Impact of human cytomegalovirus (CMV) infection on immune response to pandemic 2009 H1N1 influenza vaccine in healthy adults
Open accessAbstract
Human cytomegalovirus (CMV) infection has been implicated in immunosenescence. To examine the influence of CMV on ability of healthy adults to respond to a novel influenza antigen, the rate of seroconversion and the magnitude of titers to pandemic 2009 H1N1 vaccine was assessed. The clinical trial was stratified by age; 52 persons aged 18–64 and 55 aged 65 and older were enrolled. Among the younger group, 33% had CMV antibody compared with 62% among the older group. No differences by CMV seropositivity in the proportion of participants achieving a seroprotective titer 21 days following the second immunization were noted. However, the geometric mean titer in hemagglutination inhibition assay was significantly higher among CMV seronegative younger participants compared with CMV seropositive younger participants (385 vs. 142, P = 0.013). In contrast, among the older group, CMV serostatus was not associated with differential antibody titers (53 vs. 63, P = 0.75). These data suggest that CMV may shape immune response to neoantigens among younger persons; these groups should be included in future studies of immunosenescence and CMV. J. Med. Virol. 85:1557–1560, 2013. © 2013 Wiley Periodicals, Inc.
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Some studies have shown no effect of CMV on vaccine responses in the elderly.
“For example, some studies have shown no effect of CMV on vaccine responses in the elderly (den Elzen et al. 2011; O’Connor et al. 2014; Wald et al. 2013) and other studies have even reported vaccine-boosting effects of CMV in young individuals (Furman et al. 2015).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Wald et al. 2013
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References 9 · Cited by 50
- Authors
- Wald, A., Selke, S., Magaret, A., & Boeckh, M.
- Affiliations
- University of Washington (US)
- Corresponding author
- Wald, Anna
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 2013-07-12
- Volume
- 85
- Issue
- 9
- Pages
- 1557-1560
- ISSN
- 0146-6615 (ISSN-L)
- 1096-9071
- PMC
- PMC3805380
- OpenAlex
- W1899668122
- Cited by
- 50
- References
- 9
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 10 · 2015: 4 · 2014: 3 · 2013: 1
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Medical Virology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (N01-AI-80004, HHSN272200800004C, R43AI080004)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- human cytomegalovirus infection, immunosenescence, 2009 H1N1 influenza vaccine, vaccine antibody response, seroconversion, hemagglutination inhibition, CMV serostatus, age differences, healthy adults, neoantigens
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Viral, Cytomegalovirus Infections, Double-Blind Method, Female, Hemagglutination Inhibition Tests, Humans, Influenza, Human, Influenza Vaccines, Male, Middle Aged, Influenza A Virus, H1N1 Subtype, Young Adult
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