Resovist enhanced MR imaging of the liver: does quantitative assessment help in focal lesion classification and characterization?
Open accessAbstract
PURPOSE: To improve characterization of focal liver lesions by a prospective quantitative analysis of percentage signal intensity change, in dynamic and late phases after slow (0.5 mL/s) Resovist administration. MATERIALS AND METHODS: Seventy-three patients were submitted on clinical indication to MR examination with Resovist. Signal intensity of 92 detected focal lesions (5-80 mm) were measured with regions of interest and normalized to paravertebral muscle in arterial, portal, equilibrium and T1/T2 late phases, by two observers in conference. Five values of percentage variations per patient were obtained and statistically evaluated. RESULTS: The enhancement obtained on dynamic study is more suitable in hemangiomas and focal nodular hyperplasias than in adenomas and hepatocellular carcinomas. To discriminate benign versus malignant lesions on late-phase-T2-weighted images, a cutoff = -26%, allowed sensitivity and specificity values of 97.4% and 97.7%, respectively. Area under the receiver operating characteristic (ROC) curve was 0.99. To differentiate hemangioma versus all other focal liver lesions, on late-phase-T1-weighted images, a cutoff = +40% permitted sensitivity and specificity values of 90.5% and 98.0%, respectively. Area under the ROC curve was 0.98. CONCLUSION: Late phase quantitative evaluation after slow Resovist administration, allows to differentiate malignant from benign hepatic masses and hemangiomas from all the others focal liver lesions, on T2-/T1-weighted acquisitions, respectively. J
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SPION-enhanced MRI is useful to discriminate between malignant neoplastic liver lesions, benign neoplastic liver lesions or hyperplastic liver lesions.
“SPION-enhanced MRI is useful to discriminate between malignant neoplastic liver lesions (e.g. HCC or metastasis), benign neoplastic liver lesions (e.g. adenoma or hemangioma) or hyperplastic liver lesions (e.g. focal nodular hyperplasia) [149].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [149]
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
- Authors
- Santoro, L., Grazioli, L., Filippone, A., Grassedonio, E., Belli, G., & Colagrande, S.
- Affiliations
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- University of Chieti-Pescara (IT)
- Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo (IT)
- Corresponding author
- Colagrande, Stefano
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 2009-10-23
- Volume
- 30
- Issue
- 5
- Pages
- 1012-1020
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- OpenAlex
- W1990916204
- Cited by
- 18
- References
- 24
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2012: 2
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Journal of Magnetic Resonance Imaging (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- Resovist, focal liver lesions, liver lesion characterization, hepatocellular carcinoma, hepatocellular adenoma, focal nodular hyperplasia, hepatic hemangioma, contrast-enhanced MRI
- MeSH terms
- Adult, Aged, Aged, 80 and over, Contrast Media, Dextrans, Female, Ferric Compounds, Humans, Image Processing, Computer-Assisted, Liver, Magnetic Resonance Imaging, Male, Middle Aged, ROC Curve, Reproducibility of Results, Ferrosoferric Oxide, Magnetite Nanoparticles
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