Thrombopoietin, the c-mpl ligand, is a major regulator of platelet production
Abstract
Hematopoiesis is regulated by a family of glycoproteins, the hematopoietic growth factors. Although the cytokines that influence the late stages of granulopoiesis (granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor) or erythropoiesis (erythropoietin) have been identified, characterized, and cloned, and have been in clinical use since that late 1980's, the cytokine that stimulates thrombopoiesis had remained elusive. By using strategies based on the c-mpl receptor, several groups have recently succeeded in purifying and cloning thrombopoietin [1-6]. This study outlines the cloning and biological characterization in vitro and in vivo of thrombopoietin, a major regulator of platelet production.
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Thrombopoietin activates the JAK/STAT3 pathway in megakaryocytes, leading to upregulated expression of multiple genes required for platelet production.
“Thrombopoietin activates the JAK/STAT3 pathway in megakaryocytes”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Broudy and Kaushansky, 1995
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Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works
“Thrombopoietin activates the JAK/STAT3 pathway in megakaryocytes (Broudy and Kaushansky, 1995; Kaushansky, 1995; Drachman and Kaushansky, 1997; Drachman et al., 1997), leading to upregulated expres-”
Background
- Authors
- Broudy, V. C., & Kaushansky, K.
- Affiliations
- University of Washington (US)
- Corresponding author
- Broudy, Virginia C
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-05-01
- Volume
- 57
- Issue
- 5
- Pages
- 719-725
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2418373846
- Cited by
- 39
- References
- 0
- Citations by year
- 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Leukocyte Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- thrombopoietin, c-Mpl receptor, megakaryopoiesis, hematopoietic growth factors, hematopoietic regulation
- MeSH terms
- Amino Acid Sequence, Blood Platelets, Cloning, Molecular, Erythropoietin, Genes, Hematopoiesis, Humans, Ligands, Molecular Sequence Data, Platelet Count, Receptors, Immunologic, Thrombopoietin, Signal Transduction, DNA, Complementary
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