Three-photon microscopy shows that somatic release can be a quantitatively significant component of serotonergic neurotransmission in the mammalian brain
Abstract
Recent experiments on monoaminergic neurons have shown that neurotransmission can originate from somatic release. However, little is known about the quantity of monoamine available to be released through this extrasynaptic pathway or about the intracellular dynamics that mediate such release. Using three-photon microscopy, we directly imaged serotonin autofluorescence and investigated the total serotonin content, release competence, and release kinetics of somatic serotonergic vesicles in the dorsal raphe neurons of the rat. We found that the somata of primary cultured neurons contain a large number of serotonin-filled vesicles arranged in a perinuclear fashion. A similar distribution is also observed in fresh tissue slice preparations obtained from the rat dorsal raphe. We estimate that the soma of a cultured neuron on an average contains about 9 fmoles of serotonin in about 450 vesicles (or vesicle clusters) of < or =370 nm average diameter. A substantial fraction (>30%) of this serotonin is released with a time scale of several minutes by K(+)-induced depolarization or by para-chloroamphetamine treatment. The amount of releasable serotonin stored in the somatic vesicles is comparable to the total serotonin content of all the synaptic vesicles in a raphe neuron, indicating that somatic release can potentially play a major role in serotonergic neurotransmission in the mammalian brain.
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5-HT can be released somatodendritically and from 5-HT axon terminals in the DRN.
“As 5-HT can be released somatodendritically and from 5-HT axon terminals in the DRN (Colgan et al., 2012; de Kock et al., 2006; Kaushalya et al., 2008), we examined the expression patterns of 5-HT receptors in the dataset to infer local 5-HT signaling.”
From Molecular and anatomical organization of the dorsal raphe nucleus (2019) · cites this paper as Kaushalya et al., 2008
Cites
Localization of mitochondria in living cells with rhodamine 123.
Johnson, L. V., Walsh, M. L., & Chen, L. B. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.2.990 · Cited by 1,548 · see citing works
Optical Analysis of Synaptic Vesicle Recycling at the Frog Neuromuscular Junction
Betz, W. J., & Bewick, G. S. (1992) · Science · doi:10.1126/science.1553547 · Cited by 763 · see citing works
Rothwell, J. C. (1982) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.45.5.476 · Cited by 749 · see citing works
Dendritic release of dopamine in the substantia nigra
Chéramy, A., Leviel, V., & Glowinski, J. (1981) · Nature · doi:10.1038/289537a0 · Cited by 738 · see citing works
Schneggenburger, R., Meyer, A. C., & Neher, E. (1999) · Neuron · doi:10.1016/s0896-6273(00)80789-8 · Cited by 621 · see citing works
Activity-dependent fluorescent staining and destaining of living vertebrate motor nerve terminals
Betz, W. J., Mao, F., & Bewick, G. S. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00363.1992 · Cited by 576 · see citing works
Intercellular communication in the brain: Wiring versus volume transmission
Agnati, L. F., Zoli, M., Strömberg, I., & Fuxé, K. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00308-6 · Cited by 569 · see citing works
Efflux of dopamine from the synaptic cleft in the nucleus accumbens of the rat brain
Garris, P. A., Ciolkowski, E. L., Pastore, P., & Wightman, R. M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-10-06084.1994 · Cited by 475 · see citing works
Measuring Serotonin Distribution in Live Cells with Three-Photon Excitation
Maiti, S., Shear, J. B., Williams, R. M., Zipfel, W. R., & Webb, W. W. (1997) · Science · doi:10.1126/science.275.5299.530 · Cited by 417 · see citing works
Real-time measurement of transmitter release from single synaptic vesicles
Bruns, D., & Jahn, R. (1995) · Nature · doi:10.1038/377062a0 · Cited by 407 · see citing works
Stevens, C. F., & Tsujimoto, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.846 · Cited by 371 · see citing works
Volume transmission in the CNS and its relevance for neuropsychopharmacology
Zoli, M. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01343-7 · Cited by 346 · see citing works
The Biochemical Basis of Neuropharmacology
(1997) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(97)89442-5 · Cited by 328 · see citing works
Bunin, M. A., & Wightman, R. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-13-04854.1998 · Cited by 326 · see citing works
Vishwasrao, H. D., Heikal, A. A., Kasischke, K. A., & Webb, W. W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502475200 · Cited by 297 · see citing works
Ca2+-Dependent Exocytosis in the Somata of Dorsal Root Ganglion Neurons
Huang, L., & Neher, E. (1996) · Neuron · doi:10.1016/s0896-6273(00)80287-1 · Cited by 289 · see citing works
Vesicle pool mobilization during action potential firing at hippocampal synapses
Ryan, T. A., & Smith, S. J. (1995) · Neuron · doi:10.1016/0896-6273(95)90336-4 · Cited by 282 · see citing works
Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei
Adell, A., Celada, P., Abellán, M. T., & Artigas, F. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00182-0 · Cited by 254 · see citing works
Bruns, D., Riedel, D., Klingauf, J., & Jahn, R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00097-0 · Cited by 221 · see citing works
Increased mitochondrial uptake of rhodamine 123 during lymphocyte stimulation.
Darżynkiewicz, Z., Staiano‐Coico, L., & Melamed, M. R. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.4.2383 · Cited by 212 · see citing works
Chemosensitivity of rat medullary raphe neurones in primary tissue culture
Wang, W., Pizzonia, J. H., & Richerson, G. B. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.433bh.x · Cited by 202 · see citing works
Jaffe, E. H., Marty, A., Schulte, A., & Chow, R. H.-P. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03548.1998 · Cited by 200 · see citing works
Bockstaele, E. J. V., & Pickel, V. M. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903340408 · Cited by 196 · see citing works
Paracrine neurotransmission in the CNS: involvement of 5-HT
Bunin, M. A., & Wightman, R. M. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01410-1 · Cited by 187 · see citing works
Serotonin neurons, neuroplasticity, and homeostasis of neural tissue
Azmitia, E. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00022-6 · Cited by 184 · see citing works
White, L., Eaton, M., Mc, C., Klose, K., Globus, M. Y. T., Shaw, G., & Whittemore, S. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-11-06744.1994 · Cited by 168 · see citing works
Evanescent field excitation of fluorescence by epi-illumination microscopy
Stout, A. L., & Axelrod, D. (1989) · Applied Optics · doi:10.1364/ao.28.005237 · Cited by 159 · see citing works
Extrasynaptic Release of Dopamine in a Retinal Neuron
Puopolo, M., Hochstetler, S. E., Gustincich, S., Wightman, R. M., & Raviola, E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00274-4 · Cited by 134 · see citing works
Choline metabolism in the cerebral cortex of guinea pigs. Stable-bound acetylcholine
Barker, L. A., Dowdall, M. J., & Whittaker, V. P. (1972) · Biochemical Journal · doi:10.1042/bj1301063 · Cited by 131 · see citing works
Yazulla, S., Studholme, K. M., McIntosh, H. H., & Deutsch, D. G. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991206)415:1 · Cited by 128 · see citing works
Zoli, M. (1996) · Progress in Neurobiology · doi:10.1016/s0301-0082(96)00020-2 · Cited by 118 · see citing works
Zoli, M., & Agnati, L. F. (1996) · Progress in Neurobiology · doi:10.1016/0301-0082(96)00020-2 · Cited by 110 · see citing works
Crespi, F., Martin, K. F., & Marsden, C. A. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90191-1 · Cited by 106 · see citing works
Using FM1-43 to study neuropeptide granule dynamics and exocytosis
Brumback, A. C. (2004) · Methods · doi:10.1016/j.ymeth.2004.01.002 · Cited by 101 · see citing works
Maurice, T., Roman, F. J., & Privat, A. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19961215)46:6 · Cited by 100 · see citing works
Chen, G., Gavin, P. F., Luo, G., & Ewing, A. G. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07747.1995 · Cited by 92 · see citing works
Serotonin Receptors in Neurobiology
(2007) · CRC Press eBooks · doi:10.1201/9781420005752 · Cited by 85 · see citing works
The role of 5‐hydroxytryptamine as a transmitter between identified leech neurones in culture.
Henderson, L. P. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014718 · Cited by 79 · see citing works
Williams, R. M., Shear, J. B., Zipfel, W. R., Maiti, S., & Webb, W. W. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77343-1 · Cited by 73 · see citing works
Somatic Exocytosis of Serotonin Mediated by L‐Type Calcium Channels in Cultured Leech Neurones
Trueta, C., Méndez, B., & De‐Miguel, F. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.030684 · Cited by 65 · see citing works
De Kock, C. P. J., Cornelisse, L. N., Burnashev, N., Lodder, J. C., Timmerman, A. J., Couey, J. J., Mansvelder, H. D., & Brussaard, A. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.115311 · Cited by 55 · see citing works
Miao, H., Rubakhin, S. S., & Sweedler, J. V. (2003) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-003-2191-8 · Cited by 42 · see citing works
Quantitative measurement of serotonin synthesis and sequestration in individual live neuronal cells
Balaji, J. M., Desai, R., Kaushalya, S. K., Eaton, M. J., & Maiti, S. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03489.x · Cited by 40 · see citing works
Zaidi, Z. F., & Matthews, M. R. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00664-1 · Cited by 34 · see citing works
Nag, S., Balaji, J. M., Madhu, P. K., & Maiti, S. (2008) · Biophysical Journal · doi:10.1529/biophysj.107.121384 · Cited by 21 · see citing works
A high-resolution large area serotonin map of a live rat brain section
Kaushalya, S. K., Nag, S., Ghosh, H., Arumugam, S., & Maiti, S. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3282fd6946 · Cited by 19 · see citing works
Multiphoton-Excited Serotonin Photochemistry
Gostkowski, M. L., Allen, R., Plenert, M. L., Okerberg, E. S., Gordon, M. J., & Shear, J. B. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74370-2 · Cited by 15 · see citing works
Perinuclear localization of biogenic amines (serotonin and histamine) in rat immune cells
CSABA, G., & Kovacs, P. L. (2006) · Cell Biology International · doi:10.1016/j.cellbi.2006.06.021 · Cited by 15 · see citing works
Rajaofetra, N., Kachidian, P., Marlier, L. N. J. L., Poulat, P., König, N., Geffard, M., & Privat, A. (1991) · Brain Research · doi:10.1016/0006-8993(91)91012-p · Cited by 13 · see citing works
NMR studies of 5-hydroxytryptamine transport through large unilamellar vesicle membranes.
Viscio, D. B., & Prestegard, J. H. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.3.1638 · Cited by 8 · see citing works
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De‐Miguel, F. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031495 · Cited by 4 · see citing works
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- Authors
- Kaushalya, S. K., Desai, R., Arumugam, S., Ghosh, H., Balaji, J., & Maiti, S.
- Affiliations
- Tata Institute of Fundamental Research (IN)
- University of California, Los Angeles (US)
- Corresponding author
- Maiti, S.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2008-08-15
- Volume
- 86
- Issue
- 15
- Pages
- 3469-3480
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2088872749
- Cited by
- 50
- References
- 50
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 7 · 2014: 4 · 2013: 3 · 2012: 8
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (05995/Z/99/Z/HH/KO)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- serotonergic neurotransmission, dorsal raphe neurons, monoaminergic neurons, serotonin storage, release kinetics, potassium depolarization, three-photon microscopy
- MeSH terms
- Animals, Brain, Cells, Cultured, Female, Immunohistochemistry, Microscopy, Microscopy, Fluorescence, Synaptic Transmission, Neurons, Organ Culture Techniques, Serotonin, Vacuoles, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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