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Primary respiratory syncytial virus infection in mice
Abstract
A mouse model of respiratory syncytial virus (RSV) infection is described. A high‐titered, large‐volume inoculum results in replication of RSV to a high titer in lungs of BALB/c mice. Mice older than 15 weeks of age are more susceptible to RSV infection. Titers up to 10 6.9 plaque‐forming units (pfu)/gram lung can be attained in 32‐week‐old mice. Older mice experience a clinical illness manifested by ruffled fur, reduced activity, and weight loss. Lung histology of older mice infected with RSV shows bronchiolitis and increased number of lymphocytes and macrophages in alveolar spaces compared with that of mice less than 8 weeks old. This model will serve as the basis for investigating immunodeterminants of recovery and protection from RSV infection.
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Cited by
Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus
McLellan, J. S., Chen, M., Joyce, M. G., Sastry, M., Stewart-Jones, G. B. E., Yang, Y., Zhang, B., Chen, L., Srivatsan, S., Zheng, A., et al. (2013) · Science · doi:10.1126/science.1243283 · Cited by 1,126
Self-citationStructure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody
McLellan, J. S., Chen, M., Leung, S., Graepel, K. W., Du, X., Yang, Y., Zhou, T., Baxa, U., Yasuda, E., Beaumont, T., et al. (2013) · Science · doi:10.1126/science.1234914 · Cited by 883
Self-citationTraggiai, E., Becker, S., Subbarao, K., Kolesnikova, L., Uematsu, Y., Gismondo, M. R., Murphy, B. R., Rappuoli, R., & Lanzavecchia, A. (2004) · Nature Medicine · doi:10.1038/nm1080 · Cited by 697
Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease
Byers, D. E., Alexander-Brett, J., Patel, A. C., Agapov, E., Dang-Vu, G., Jin, X., Wu, K., You, Y., Alevy, Y., Girard, J.-P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65570 · Cited by 337
Haeberle, H. A., Takizawa, R., Casola, A., Brasier, A. R., Dieterich, H., van Rooijen, N., Gatalica, Z., & Garofalo, R. P. (2002) · The Journal of Infectious Diseases · doi:10.1086/344644 · Cited by 237
Antioxidant treatment ameliorates respiratory syncytial virus-induced disease and lung inflammation
Castro, S. M., Guerrero-Plata, A., Suarez-Real, G., Adegboyega, P. A., Colasurdo, G. N., Khan, A. M., Garofalo, R. P., & Casola, A. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200603-319oc · Cited by 160
Respiratory syncytial virus vaccine development
Crowe, J. E. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00287-0 · Cited by 70
Metadata
- Authors
- Graham, B. S., Perkins, M. D., Wright, P. F., & Karzon, D. T.
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 1988-10
- Volume
- 26
- Issue
- 2
- Pages
- 153-162
- ISSN
- 0146-6615 (ISSN-L)
- 1096-9071
- OpenAlex
- W2097984707
- Cited by
- 393
- References
- 0
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
