Cited by 187Advanced MRI Techniques and ApplicationsCharacterization and Applications of Magnetic NanoparticlesLanthanide and Transition Metal Complexes

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Contrast-enhanced MR imaging of liver and spleen: first experience in humans with a new superparamagnetic iron oxide

Hamm, Bernd, Staks, Thomas, Taupitz, Matthias, Maibauer, Renate, Speidel, Andrea, Huppertz, Alexander, Frenzel, Thomas, Lawaczeck, Rüdiger, Wolf, Karl J., Lange, Lothar·1994·Journal of Magnetic Resonance Imaging

DOI 10.1002/jmri.1880040508

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Abstract

The aim of this prospective study was to obtain the first human safety and magnetic resonance (MR) imaging results with a new formulation of superparamagnetic iron oxide (SPIO) (SHU 555 A). The SPIO was tested at four iron doses, from 5 to 40 mumol/kg. Laboratory tests and clinical measurements were done in 32 healthy volunteers for up to 3 weeks after administration. MR imaging at 1.5 T was performed before and 8 hours to 14 days after fast intravenous injection (500 mumol Fe/min) of the SPIO (six subjects per dose). Results of this phase I study demonstrate that SHU 555 A at a concentration of 0.5 mol Fe/L was well tolerated. A dose-dependent minor increase in activated partial thromboplastin time, which remained within the normal range, was seen. All doses of SPIO caused a signal loss in both liver and spleen (P < .05) with a spin-echo sequence (TR = 2,300 msec, TE = 45 msec). The signal losses in the liver 8 hours after contrast agent injection were 58%, 79%, 82%, and 87% for the 5, 10, 20, and 40 mumol Fe/kg doses, respectively. The corresponding signal losses in the spleen were 23%, 45%, 65%, and 78%, respectively. The doses that reduced signal intensity by half were 3.1 mumol Fe/kg for the liver and 12.8 mumol Fe/kg for the spleen. The results suggest that the new SPIO formulation is a safe and efficient MR contrast agent.

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Authors: Hamm, B., Staks, T., Taupitz, M., Maibauer, R., Speidel, A., Huppertz, A., Frenzel, T., Lawaczeck, R., Wolf, K. J., & Lange, L.
Affiliations: Humboldt-Universität zu Berlin (DE)
Freie Universität Berlin (DE)
Corresponding author: Hamm, Bernd
ORCID: Hamm, Bernd
Taupitz, Matthias
Huppertz, Alexander
Lawaczeck, Rüdiger
Venue: Journal of Magnetic Resonance Imaging
Publisher: Wiley
Published: 1994-09
Volume: 4
Issue: 5
Pages: 659-668
ISSN: 1053-1807 (ISSN-L)
1522-2586
DOI: 10.1002/jmri.1880040508
OpenAlex: W2163391474
Cited by: 187
References: 25
Citations by year: 2024: 5 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 10 · 2013: 15 · 2012: 5
FWCI: 8.80
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4100 d)
Locations: Journal of Magnetic Resonance Imaging (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
Keywords: superparamagnetic iron oxide nanoparticles, MRI contrast agents, liver imaging, spleen imaging, contrast-enhanced MRI, safety and tolerability, activated partial thromboplastin time
MeSH terms: Adult, Contrast Media, Dextrans, Dose-Response Relationship, Drug, Drug Tolerance, Humans, Image Enhancement, Injections, Intravenous, Iron, Liver, Magnetic Resonance Imaging, Male, Oxides, Partial Thromboplastin Time, Placebos, Prospective Studies, Spleen, Suspensions, Single-Blind Method, Ferrosoferric Oxide, Magnetite Nanoparticles

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Contrast-enhanced MR imaging of liver and spleen: first experience in humans with a new superparamagnetic iron oxide

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