57935 · Cited by 80 · see citing works
Wound healing of different molecular weight of hyaluronan; in-vivo study
Fouda, M. M. G., Abdel-Mohsen, A. M., Ebaid, H., Hassan, I., Al‐Tamimi, J., Abdel-Rahman, R. M., Metwalli, A., Alhazza, I. M., Rady, A. M., El‐Faham, A., et al. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.05.021 · Cited by 79 · see citing works
Houreld, N. N., Sekhejane, P. R., & Abrahamse, H. (2010) · Lasers in Surgery and Medicine · doi:10.1002/lsm.20812 · Cited by 79 · see citing works
S‐Nitrosothiols as Platforms for Topical Nitric Oxide Delivery
de Oliveira, M. G. (2016) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12588 · Cited by 77 · see citing works
Bapat, R. A., Parolia, A., Chaubal, T. V., Dharamadhikari, S., Abdulla, A. M., Sakkir, N., Arora, S., Bapat, P. R., Sindi, A. M., & Kesharwani, P. (2021) · Biomaterials Science · doi:10.1039/d1bm00233c · Cited by 76 · see citing works
Materials Strategies to Overcome the Foreign Body Response
Zhou, X., Wang, Y., Ji, J., & Zhang, P. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304478 · Cited by 77 · see citing works
Immunotoxicity of silicon dioxide nanoparticles with different sizes and electrostatic charge
Kim, S.-K., Kim, J.-H., Kim, C.-S., Ignacio, R. M. C., Kim, D.-H., Sajo, M. E. J., Meang, E.-H., Qi, X., Park, S., Kim, Y., et al. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s57934 · Cited by 76 · see citing works
Biological fate and clinical implications of arginine metabolism in tissue healing
Curran, J. N., Winter, D. C., & Bouchier-Hayes, D. (2006) · Wound Repair and Regeneration · doi:10.1111/j.1743-6109.2006.00151.x · Cited by 76 · see citing works
Piaggesi, A., Läuchli, S., Bassetto, F., Biedermann, T., Marques, A. P., Najafi, B., Palla, I., Scarpa, C., Seimetz, D., Triulzi, I., et al. (2018) · Journal of Wound Care · doi:10.12968/jowc.2018.27.sup6a.s1 · Cited by 75 · see citing works
Ebaid, H., Abdel-Salam, B. K. A., Hassan, I., Al‐Tamimi, J., Metwalli, A., & Alhazza, I. M. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0136-9 · Cited by 74 · see citing works
The Role of Dimethylarginine Dimethylaminohydrolase in Idiopathic Pulmonary Fibrosis
Pullamsetti, S. S., Savai, R., Dumitrascu, R., Dahal, B. K., Wilhelm, J., Königshoff, M., Zakrzewicz, D., Ghofrani, H. A., Weißmann, N., Eickelberg, O., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001725 · Cited by 74 · see citing works
Al-Waili, N. S. D. (2003) · Journal of Medicinal Food · doi:10.1089/109662003772519921 · Cited by 73 · see citing works
Liu, J.-R., Xu, G., Shi, X., & Zhang, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-12043-w · Cited by 72 · see citing works
MacLauchlan, S., Yu, J., Parrish, M. C., Asoulin, T. A., Schleicher, M., Krady, M. M., Zeng, J., Huang, P. L., Sessa, W. C., & Kyriakides, T. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104357108 · Cited by 70 · see citing works
Jones, M. L., Ganopolsky, J. G., Labbé, A., Gilardino, M. S., Wahl, C., Martoni, C., & Prakash, S. (2012) · International Wound Journal · doi:10.1111/j.1742-481x.2011.00889.x · Cited by 68 · see citing works
Cystathionine γ-lyase regulates arteriogenesis through NO-dependent monocyte recruitment
Kolluru, G. K., Bir, S. C., Yuan, S. S., Shen, X., Pardue, S., Wang, R., & Kevil, C. G. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv198 · Cited by 65 · see citing works
Propranolol improves cutaneous wound healing in streptozotocin-induced diabetic rats
Romana‐Souza, B., do Nascimento, A. P., & Monte‐Alto‐Costa, A. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.03.053 · Cited by 68 · see citing works
The effect of nitric oxide surface flux on the foreign body response to subcutaneous implants
Nichols, S. P., Koh, A., Brown, N. L., Rose, M. B., Sun, B., Slomberg, D. L., Riccio, D. A., Klitzman, B., & Schoenfisch, M. H. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.05.053 · Cited by 67 · see citing works
Soto, R. J., Yang, L., & Schoenfisch, M. H. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b10942 · Cited by 67 · see citing works
- Authors
- Schwentker, A., Vodovotz, Y., Weller, R., & Billiar, T. R.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Billiar, Timothy R
- Venue
- Nitric Oxide
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 7
- Issue
- 1
- Pages
- 1-10
- ISSN
- 1089-8603 (ISSN-L)
- OpenAlex
- W1970996854
- Cited by
- 386
- References
- 161
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 15 · 2023: 13 · 2022: 21 · 2021: 20 · 2020: 22 · 2019: 22 · 2018: 20 · 2017: 16 · 2016: 19 · 2015: 11 · 2014: 20 · 2013: 22 · 2012: 18
- FWCI
- 11.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nitric Oxide (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- wound healing, cytokines, nitric oxide synthase, endothelial nitric oxide synthase, inducible nitric oxide synthase, inflammation, angiogenesis, cell proliferation, platelets, fibroblasts, epithelial cells
- MeSH terms
- Animals, Extracellular Matrix, Humans, Inflammation, Nitric Oxide, Wound Healing, Keratinocytes, Cytokines, Neovascularization, Physiologic
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