MR imaging of diffuse adenomyosis changes after GnRH analog therapy
Open accessAbstract
Purpose: To evaluate uterine changes on MRI before and after GnRH analog (GnRHa) treatment in diffuse adenomyosis. Materials and Methods: Thirty‐one patients with MRI features suggestive of diffuse adenomyosis received GnRHa for 6 months. Diffuse adenomyosis was sub‐classified as: symmetric (symmetric/ entire widening of the junctional zone [JZ]) and asymmetric (asymmetric/ partial widening of JZ). Pre‐ and post‐high signal intensity (SI) foci and JZ width, and post‐demarcated change (interface of adenomyosis with the myometrium became more discrete with a concomitant decrease in JZ width) were analyzed. Results: Before therapy, 15 of 18 asymmetric contained high SI foci compared to none of symmetric. After therapy, JZ width decreased (P < 0.0001). Eight asymmetric and none of symmetric showed demarcated change with resolved high SI foci. Conclusion: Our results suggest the use of GnRHa is associated with a decrease of JZ width in adenomyosis. Asymmetric adenomyosis with high SI foci appears to be the most sensitive to hormonal therapy. J. Magn. Reson. Imaging 2002;15:285–290. © 2002 Wiley‐Liss, Inc.
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Absence of hyperintense lesions might be caused by hormonal treatment.
“Absence of these hyperintense lesions might be caused by hormonal treatment [23].”
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“Absence of these hyperintense lesions might be caused by hormonal treatment [23].”
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- Authors
- Imaoka, I., Ascher, S. M., Sugimura, K., Takahashi, K., Li, H., Cuomo, F., Simon, J., & Arnold, L. L.
- Affiliations
- Georgetown University Medical Center (US)
- Kobe University (JP)
- Shimane Medical University (JP)
- Yale University (US)
- George Washington University (US)
- Corresponding author
- Imaoka, Izumi
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 2002-02-28
- Volume
- 15
- Issue
- 3
- Pages
- 285-290
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- OpenAlex
- W2013792071
- Cited by
- 72
- References
- 20
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 1 · 2015: 2 · 2014: 7 · 2012: 1
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Magnetic Resonance Imaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- diffuse adenomyosis, GnRH analog therapy, hormone therapy response, uterine MRI
- MeSH terms
- Adult, Endometriosis, Female, Humans, Gonadotropin-Releasing Hormone, Magnetic Resonance Imaging, Middle Aged, Prospective Studies, Uterus, Treatment Outcome
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