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A systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus—A possible reference for coronavirus disease‐19 treatment option
Open accessAbstract
In the past few decades, coronaviruses have risen as a global threat to public health. Currently, the outbreak of coronavirus disease‐19 (COVID‐19) from Wuhan caused a worldwide panic. There are no specific antiviral therapies for COVID‐19. However, there are agents that were used during the severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) epidemics. We could learn from SARS and MERS. Lopinavir (LPV) is an effective agent that inhibits the protease activity of coronavirus. In this review, we discuss the literature on the efficacy of LPV in vitro and in vivo, especially in patients with SARS and MERS, so that we might clarify the potential for the use of LPV in patients with COVID‐19.
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Cited by
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Sultan, S., Altayar, O., Siddique, S. M., Davitkov, P., Feuerstein, J. D., Lim, J. K., Falck-Ytter, Y., & El-Serag, H. B. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.05.001 · Cited by 437
Paital, B., Das, K., & Parida, S. K. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138914 · Cited by 281
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Mohd Aman, A. H., Hassan, W. H., Sameen, S., Attarbashi, Z. S., Alizadeh, M., & Latiff, L. A. (2021) · Journal of Network and Computer Applications · doi:10.1016/j.jnca.2020.102886 · Cited by 237
Metadata
- Authors
- Yao, T., Qian, J., Zhu, W., Wang, Y., & Wang, G.
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 2020-03-12
- Volume
- 92
- Issue
- 6
- Pages
- 556-563
- ISSN
- 0146-6615 (ISSN-L)
- 1096-9071
- OpenAlex
- W3008131087
- Cited by
- 469
- References
- 0
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yao, T., Qian, J., Zhu, W., Wang, Y., & Wang, G. (2020). A systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus—A possible reference for coronavirus disease‐19 treatment option. Journal of Medical Virology. https://doi.org/10.1002/jmv.25729
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