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An introduction to quadrupole–time‐of‐flight mass spectrometry
Abstract
A brief introduction is presented to the basic principles and application of a quadrupole–time‐of‐flight (TOF) tandem mass spectrometer. The main features of reflecting TOF instruments with orthogonal injection of ions are discussed. Their operation and performance are compared with those of triple quadrupoles with electrospray ionization and matrix‐assisted laser desorption/ionization (MALDI) TOF mass spectrometers. Examples and recommendations are provided for all major operational modes: mass spectrometry (MS) and tandem MS (MS/MS), precursor ion scans and studies of non‐covalent complexes. Basic algorithms for liquid chromatography/MS/MS automation are discussed and illustrated by two applications. Copyright © 2001 John Wiley & Sons, Ltd.
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Cited by
Mass Spectrometry, Review of the Basics: Electrospray, MALDI, and Commonly Used Mass Analyzers
El-Aneed, A., Cohen, A., & Banoub, J. (2009) · Applied Spectroscopy Reviews · doi:10.1080/05704920902717872 · Cited by 386
Cappellin, L., Karl, T., Probst, M., Ismailova, O., Winkler, P. M., Soukoulis, C., Aprea, E., Märk, T. D., Gasperi, F., & Biasioli, F. (2012) · Environmental Science & Technology · doi:10.1021/es203985t · Cited by 344
Ekroos, K., Chernushevich, I. V., Simons, K., & Shevchenko, A. (2002) · Analytical Chemistry · doi:10.1021/ac015655c · Cited by 306
Self-citationFrom QCEIMS to QCxMS: A Tool to Routinely Calculate CID Mass Spectra Using Molecular Dynamics
Koopman, J., & Grimme, S. (2021) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.1c00098 · Cited by 80
Metadata
- Authors
- Chernushevich, I. V., Loboda, A. V., & Thomson, B. A.
- Venue
- Journal of Mass Spectrometry
- Publisher
- Wiley
- Published
- 2001-08
- Volume
- 36
- Issue
- 8
- Pages
- 849-865
- ISSN
- 1076-5174 (ISSN-L)
- 1096-9888
- OpenAlex
- W2104372768
- Cited by
- 705
- References
- 0
- FWCI
- 9.94
- Type
- journal article
- Language
- en
- Open access
- closed
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