The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Volume regulation in astrocytes: A role for taurine as an osmoeffector
Abstract
Astrocytes in culture regulate their volume under anisosmotic conditions by as yet unclear mechanisms. In a number of other cells this process involves a loss of intracellular osmotically active solutes, including taurine. The possibility that taurine participates as an osmoeffector in astrocytes was examined in cultured astrocytes exposed to hyposmolar conditions. Astrocytes responded to decreases in osmolarity by rapid swelling followed by a volume regulatory phase. Hyposmotic conditions induced a dramatic increase of 3 H‐taurine efflux, with a time course corresponding to the cell volume regulatory phase. Decreasing osmolarity from 310 to 254, 198 or 150 m osmoles resulted in the release of 8.2%, 17%, and 54%, respectively, of 3 H‐taurine previously accumulated by astrocytes. Endogenous taurine concentration decreased 64%. The efflux of 3‐H GABA, 3 H‐glycine, or 3 H‐D‐aspartate was much less affected under similar conditions. These results suggest a role for taurine as an osmoeffector in astrocytes.
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Cites
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Cited by
Diffusion in Brain Extracellular Space
Syková, E., & Nicholson, C. (2008) · Physiological Reviews · doi:10.1152/physrev.00027.2007 · Cited by 1,481
Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures
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The Diversity of Volume Regulatory Mechanisms
Lang, F., Busch, G. L., & Völkl, H. (1998) · Cellular Physiology and Biochemistry · doi:10.1159/000016269 · Cited by 310
Astroglial Excitability and Gliotransmission: An Appraisal of Ca 2+ as a Signalling Route
Zorec, R., Araque, A., Carmignoto, G., Haydon, P. G., Verkhratsky, A., & Parpura, V. (2012) · ASN Neuro · doi:10.1042/an20110061 · Cited by 264
Metadata
- Authors
- Morales, H. P., & Schousboe, A.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 1988-08
- Volume
- 20
- Issue
- 4
- Pages
- 505-509
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2062238583
- Cited by
- 261
- References
- 19
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
