Diffusion‐weighted echo‐planar MR imaging and ADC mapping in the differential diagnosis of ovarian cystic masses: Usefulness of detecting keratinoid substances in mature cystic teratomas
Open accessAbstract
Purpose: To elucidate whether apparent diffusion coefficient (ADC) values calculated from echo‐planar diffusion‐weighted MR imaging (EPDWI) are useful in the differential diagnosis of ovarian cystic masses. Materials and Methods: EPDWI was performed in 131 patients with ovarian cystic masses (54 mature cystic teratomas, 35 endometrial cysts, four other benign cysts, 14 benign neoplasms, and 24 malignant neoplasms). The areas of the highest signal intensity on EPDWI (b = 1000 seconds/mm 2) and the lowest ADC values within the cystic component were evaluated. Results: On qualitative and quantitative analyses, mature cystic teratomas tended to show higher signal intensity and had areas of lower ADC values than endometrial cysts and other benign and malignant neoplasms (P < .005). In vitro scanning of the cystic contents of mature cystic teratomas confirmed that high signal on DWI or low ADC value was attributable to the keratinoid substance within the tumors. The difference in ADC between malignant and benign lesions were significant when mature cystic teratomas and endometrial cysts were included, but was not significant when they were excluded. Conclusion: The ADC value may add useful information to the differential diagnosis of ovarian cystic masses in limited populations, such as those with mature cystic teratomas with a small amount of fat. J. Magn. Reson. Imaging 2005;22:271–278. © 2005 Wiley‐Liss, Inc.
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Regarding endometrial cysts, previous studies found a tendency towards lower ADC values compared with other pelvic cysts, which might be more closely related to blood concentration.
“Regarding endometrial cysts, previous studies found a tendency towards lower apparent diffusion coefficient (ADC) values compared with other pelvic cysts, which might be more closely related to blood concentration [19–21].”
From Appearance of abdominal wall endometriosis on MR imaging (2010) · cites this paper as [21]
This is comparable with previous reports on ADC values in endometrial cysts.
“This is comparable with previous reports on ADC values in endometrial cysts [19, 21].”
From Appearance of abdominal wall endometriosis on MR imaging (2010) · cites this paper as [21]
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“This is comparable with previous reports on ADC values in endometrial cysts [19, 21].”
Result
- Authors
- Nakayama, T., Yoshimitsu, K., Irie, H., Aibe, H., Tajima, T., Nishie, A., Asayama, Y., Matake, K., Kakihara, D., Matsuura, S., Nakano, H., & Honda, H.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Yoshimitsu, Kengo
- ORCID
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 2005-07-18
- Volume
- 22
- Issue
- 2
- Pages
- 271-278
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- OpenAlex
- W2061059585
- Cited by
- 168
- References
- 23
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 11 · 2017: 7 · 2016: 5 · 2015: 11 · 2014: 5 · 2013: 14 · 2012: 12
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Magnetic Resonance Imaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
- Health Sciences › Medicine › Surgery › Teratomas and Epidermoid Cysts
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Keywords
- diffusion-weighted imaging, apparent diffusion coefficient, ovarian cystic mass, dermoid cyst, endometrioma, differential diagnosis, ovarian neoplasms
- MeSH terms
- Adult, Aged, Diagnosis, Differential, Female, Humans, Middle Aged, Ovarian Cysts, Ovarian Neoplasms, Probability, Retrospective Studies, Sensitivity and Specificity, Teratoma, Cohort Studies, Echo-Planar Imaging, Diffusion Magnetic Resonance Imaging
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