Cited by 386Wound Healing and TreatmentsNitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Nitric oxide and wound repair: role of cytokines?

Schwentker, Ann, Vodovotz, Yoram, Weller, Richard, Billiar, Timothy R·2002·Nitric Oxide

Abstract

Wound healing involves platelets, inflammatory cells, fibroblasts, and epithelial cells. All of these cell types are capable of producing nitric oxide (NO), either constitutively or in response to inflammatory cytokines, through the activity of nitric oxide synthases (NOSs): eNOS (NOS3; endothelial NOS) and iNOS (NOS2; inducible NOS), respectively. Indeed, pharmacological inhibition or gene deletion of these enzymes impairs wound healing. The wound healing mechanisms that are triggered by NO appear to be diverse, involving inflammation, angiogenesis, and cell proliferation. All of these processes are controlled by defined cytokine cascades; in many cases, NO appears to modulate these cytokines. In this review, we summarize the history and present state of research on the role of NO in wound healing within the framework of modulation of cytokines.

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Crossref · 10.1016/s1089-8603(02)00002-2

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158 of 158 references verified0 citation errors · 0 not checkable

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  • Nitric oxide is believed to control inflammatory cell recruitment in the early stages of the foreign body response.

    “NO is also believed to control inflammatory cell recruitment in the early stages of the FBR.215”

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Authors
Schwentker, A., Vodovotz, Y., Weller, R., & Billiar, T. R.
Affiliations
University of Pittsburgh (US)
Corresponding author
Billiar, Timothy R
Venue
Nitric Oxide
Publisher
Elsevier BV
Published
2002-08
Volume
7
Issue
1
Pages
1-10
ISSN
1089-8603 (ISSN-L)
OpenAlex
W1970996854
Cited by
386
References
161
Citations by year
2026: 5 · 2025: 11 · 2024: 15 · 2023: 13 · 2022: 21 · 2021: 20 · 2020: 22 · 2019: 22 · 2018: 20 · 2017: 16 · 2016: 19 · 2015: 11 · 2014: 20 · 2013: 22 · 2012: 18
FWCI
11.55
Type
journal article
Language
en
Open access
closed
Locations
  • Nitric Oxide (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
wound healing, cytokines, nitric oxide synthase, endothelial nitric oxide synthase, inducible nitric oxide synthase, inflammation, angiogenesis, cell proliferation, platelets, fibroblasts, epithelial cells
MeSH terms
Animals, Extracellular Matrix, Humans, Inflammation, Nitric Oxide, Wound Healing, Keratinocytes, Cytokines, Neovascularization, Physiologic

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