The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Stability issues of RT‐PCR testing of SARS‐CoV‐2 for hospitalized patients clinically diagnosed with COVID‐19
Open accessAbstract
In this study, we collected a total of 610 hospitalized patients from Wuhan between February 2, 2020, and February 17, 2020. We reported a potentially high false negative rate of real‐time reverse‐transcriptase polymerase chain reaction (RT‐PCR) testing for SARS‐CoV‐2 in the 610 hospitalized patients clinically diagnosed with COVID‐19 during the 2019 outbreak. We also found that the RT‐PCR results from several tests at different points were variable from the same patients during the course of diagnosis and treatment of these patients. Our results indicate that in addition to the emphasis on RT‐PCR testing, clinical indicators such as computed tomography images should also be used not only for diagnosis and treatment but also for isolation, recovery/discharge, and transferring for hospitalized patients clinically diagnosed with COVID‐19 during the current epidemic. These results suggested the urgent needs for the standard of procedures of sampling from different anatomic sites, sample transportation, optimization of RT‐PCR, serology diagnosis/screening for SARS‐CoV‐2 infection, and distinct diagnosis from other respiratory diseases such as fluenza infections as well.
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Xie, X., Zhong, Z., Zhao, W., Zheng, C., Wang, F., & Liu, J. (2020) · Radiology · doi:10.1148/radiol.2020200343 · Cited by 1,960 · cited 1×
“However, it was reported on February 12, 2020 that five infected patients had initial negative or weakly positive RT‐PCR results.(4) In another reported case, the third time RT‐PCR test result for pharyngeal swab specimen from an”
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Cited by
Rubin, G. D., Ryerson, C. J., Haramati, L. B., Sverzellati, N., Kanne, J. P., Raoof, S., Schluger, N. W., Volpi, A., Yim, J.-J., Martin, I. B. K., et al. (2020) · Radiology · doi:10.1148/radiol.2020201365 · Cited by 1,101
Bai, H. X., Wang, R., Xiong, Z., Hsieh, B., Chang, K., Halsey, K., Tran, T. M. L., Choi, J. W., Wang, D.-C., Shi, L.-B., et al. (2020) · Radiology · doi:10.1148/radiol.2020201491 · Cited by 381
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Metadata
- Authors
- Li, Y., Yao, L., Li, J., Chen, L., Song, Y., Cai, Z., & Yang, C.
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 2020-04-05
- Volume
- 92
- Issue
- 7
- Pages
- 903-908
- ISSN
- 0146-6615 (ISSN-L)
- 1096-9071
- OpenAlex
- W3013640245
- Cited by
- 687
- References
- 1
- FWCI
- 19.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, Y., Yao, L., Li, J., Chen, L., Song, Y., Cai, Z., & Yang, C. (2020). Stability issues of RT‐PCR testing of SARS‐CoV‐2 for hospitalized patients clinically diagnosed with COVID‐19. Journal of Medical Virology. https://doi.org/10.1002/jmv.25786
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
