Minocycline: a neuroprotective agent for hypoxic-ischemic brain injury in the neonate?
Abstract
Minocycline is a second-generation tetracycline and a potential neuroprotective intervention following brain injury. However, despite the recognized beneficial effects of minocycline in a multitude of adult disease states, the clinical application of minocycline in neonates is contentious. Tetracyclines, as a class, are not usually administered to neonates, but there is compelling evidence that minocycline reduces brain injury after neonatal hypoxic-ischemic brain injury. This Review focuses on the evidence for minocycline use in neonates by considering aspects of pharmacology, drug regimens, functional outcomes, and mechanisms of action.
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Minocycline is an established inhibitor of microglial activation.
“minocycline, an established inhibitor of microglial ‘activation’ (Buller et al., 2009)”
From Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner (2012) · cites this paper as Buller et al., 2009
Cites
Wu, D. C., Jackson-Lewis, V., Vila, M., Tieu, K., Teismann, P., Vadseth, C., Choi, D.-K., Ischiropoulos, H., & Przedborski, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01763.2002 · Cited by 1,183 · see citing works
Back, S. A., Gan, X., Li, Y., Rosenberg, P. A., & Volpe, J. J. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06241.1998 · Cited by 586 · see citing works
Tomás-Camardiel, M., Rite, I., Herrera, A. J., de Pablos, R. M., Cano, J., Machado, A., & Venero, J. L. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.01.010 · Cited by 203 · see citing works
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Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · see citing works
“In addition to genetic manipulation of CR3, microglia involvement in eye-specific segregation was further validated by manipulating microglia function pharmacologically using minocycline, an established inhibitor of microglial ‘‘activation’’ (Buller et al., 2009; Figures S6A–S6E).”
Microglia Function in Central Nervous System Development and Plasticity
Schafer, D. P., & Stevens, B. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020545 · Cited by 353 · see citing works
- Authors
- Buller, K. M., Carty, M. L., Reinebrant, H. E., & Wixey, J. A.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Buller, Kathryn M.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2008-10
- Volume
- 87
- Issue
- 3
- Pages
- 599-608
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W1978528200
- Cited by
- 73
- References
- 3
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 7 · 2016: 4 · 2015: 7 · 2014: 6 · 2013: 4 · 2012: 9
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Keywords
- minocycline, neuroprotection, hypoxic-ischemic brain injury, neonates, tetracycline, drug safety in neonates, drug regimens, functional outcome, mechanism of action
- MeSH terms
- Animals, Animals, Newborn, Anti-Inflammatory Agents, Antioxidants, Blood-Brain Barrier, Brain, Humans, Infant, Newborn, Minocycline, Necrosis, Neurons, Apoptosis, Neuroprotective Agents, Infant Behavior, Hypoxia-Ischemia, Brain, Matrix Metalloproteinase Inhibitors
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