Vascular volume and blood‐brain barrier permeability measured by dynamic contrast enhanced MRI in hippocampus and cerebellum of patients with MCI and normal controls
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Purpose: To measure the cerebrovascular volume and blood‐brain barrier (BBB) permeability indices in hippocampus and cerebellum of patients with mild cognitive impairment (MCI) using dynamic contrast‐enhanced MRI (DCE‐MRI), and compare to that of normal controls. Materials and Methods: A total of 11 MCI subjects and 11 healthy elderly controls participated in this prospective study. DCE‐MRI was performed to measure the contrast enhancement kinetics. The early enhancement percentage (at 50 seconds after injection) was defined as the vascular volume index, and the ratio between the four to five–minute enhancement relative to the 50‐second enhancement was defined as the BBB permeability index. Results: The enhancement kinetics measured from hippocampus of MCI individuals demonstrated a lower magnitude and slower decay than healthy controls, suggesting that they had a smaller vascular volume (significant in the right side; P <0.001) and a higher BBB permeability (not reaching significance level). The vascular volume index was significantly correlated with naming ability (P 0.05). Conclusion: These results suggest that changes in cerebrovasculature may occur in hippocampus of MCI. DCE‐MRI may provide a noninvasive means to measure the subtle BBB leakage associated with the cerebrovascular pathology commonly found in Alzheimer's disease. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.
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Earlier studies using longer resolution time and semiquantitative analysis indicated a possible trend of increased BBB permeability in the hippocampus in MCI compared with controls.
“Earlier studies using longer resolution time and semiquantitative analysis indicated a possible trend of increased BBB permeability in the hippocampus in MCI compared with controls (631), and suggested that accumulation of contrast agent in brains of individuals with probable AD likely occurs via blood-to-brain-to-CSF pathway (556), consistent with increased blood vessel permeability.”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [631]
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“The lower vascular volume in the hippocampus of MCI subjects was also consistent with results reported in literature measuring cerebral blood flow using single photon emission computed tomography (SPECT) imaging (21,22).”
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- Authors
- Wang, H., Golob, E. J., & Su, M.
- Affiliations
- Peking University (CN)
- Tulane University (US)
- University of California, Irvine (US)
- Corresponding author
- Su, Min‐Ying
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 2006-07-28
- Volume
- 24
- Issue
- 3
- Pages
- 695-700
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- OpenAlex
- W2094234889
- Cited by
- 106
- References
- 1
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 6 · 2023: 3 · 2022: 11 · 2021: 14 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 6 · 2016: 9 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Magnetic Resonance Imaging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (RR00827, AG16573)
- University of California, Irvine (M01RR-00827, P50 AG16573)
- National Institute on Aging (R01AG017066, R01AG019681, AG17066, AG 16573, AG-019681, P50AG016573)
- National Center for Research Resources (RR00827, M01RR000827)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- mild cognitive impairment, blood-brain barrier permeability, hippocampus, cerebellum, dynamic contrast-enhanced MRI, contrast enhancement kinetics, Alzheimer's disease, naming ability, cerebrovascular pathology
- MeSH terms
- Aged, Alzheimer Disease, Blood-Brain Barrier, Brain, Cerebellum, Cognition, Contrast Media, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Kinetics, Magnetic Resonance Imaging, Male, Permeability, Case-Control Studies
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