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Cited by 986COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchLong-Term Effects of COVID-19

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Clinical Features and Treatment of COVID-19 Patients in Northeast Chongqing

Open access
Wan, Suxin, Xiang, Yi, Fang, Wei, Zheng, Yu, Li, Boqun, Hu, Yanjun, Lang, Chunhui, Huang, Daoqiu, Sun, Qiuyan, Xiong, Yan, Huang, Xia, Lv, Jinglong, Luo, Yaling, Shen, Li, Yang, Haoran, Huang, Gu, Yang, Ruishan·2020·Journal of Medical Virology
DOI 10.1002/jmv.25783PMC PMC7228368
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Abstract

The outbreak of the novel coronavirus in China (SARS-CoV-2) that began in December 2019 presents a significant and urgent threat to global health. This study was conducted to provide the international community with a deeper understanding of this new infectious disease. Epidemiological, clinical features, laboratory findings, radiological characteristics, treatment, and clinical outcomes of 135 patients in northeast Chongqing were collected and analyzed in this study. A total of 135 hospitalized patients with COVID-19 were enrolled. The median age was 47 years (interquartile range, 36-55), and there was no significant gender difference (53.3% men). The majority of patients had contact with people from the Wuhan area. Forty-three (31.9%) patients had underlying disease, primarily hypertension (13 [9.6%]), diabetes (12 [8.9%]), cardiovascular disease (7 [5.2%]), and malignancy (4 [3.0%]). Common symptoms included fever (120 [88.9%]), cough (102 [76.5%]), and fatigue (44 [32.5%]). Chest computed tomography scans showed bilateral patchy shadows or ground glass opacity in the lungs of all the patients. All patients received antiviral therapy (135 [100%]) (Kaletra and interferon were both used), antibacterial therapy (59 [43.7%]), and corticosteroids (36 [26.7%]). In addition, many patients received traditional Chinese medicine (TCM) (124 [91.8%]). It is suggested that patients should receive Kaletra early and should be treated by a combination of Western and Chinese medicines. Compared to the mild cases, the severe ones had lower lymphocyte counts and higher plasma levels of Pt, APTT, d-dimer, lactate dehydrogenase, PCT, ALB, C-reactive protein, and aspartate aminotransferase. This study demonstrates the clinic features and therapies of 135 COVID-19 patients. Kaletra and TCM played an important role in the treatment of the viral pneumonia. Further studies are required to explore the role of Kaletra and TCM in the treatment of COVID-19.

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Crossref · 10.1002/jmv.25783

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Research works printed but not linked: 2

  1. General Office of the National Health and Family PlanningCommission, 2020, Diagnosis and treatment of novel coronavirus pneumonia (trial version 5), Chin J Integr Med, 3
  2. Wang F, 2018, Effects of matrine combied with baicalin on mouse pneumonia induced by LPS, Chin Pharmacol Bull, 8, 1105

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Metadata

Authors
Wan, S., Xiang, Y., Fang, W., Zheng, Y., Li, B., Hu, Y., Lang, C., Huang, D., Sun, Q., Xiong, Y., Huang, X., Lv, J., Luo, Y., Shen, L., Yang, H., Huang, G., & Yang, R.
Affiliations
  • Chongqing University (CN)
  • Chongqing Medical University (CN)
  • Pharmaceutical Department of Chongqing Three Gorges Central Hospital Chongqing University Three Gorges Hospital Chongqing China
Corresponding author
  • Zheng, Yu
  • Li, Boqun
  • Hu, Yanjun
ORCID
Venue
Journal of Medical Virology
Publisher
Wiley
Published
2020-04
Volume
92
Issue
7
Pages
797-806
ISSN
  • 0146-6615 (ISSN-L)
  • 1096-9071
DOI
10.1002/jmv.25783
PMC
PMC7228368
OpenAlex
W3012673820
Cited by
982
References
27
Citations by year
2026: 2 · 2025: 13 · 2024: 40 · 2023: 75 · 2022: 125 · 2021: 299 · 2020: 427
FWCI
30.44
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Medical Virology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fundamental Research Funds for the Central Universities (2020CDJYGRH-YJ03)
  • National Social Science Foundation (15BGL191)
Topics
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
Keywords
COVID-19 pandemic, SARS-CoV-2, clinical features, lopinavir/ritonavir, ritonavir, traditional Chinese medicine, antiviral therapy, corticosteroids, antibiotic therapy, interferon, viral pneumonia, chest CT findings, ground-glass opacities, lymphocyte count, D-dimer, lactate dehydrogenase, C-reactive protein, comorbidities, hospitalized patients
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Testing, Adolescent, Adrenal Cortex Hormones, Adult, Aged, Anti-Bacterial Agents, Antiviral Agents, Cardiovascular Diseases, China, Cough, Diabetes Mellitus, Drug Combinations, Drugs, Chinese Herbal, Fatigue, Female, Fever, Humans, Interferons, Male, Middle Aged, Neoplasms, Pneumonia, Viral, Retrospective Studies, Severity of Illness Index, Tomography, X-Ray Computed, Biomarkers, Coronavirus Infections, Clinical Laboratory Techniques, Ritonavir, Diabetes Complications, Pandemics, Lopinavir

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