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Cited by 151Bone health and osteoporosis researchAdvanced MRI Techniques and ApplicationsBone and Joint Diseases

MRI assessment of bone structure and microarchitecture

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Chang, Gregory, Boone, Sean, Martel, Dimitri, Rajapakse, Chamith S., Hallyburton, Robert S., Valko, Mitch, Honig, Stephen, Regatte, Ravinder R.·2017·Journal of Magnetic Resonance Imaging
DOI 10.1002/jmri.25647PMC PMC5690546
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Abstract

Osteoporosis is a disease of weak bone and increased fracture risk caused by low bone mass and microarchitectural deterioration of bone tissue. The standard‐of‐care test used to diagnose osteoporosis, dual‐energy x‐ray absorptiometry (DXA) estimation of areal bone mineral density (BMD), has limitations as a tool to identify patients at risk for fracture and as a tool to monitor therapy response. Magnetic resonance imaging (MRI) assessment of bone structure and microarchitecture has been proposed as another method to assess bone quality and fracture risk in vivo. MRI is advantageous because it is noninvasive, does not require ionizing radiation, and can evaluate both cortical and trabecular bone. In this review article, we summarize and discuss research progress on MRI of bone structure and microarchitecture over the last decade, focusing on in vivo translational studies. Single‐center, in vivo studies have provided some evidence for the added value of MRI as a biomarker of fracture risk or treatment response. Larger, prospective, multicenter studies are needed in the future to validate the results of these initial translational studies. Level of Evidence: 5 Technical Efficacy: Stage 5 J. MAGN. RESON. IMAGING 2017;46:323–337

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  • MRI is a medical imaging modality that allows for the evaluation of soft-tissue diseases and the assessment of bone quality.

    “Magnetic Resonance Imaging (MRI) is a medical imaging modality that allows for the evaluation of soft-tissue diseases and the assessment of bone quality.”

    From Towards 2D/3D Registration of the Preoperative MRI to Intraoperative Fluoroscopic Images for Visualisation of Bone Defects (2023) · cites this paper as Chang et al. 2017

    The paper’s Abstract (page not provided) describes MRI as a proposed method for assessing bone quality in vivo. The passages address bone structure and physiology, but do not substantiate the separate claim that MRI evaluates soft-tissue diseases (searched: soft-tissue disease and musculoskeletal disease imaging). (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Chang, G., Boone, S., Martel, D., Rajapakse, C. S., Hallyburton, R. S., Valko, M., Honig, S., & Regatte, R. R.
Affiliations
  • NYU Langone Health (US)
  • Hospital of the University of Pennsylvania (US)
Corresponding author
Chang, Gregory
ORCID
Venue
Journal of Magnetic Resonance Imaging
Publisher
Wiley
Published
2017-02-06
Volume
46
Issue
2
Pages
323-337
ISSN
  • 1053-1807 (ISSN-L)
  • 1522-2586
DOI
10.1002/jmri.25647
PMC
PMC5690546
OpenAlex
W2586570460
Cited by
151
References
2
Citations by year
2026: 9 · 2025: 26 · 2024: 16 · 2023: 17 · 2022: 21 · 2021: 21 · 2020: 16 · 2019: 13 · 2018: 9 · 2017: 3
FWCI
2.04
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Magnetic Resonance Imaging (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01‐AR070131 (G.C.), R01‐AR066008 (G.C.), R01‐AR06)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone and Joint Diseases
Keywords
osteoporosis, bone microarchitecture, bone structure, fracture risk, bone quality, trabecular bone, cortical bone, bone mineral density, treatment response monitoring
MeSH terms
Adult, Aged, Aged, 80 and over, Bone and Bones, Female, Humans, Hypogonadism, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Osteoporosis, Risk, Absorptiometry, Photon, Bone Density, Osteoporosis, Postmenopausal, Finite Element Analysis, Diabetes Complications, Fractures, Bone, Translational Research, Biomedical

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